RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	TF
Localizations	Stress granule or P-body
BulkPerturb-seq

Ensembl ID	ENSG00000062194	Gene ID	65056	Accession	29520
Symbol	GPBP1	Alias	GPBP;SSH6;VASCULIN	Full Name	GC-rich promoter binding protein 1
Status	Confidence	Length	90732 bases	Strand	Plus strand
Position	5 : 57173948 - 57264679	RNA binding domain	N.A.
Summary	This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
GPBP1-203	ENST00000424459	4683	493aa	ENSP00000401596
GPBP1-208	ENST00000514387	3310	302aa	ENSP00000421709
GPBP1-204	ENST00000506184	4506	473aa	ENSP00000421202
GPBP1-205	ENST00000511209	2243	465aa	ENSP00000422337
GPBP1-201	ENST00000264779	1786	480aa	ENSP00000264779
GPBP1-207	ENST00000513732	463	No protein	-
GPBP1-206	ENST00000513524	529	No protein	-
GPBP1-202	ENST00000309096	1385	No protein	-
GPBP1-209	ENST00000515484	962	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
100546	Alzheimer Disease	9E-6	26993346
100547	Neurodegenerative Diseases	9E-6	26993346
106930	Schizophrenia	4E-6	23212062

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003677	enables DNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0003700	enables DNA-binding transcription factor activity	1	IEA	Homo_sapiens(9606)	Function
GO:0003723	enables RNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0005886	located_in plasma membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0006351	involved_in DNA-templated transcription	1	IEA	Homo_sapiens(9606)	Process
GO:0006355	involved_in regulation of DNA-templated transcription	1	IBA	Homo_sapiens(9606)	Process
GO:0043231	located_in intracellular membrane-bounded organelle	1	IDA	Homo_sapiens(9606)	Component
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	1	IEA	Homo_sapiens(9606)	Process