RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	TF
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000064835	Gene ID	5449	Accession	9210
Symbol	POU1F1	Alias	PIT1;CPHD1;GHF-1;Pit-1;POU1F1a	Full Name	POU class 1 homeobox 1
Status	Confidence	Length	17181 bases	Strand	Minus strand
Position	3 : 87259404 - 87276584	RNA binding domain	N.A.
Summary	This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
POU1F1-201	ENST00000344265	1566	317aa	ENSP00000342931
POU1F1-202	ENST00000350375	1488	291aa	ENSP00000263781
POU1F1-204	ENST00000561167	650	216aa	ENSP00000454072
POU1F1-203	ENST00000560656	647	169aa	ENSP00000452610

Gene Model

Click here to download ENSG00000064835's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
28387	Nutritional and Metabolic Diseases	1.4120000E-005	-
28388	Nutritional and Metabolic Diseases	8.3360000E-006	-
28395	Nutritional and Metabolic Diseases	8.6820000E-006	-
28405	Nutritional and Metabolic Diseases	7.4920000E-006	-
28411	Nutritional and Metabolic Diseases	8.6820000E-006	-
28412	Nutritional and Metabolic Diseases	6.1960000E-005	-
28426	Nutritional and Metabolic Diseases	1.0620000E-005	-
28439	Nutritional and Metabolic Diseases	2.9980000E-005	-
28440	Nutritional and Metabolic Diseases	7.1220000E-006	-
28450	Nutritional and Metabolic Diseases	3.2430000E-005	-
28593	Fibrinogen	4.7420000E-005	-
29192	Cholesterol, HDL	3.3960000E-005	-
29225	Cholesterol, HDL	8.9580000E-005	-
29273	Cholesterol, HDL	3.4830000E-005	-
29274	Cholesterol, HDL	9.2170000E-005	-
52263	Child Development Disorders, Pervasive	4.0000000E-005	-
61067	Tourette Syndrome	4E-7	25158072
61068	Obsessive-Compulsive Disorder	4E-7	25158072

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000064835's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	1	IEA	Homo_sapiens(9606)	Process
GO:0000785	part_of chromatin	1	ISA	Homo_sapiens(9606)	Component
GO:0000978	enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	1	IBA	Homo_sapiens(9606)	Function
GO:0000981	enables DNA-binding transcription factor activity, RNA polymerase II-specific	3	IBA,IDA,ISA	Homo_sapiens(9606)	Function
GO:0001228	enables DNA-binding transcription activator activity, RNA polymerase II-specific	1	IEA	Homo_sapiens(9606)	Function
GO:0003700	enables DNA-binding transcription factor activity	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0006355	involved_in regulation of DNA-templated transcription	1	IDA	Homo_sapiens(9606)	Process
GO:0006357	involved_in regulation of transcription by RNA polymerase II	1	IBA	Homo_sapiens(9606)	Process
GO:0008285	involved_in negative regulation of cell population proliferation	1	TAS	Homo_sapiens(9606)	Process
GO:0021984	involved_in adenohypophysis development	1	IEA	Homo_sapiens(9606)	Process
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process
GO:0061629	enables RNA polymerase II-specific DNA-binding transcription factor binding	1	IPI	Homo_sapiens(9606)	Function
GO:0106222	enables lncRNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:1990837	enables sequence-specific double-stranded DNA binding	1	IDA	Homo_sapiens(9606)	Function

Expression