Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq

Description

Ensembl ID ENSG00000049449 Gene ID 5954 Accession 9934
Symbol RCN1 Alias RCN;RCAL;PIG20;HEL-S-84 Full Name reticulocalbin 1
Status Confidence Length 14649 bases Strand Plus strand
Position 11 : 32091074 - 32105722 RNA binding domain N.A.
Summary Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
RCN1-201 ENST00000054950 2369 331aa ENSP00000054950
RCN1-206 ENST00000532721 494 19aa ENSP00000433249
RCN1-207 ENST00000533898 2416 No protein -
RCN1-205 ENST00000532474 714 No protein -
RCN1-202 ENST00000527337 737 57aa ENSP00000436427
RCN1-204 ENST00000531345 2653 No protein -
RCN1-203 ENST00000528630 549 28aa ENSP00000433237

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
9443Echocardiography3.18247594381643E-517903301
9457Echocardiography9.0404207864519E-517903301
9718Echocardiography9.69904164864764E-517903301
12316Depressive Disorder, Major6.976E-517728769
12322Depressive Disorder, Major5.681E-517728769
36474Platelet Function Tests1.2331600E-005-
46904Platelet Function Tests2.0751000E-005-
60796Gastrointestinal Microbiome4E-626528553
75636Tuberculosis3E-1122306650
103235Tuberculosis3E-624057671
103783Tuberculosis1E-1224057671

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001701involved_in in utero embryonic development1IEAHomo_sapiens(9606)Process
GO:0005509enables calcium ion binding1IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005783is_active_in endoplasmic reticulum2IBA,IDAHomo_sapiens(9606)Component
GO:0005788located_in endoplasmic reticulum lumen1TASHomo_sapiens(9606)Component
GO:0043010involved_in camera-type eye development1IEAHomo_sapiens(9606)Process

Expression