RBP Type	Canonical_RBPs
Diseases	Cancer Disease
Drug	N.A.
Main interacting RNAs	tRNA
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000065427	Gene ID	3735	Accession	6215
Symbol	KARS1	Alias	KRS;KARS;KARS2;LEPID;CMTRIB;DEAPLE;DFNB89	Full Name	lysyl-tRNA synthetase 1
Status	Confidence	Length	20192 bases	Strand	Minus strand
Position	16 : 75627474 - 75647665	RNA binding domain	tRNA_anti-codon , tRNA-synt_2
Summary	Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]