RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	SARS-COV-2
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000063854	Gene ID	3029	Accession	4805
Symbol	HAGH	Alias	GLO2;GLX2;GLXII;HAGH1	Full Name	hydroxyacylglutathione hydrolase
Status	Confidence	Length	31538 bases	Strand	Minus strand
Position	16 : 1795620 - 1827157	RNA binding domain	Lactamase_B
Summary	The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000455422	Lactamase_B	PF00753	3.7e-11	1
ENSP00000380511	Lactamase_B	PF00753	4.9e-11	1
ENSP00000380514	Lactamase_B	PF00753	1.1e-10	1
ENSP00000455355	Lactamase_B	PF00753	3.8e-10	1
ENSP00000455970	Lactamase_B	PF00753	1.5e-09	1
ENSP00000406552	Lactamase_B	PF00753	3.5e-07	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
HAGH-204	ENST00000564445	864	239aa	ENSP00000455355
HAGH-207	ENST00000566644	612	64aa	ENSP00000457986
HAGH-202	ENST00000397356	2619	308aa	ENSP00000380514
HAGH-203	ENST00000455446	1276	236aa	ENSP00000406552
HAGH-201	ENST00000397353	1257	260aa	ENSP00000380511
HAGH-210	ENST00000567398	1473	No protein	-
HAGH-208	ENST00000566709	1291	258aa	ENSP00000455422
HAGH-211	ENST00000569339	820	160aa	ENSP00000455970
HAGH-212	ENST00000569700	1156	No protein	-
HAGH-209	ENST00000567190	472	No protein	-
HAGH-205	ENST00000564518	513	No protein	-
HAGH-206	ENST00000565097	1147	No protein	-

Gene Model

Click here to download ENSG00000063854's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000063854's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004416	enables hydroxyacylglutathione hydrolase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005739	is_active_in mitochondrion	1	IBA	Homo_sapiens(9606)	Component
GO:0005759	located_in mitochondrial matrix	1	IEA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006749	involved_in glutathione metabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0006750	involved_in glutathione biosynthetic process	1	IDA	Homo_sapiens(9606)	Process
GO:0019243	involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	1	IEA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function

Expression