RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	Nucleoli
BulkPerturb-seq

Ensembl ID	ENSG00000055130	Gene ID	8454	Accession	2551
Symbol	CUL1	Alias	NA	Full Name	cullin 1
Status	Confidence	Length	103197 bases	Strand	Plus strand
Position	7 : 148697914 - 148801110	RNA binding domain	N.A.
Summary	Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in plasma membrane. Part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
CUL1-202	ENST00000409469	2857	776aa	ENSP00000387160
CUL1-210	ENST00000662716	3086	776aa	ENSP00000499277
CUL1-214	ENST00000665936	2938	776aa	ENSP00000499255
CUL1-212	ENST00000663044	3054	776aa	ENSP00000499398
CUL1-203	ENST00000602748	3054	776aa	ENSP00000473318
CUL1-213	ENST00000663835	3038	732aa	ENSP00000499525
CUL1-204	ENST00000655324	2887	720aa	ENSP00000499675
CUL1-208	ENST00000662132	3080	759aa	ENSP00000499276
CUL1-217	ENST00000671421	3247	51aa	ENSP00000499303
CUL1-215	ENST00000666124	2918	732aa	ENSP00000499244
CUL1-205	ENST00000656001	3040	649aa	ENSP00000499287
CUL1-201	ENST00000325222	3147	776aa	ENSP00000326804
CUL1-216	ENST00000671397	2888	214aa	ENSP00000499516
CUL1-209	ENST00000662670	3056	109aa	ENSP00000499321
CUL1-207	ENST00000660240	2650	678aa	ENSP00000499358
CUL1-211	ENST00000662975	1062	No protein	-
CUL1-206	ENST00000660013	843	281aa	ENSP00000499325

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
39309	Platelet Function Tests	1.2048700E-005	-
62864	Inflammatory Bowel Diseases	3E-10	28067908
104984	Crohn Disease	6E-7	28067908

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000082	involved_in G1/S transition of mitotic cell cycle	1	TAS	Homo_sapiens(9606)	Process
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IC	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	1	IC	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0005886	located_in plasma membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0006513	involved_in protein monoubiquitination	1	IEA	Homo_sapiens(9606)	Process
GO:0008283	involved_in cell population proliferation	1	IEA	Homo_sapiens(9606)	Process
GO:0009887	involved_in animal organ morphogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0016567	involved_in protein ubiquitination	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0019005	part_of SCF ubiquitin ligase complex	3	IBA,IDA,ISS	Homo_sapiens(9606)	Component
GO:0030674	enables protein-macromolecule adaptor activity	1	IBA	Homo_sapiens(9606)	Function
GO:0031146	involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	3	IBA,IDA,ISS	Homo_sapiens(9606)	Process
GO:0031461	part_of cullin-RING ubiquitin ligase complex	1	IDA	Homo_sapiens(9606)	Component
GO:0031625	enables ubiquitin protein ligase binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0043161	involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0070936	involved_in protein K48-linked ubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:0097193	involved_in intrinsic apoptotic signaling pathway	1	TAS	Homo_sapiens(9606)	Process
GO:0160072	enables ubiquitin ligase complex scaffold activity	1	IDA	Homo_sapiens(9606)	Function
GO:1990452	part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex	1	IPI	Homo_sapiens(9606)	Component