RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	CancerCHIKVSARS-COV-OC43FlavivirusesHIVRVSARS-COV-2Dengue
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	Metabolic enzyme
Localizations	Stress granucle
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000054118	Gene ID	9967	Accession	22964
Symbol	THRAP3	Alias	BCLAF2;TRAP150	Full Name	thyroid hormone receptor associated protein 3
Status	Confidence	Length	80926 bases	Strand	Plus strand
Position	1 : 36224432 - 36305357	RNA binding domain	THRAP3_BCLAF1
Summary	Enables phosphoprotein binding activity; thyroid hormone receptor binding activity; and transcription coactivator activity. Involved in nuclear-transcribed mRNA catabolic process; positive regulation of circadian rhythm; and regulation of RNA metabolic process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of mediator complex. Colocalizes with exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000346634	THRAP3_BCLAF1	PF15440	1e-203	1
ENSP00000433825	THRAP3_BCLAF1	PF15440	1e-203	1
ENSP00000498001	THRAP3_BCLAF1	PF15440	8.8e-204	1

Showing 1 to 3 of 3 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hs_HeLa	HeLa	Alfredo Castello?	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
25173706	Pclap_PMID25173706_Hs_HEK293	HEK293	Katharina Kramer	2014 Oct;11	doi: 10.1038/nmeth.3092.?Epub 2014 Aug 31
26632259	RIC_PMID26632259._Hs_HuH7	HuH7	Benedikt M Beckmann	2015 Dec 3	doi: 10.1038/ncomms10127.
27040163	serIC_PMID27040163_Hs_K562	K562	Thomas Conrad?	2016 Apr 4	doi: 10.1038/ncomms11212
27040163	serIC_PMID27040163_Hs_K562.1	K562	Thomas Conrad?	2016 Apr 4	doi: 10.1038/ncomms11212
29431736	RICK_PMID29431736_Hs_HeLa.RICK	HeLa	Xichen Bao	2018 Mar	doi: 10.1038/nmeth.4595.?Epub 2018 Feb 12
29636419	CARIC_PMID29636419_Hs_CARIC		Rongbing Huang	2018 Apr 24	doi: 10.1073/pnas.1718406115
30352994	eRIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
30352994	RIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8

Showing 1 to 10 of 21 entries

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Pubmed ID	Title	Author	Time	Journal
No data available in table

Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
THRAP3-201	ENST00000354618	4405	955aa	ENSP00000346634
THRAP3-202	ENST00000466743	537	No protein	-
THRAP3-203	ENST00000469141	3339	955aa	ENSP00000433825
THRAP3-204	ENST00000648638	3825	910aa	ENSP00000498001

Showing 1 to 4 of 4 entries

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Gene Model

Click here to download ENSG00000054118's gene model file

ensgID	Trait	pValue	Pubmed ID
No data available in table

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
No data available in table

Protein-Protein Interaction (PPI)

Click here to download ENSG00000054118's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000054118	homo_sapiens	ENSP00000435210	52.8261	39.3478	homo_sapiens	ENSP00000346634	50.8901	37.9058
ENSG00000054118	homo_sapiens	ENSP00000369004	37.5527	23.0661	homo_sapiens	ENSP00000346634	27.9581	17.1728

Showing 1 to 2 of 2 entries

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000054118	homo_sapiens	ENSP00000346634	99.7906	99.267	nomascus_leucogenys	ENSNLEP00000013840	99.8952	99.3711
ENSG00000054118	homo_sapiens	ENSP00000346634	99.8953	99.8953	pan_paniscus	ENSPPAP00000011540	100	100
ENSG00000054118	homo_sapiens	ENSP00000346634	99.7906	99.7906	pongo_abelii	ENSPPYP00000041298	99.7906	99.7906
ENSG00000054118	homo_sapiens	ENSP00000346634	100	100	pan_troglodytes	ENSPTRP00000000942	100	100
ENSG00000054118	homo_sapiens	ENSP00000346634	99.8953	99.8953	gorilla_gorilla	ENSGGOP00000006771	99.8953	99.8953
ENSG00000054118	homo_sapiens	ENSP00000346634	93.7173	88.6911	ornithorhynchus_anatinus	ENSOANP00000003281	93.2292	88.2292
ENSG00000054118	homo_sapiens	ENSP00000346634	94.0314	89.5288	sarcophilus_harrisii	ENSSHAP00000023805	92.7686	88.3264
ENSG00000054118	homo_sapiens	ENSP00000346634	49.4241	45.0262	notamacropus_eugenii	ENSMEUP00000014155	62.1053	56.5789
ENSG00000054118	homo_sapiens	ENSP00000346634	81.2565	78.7435	choloepus_hoffmanni	ENSCHOP00000007949	89.093	86.3375
ENSG00000054118	homo_sapiens	ENSP00000346634	98.1152	96.0209	dasypus_novemcinctus	ENSDNOP00000033901	97.8079	95.7203

Showing 1 to 10 of 287 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003712	enables transcription coregulator activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0016592	part_of mediator complex	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0000381	involved_in regulation of alternative mRNA splicing, via spliceosome	1	IMP	Homo_sapiens(9606)	Process
GO:0000956	involved_in nuclear-transcribed mRNA catabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0000978	enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	1	ISS	Homo_sapiens(9606)	Function
GO:0003677	enables DNA binding	1	IBA	Homo_sapiens(9606)	Function
GO:0003713	enables transcription coactivator activity	1	IDA	Homo_sapiens(9606)	Function
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function

Showing 1 to 10 of 27 entries

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression