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RBP World!
Functions and Diseases
| RBP Type | Non-canonical_RBPs |
| Diseases | CancerFlavivirusesSARS-COV-2DengueZika |
| Drug | N.A. |
| Main interacting RNAs | N.A. |
| Moonlighting functions | N.A. |
| Localizations | N.A. |
| BulkPerturb-seq | N.A. |
Description
| Ensembl ID | ENSG00000044574 | Gene ID | 3309 | Accession | 5238 |
| Symbol | HSPA5 | Alias | BIP;GRP78;HEL-S-89n | Full Name | heat shock protein family A (Hsp70) member 5 |
| Status | Confidence | Length | 6530 bases | Strand | Minus strand |
| Position | 9 : 125234853 - 125241382 | RNA binding domain | N.A. | ||
| Summary | The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020] | ||||
RNA binding domains (RBDs)
| Protein | Domain | Pfam ID | E-value | Domain number |
|---|
RNA binding proteomes (RBPomes)
| Pubmed ID | Full Name | Cell | Author | Time | Doi |
|---|
Literatures on RNA binding capacity
| Pubmed ID | Title | Author | Time | Journal |
|---|---|---|---|---|
| 35872700 | HSPA5 Inhibitor Meliorate DSS-Induced Colitis through HSPA1A/CHIP. | Fei Gao | 2022-01-01 | Disease markers |
| 37156995 | Identification of heat shock protein family A member 5 (HSPA5) targets involved in nonalcoholic fatty liver disease. | Aliya Rehati | 2023-06-01 | Genes and immunity |
| 35581326 | Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology. | Liberty François-Moutal | 2022-05-17 | Scientific reports |
Transcripts
| Name | Transcript ID | bp | Protein | Translation ID |
|---|---|---|---|---|
| HSPA5-201 | ENST00000324460 | 3921 | 654aa | ENSP00000324173 |
| HSPA5-209 | ENST00000680640 | 4929 | No protein | - |
| HSPA5-203 | ENST00000679475 | 4281 | No protein | - |
| HSPA5-208 | ENST00000680494 | 5402 | No protein | - |
| HSPA5-215 | ENST00000681774 | 4919 | No protein | - |
| HSPA5-202 | ENST00000679355 | 4052 | No protein | - |
| HSPA5-210 | ENST00000681045 | 4858 | No protein | - |
| HSPA5-211 | ENST00000681424 | 4333 | No protein | - |
| HSPA5-214 | ENST00000681675 | 4577 | No protein | - |
| HSPA5-213 | ENST00000681544 | 4028 | No protein | - |
| HSPA5-207 | ENST00000680272 | 3825 | 616aa | ENSP00000506097 |
| HSPA5-206 | ENST00000680257 | 4234 | No protein | - |
| HSPA5-204 | ENST00000680032 | 2231 | 623aa | ENSP00000506285 |
| HSPA5-212 | ENST00000681540 | 3518 | No protein | - |
| HSPA5-205 | ENST00000680234 | 3221 | No protein | - |
Phenotypes
| ensgID | Trait | pValue | Pubmed ID |
|---|---|---|---|
| 42156 | Platelet Function Tests | 2.0793200E-005 | - |
| 42230 | Platelet Function Tests | 4.8557778E-006 | - |
| 42235 | Platelet Function Tests | 4.9138553E-006 | - |
| 42237 | Platelet Function Tests | 4.7551428E-006 | - |
GWAS
| ensgID | SNP | Chromosome | Position | Trait | PubmedID | Or or BEAT | EFO ID |
|---|
Protein-Protein Interaction (PPI)
Paralogs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
| ENSG00000044574 | homo_sapiens | ENSP00000367623 | 56.9745 | 34.7741 | homo_sapiens | ENSP00000324173 | 44.3425 | 27.0642 |
| ENSG00000044574 | homo_sapiens | ENSP00000285667 | 54.9894 | 36.3057 | homo_sapiens | ENSP00000324173 | 39.6024 | 26.1468 |
| ENSG00000044574 | homo_sapiens | ENSP00000297185 | 64.5066 | 48.6009 | homo_sapiens | ENSP00000324173 | 66.9725 | 50.4587 |
| ENSG00000044574 | homo_sapiens | ENSP00000480150 | 32.1321 | 18.2182 | homo_sapiens | ENSP00000324173 | 49.0826 | 27.8287 |
| ENSG00000044574 | homo_sapiens | ENSP00000364805 | 78.4711 | 62.8705 | homo_sapiens | ENSP00000324173 | 76.9113 | 61.6208 |
| ENSG00000044574 | homo_sapiens | ENSP00000247207 | 78.4038 | 62.9108 | homo_sapiens | ENSP00000324173 | 76.6055 | 61.4679 |
| ENSG00000044574 | homo_sapiens | ENSP00000310219 | 77.2939 | 60.6532 | homo_sapiens | ENSP00000324173 | 75.9939 | 59.633 |
| ENSG00000044574 | homo_sapiens | ENSP00000302961 | 41.1905 | 25.119 | homo_sapiens | ENSP00000324173 | 52.9052 | 32.263 |
| ENSG00000044574 | homo_sapiens | ENSP00000318687 | 39.1608 | 23.7762 | homo_sapiens | ENSP00000324173 | 51.3761 | 31.1927 |
| ENSG00000044574 | homo_sapiens | ENSP00000432083 | 79.8762 | 64.3963 | homo_sapiens | ENSP00000324173 | 78.8991 | 63.6086 |
| ENSG00000044574 | homo_sapiens | ENSP00000296464 | 40.7628 | 22.8844 | homo_sapiens | ENSP00000324173 | 52.2936 | 29.3578 |
| ENSG00000044574 | homo_sapiens | ENSP00000364801 | 78.6271 | 62.2465 | homo_sapiens | ENSP00000324173 | 77.0642 | 61.0092 |
| ENSG00000044574 | homo_sapiens | ENSP00000364802 | 78.6271 | 62.2465 | homo_sapiens | ENSP00000324173 | 77.0642 | 61.0092 |
Orthologs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 99.2355 | nomascus_leucogenys | ENSNLEP00000021061 | 99.3884 | 99.2355 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 100 | 100 | pan_paniscus | ENSPPAP00000040660 | 100 | 100 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 100 | 100 | pongo_abelii | ENSPPYP00000021973 | 100 | 100 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 100 | 100 | pan_troglodytes | ENSPTRP00000000984 | 100 | 100 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 100 | 100 | gorilla_gorilla | ENSGGOP00000023678 | 100 | 100 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.1651 | 96.4832 | ornithorhynchus_anatinus | ENSOANP00000020985 | 94.2731 | 92.6579 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.1651 | 96.4832 | sarcophilus_harrisii | ENSSHAP00000039410 | 98.0153 | 96.3359 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 82.5688 | 81.8043 | notamacropus_eugenii | ENSMEUP00000015264 | 98.5401 | 97.6277 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 73.3945 | 73.2416 | dasypus_novemcinctus | ENSDNOP00000020194 | 99.3789 | 99.1718 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 74.9235 | 74.7706 | echinops_telfairi | ENSETEP00000014520 | 81.5308 | 81.3644 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.5413 | 99.3884 | callithrix_jacchus | ENSCJAP00000012786 | 99.5413 | 99.3884 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 100 | 100 | cercocebus_atys | ENSCATP00000044399 | 100 | 100 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 100 | 100 | macaca_fascicularis | ENSMFAP00000041902 | 100 | 100 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 100 | 100 | macaca_mulatta | ENSMMUP00000006906 | 100 | 100 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 100 | 100 | macaca_nemestrina | ENSMNEP00000005194 | 100 | 100 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 100 | 100 | papio_anubis | ENSPANP00000033322 | 100 | 100 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 100 | 100 | mandrillus_leucophaeus | ENSMLEP00000022843 | 100 | 100 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.2355 | 98.4709 | tursiops_truncatus | ENSTTRP00000016490 | 99.2355 | 98.4709 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.0826 | vulpes_vulpes | ENSVVUP00000013744 | 99.6942 | 99.0826 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.2355 | 98.6239 | mus_spretus | MGP_SPRETEiJ_P0053371 | 99.084 | 98.4733 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.0826 | equus_asinus | ENSEASP00005030308 | 99.6942 | 99.0826 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.5413 | 98.9297 | capra_hircus | ENSCHIP00000030268 | 99.3893 | 98.7786 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 98.9297 | loxodonta_africana | ENSLAFP00000008418 | 99.542 | 98.7786 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.0826 | panthera_leo | ENSPLOP00000018565 | 99.6942 | 99.0826 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.0826 | ailuropoda_melanoleuca | ENSAMEP00000017525 | 99.6942 | 99.0826 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 98.7768 | bos_indicus_hybrid | ENSBIXP00005013545 | 99.2366 | 98.626 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.6239 | 98.4709 | oryctolagus_cuniculus | ENSOCUP00000029180 | 99.6909 | 99.5363 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.0826 | equus_caballus | ENSECAP00000021754 | 99.6942 | 99.0826 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.0826 | canis_lupus_familiaris | ENSCAFP00845013043 | 99.6942 | 99.0826 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.0826 | panthera_pardus | ENSPPRP00000029468 | 99.6942 | 99.0826 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.8471 | 99.2355 | marmota_marmota_marmota | ENSMMMP00000020329 | 99.6947 | 99.084 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 98.4709 | balaenoptera_musculus | ENSBMSP00010003909 | 99.2366 | 98.3206 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 82.8746 | 77.8287 | cavia_porcellus | ENSCPOP00000032160 | 88.9984 | 83.5796 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.3884 | cavia_porcellus | ENSCPOP00000011266 | 99.542 | 99.2366 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.0826 | felis_catus | ENSFCAP00000010964 | 99.6942 | 99.0826 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.0826 | ursus_americanus | ENSUAMP00000018212 | 99.6942 | 99.0826 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.318 | 96.6361 | monodelphis_domestica | ENSMODP00000024667 | 97.8691 | 96.1948 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 98.7768 | bison_bison_bison | ENSBBBP00000006601 | 99.2366 | 98.626 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 98.4709 | monodon_monoceros | ENSMMNP00015026800 | 99.2366 | 98.3206 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 95.5658 | 94.3425 | sus_scrofa | ENSSSCP00000055982 | 95.1294 | 93.9117 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.5413 | 99.2355 | microcebus_murinus | ENSMICP00000002682 | 99.3893 | 99.084 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.5413 | 99.2355 | octodon_degus | ENSODEP00000004880 | 99.3893 | 99.084 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.2355 | 99.0826 | jaculus_jaculus | ENSJJAP00000023507 | 98.9329 | 98.7805 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 98.7768 | ovis_aries_rambouillet | ENSOARP00020009701 | 99.2366 | 98.626 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.0826 | ursus_maritimus | ENSUMAP00000002482 | 99.6942 | 99.0826 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 98.4709 | delphinapterus_leucas | ENSDLEP00000021233 | 99.2366 | 98.3206 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 98.6239 | physeter_catodon | ENSPCTP00005016705 | 99.2366 | 98.4733 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.2355 | 98.6239 | mus_caroli | MGP_CAROLIEiJ_P0051326 | 99.084 | 98.4733 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.2355 | 98.6239 | mus_musculus | ENSMUSP00000028222 | 99.084 | 98.4733 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 99.0826 | dipodomys_ordii | ENSDORP00000013559 | 99.0854 | 98.7805 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.0826 | mustela_putorius_furo | ENSMPUP00000013783 | 99.6942 | 99.0826 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.5413 | 99.5413 | aotus_nancymaae | ENSANAP00000042461 | 99.5413 | 99.5413 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.2355 | 99.2355 | saimiri_boliviensis_boliviensis | ENSSBOP00000012334 | 99.2355 | 99.2355 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 89.7553 | 89.1437 | vicugna_pacos | ENSVPAP00000008631 | 89.7553 | 89.1437 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 100 | 100 | chlorocebus_sabaeus | ENSCSAP00000009792 | 100 | 100 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 78.7462 | 78.2875 | tupaia_belangeri | ENSTBEP00000000838 | 78.7462 | 78.2875 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 98.6239 | mesocricetus_auratus | ENSMAUP00000018102 | 99.0854 | 98.3232 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 98.4709 | phocoena_sinus | ENSPSNP00000019806 | 99.2366 | 98.3206 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.5413 | 98.9297 | camelus_dromedarius | ENSCDRP00005023885 | 99.5413 | 98.9297 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.2355 | carlito_syrichta | ENSTSYP00000017803 | 99.542 | 99.084 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.0826 | panthera_tigris_altaica | ENSPTIP00000008507 | 99.6942 | 99.0826 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.0826 | 98.4709 | rattus_norvegicus | ENSRNOP00000025064 | 98.9313 | 98.3206 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.5413 | prolemur_simus | ENSPSMP00000034548 | 99.6942 | 99.5413 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 98.7768 | microtus_ochrogaster | ENSMOCP00000000914 | 99.2366 | 98.626 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.2355 | 98.4709 | peromyscus_maniculatus_bairdii | ENSPEMP00000025268 | 99.084 | 98.3206 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 98.7768 | bos_mutus | ENSBMUP00000027042 | 99.2366 | 98.626 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.2355 | 98.6239 | mus_spicilegus | ENSMSIP00000017902 | 99.084 | 98.4733 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.2355 | 98.7768 | cricetulus_griseus_chok1gshd | ENSCGRP00001012335 | 99.084 | 98.626 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 69.8777 | 69.2661 | pteropus_vampyrus | ENSPVAP00000007652 | 69.8777 | 69.2661 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.5413 | 98.6239 | myotis_lucifugus | ENSMLUP00000008696 | 99.3893 | 98.4733 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.318 | 96.6361 | vombatus_ursinus | ENSVURP00010012463 | 97.2769 | 95.6127 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.318 | 96.6361 | vombatus_ursinus | ENSVURP00010022961 | 97.2769 | 95.6127 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.5413 | 98.6239 | rhinolophus_ferrumequinum | ENSRFEP00010017758 | 99.5413 | 98.6239 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.0826 | neovison_vison | ENSNVIP00000007569 | 99.6942 | 99.0826 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 98.7768 | bos_taurus | ENSBTAP00000052422 | 99.2366 | 98.626 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.2355 | heterocephalus_glaber_female | ENSHGLP00000055646 | 99.542 | 99.084 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 71.4067 | 71.4067 | rhinopithecus_bieti | ENSRBIP00000043186 | 100 | 100 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.0826 | canis_lupus_dingo | ENSCAFP00020019709 | 99.6942 | 99.0826 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.8471 | 99.3884 | sciurus_vulgaris | ENSSVLP00005028706 | 99.8471 | 99.3884 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.4709 | 96.789 | phascolarctos_cinereus | ENSPCIP00000024211 | 98.0213 | 96.347 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 79.9694 | 79.3578 | procavia_capensis | ENSPCAP00000013348 | 79.9694 | 79.3578 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.2355 | 98.7768 | nannospalax_galili | ENSNGAP00000015524 | 98.9329 | 98.4756 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 98.7768 | bos_grunniens | ENSBGRP00000031822 | 99.2366 | 98.626 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.3884 | chinchilla_lanigera | ENSCLAP00000014221 | 99.542 | 99.2366 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.2355 | 98.7768 | cervus_hanglu_yarkandensis | ENSCHYP00000019384 | 99.084 | 98.626 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.5413 | 98.7768 | catagonus_wagneri | ENSCWAP00000020567 | 99.5413 | 98.7768 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.8471 | 99.2355 | ictidomys_tridecemlineatus | ENSSTOP00000010092 | 99.8471 | 99.2355 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.8471 | 99.6942 | otolemur_garnettii | ENSOGAP00000006071 | 99.6947 | 99.542 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.5413 | cebus_imitator | ENSCCAP00000022508 | 99.6942 | 99.5413 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 98.9297 | urocitellus_parryii | ENSUPAP00010017094 | 99.6942 | 98.9297 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.3884 | 98.7768 | moschus_moschiferus | ENSMMSP00000024569 | 99.2366 | 98.626 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 100 | 100 | rhinopithecus_roxellana | ENSRROP00000008593 | 100 | 100 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.2355 | 98.6239 | mus_pahari | MGP_PahariEiJ_P0062342 | 99.084 | 98.4733 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.3303 | 95.107 | propithecus_coquereli | ENSPCOP00000009246 | 97.0724 | 95.8398 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 99.6942 | 99.5413 | propithecus_coquereli | ENSPCOP00000026905 | 99.6942 | 99.5413 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 89.9083 | 78.2875 | caenorhabditis_elegans | C15H9.6a.2 | 88.9561 | 77.4584 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 89.1437 | 75.841 | caenorhabditis_elegans | F43E2.8a.2 | 88.7367 | 75.4947 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 89.9083 | 81.0398 | drosophila_melanogaster | FBpp0073447 | 89.6341 | 80.7927 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 84.4037 | 70.1835 | ciona_intestinalis | ENSCINP00000019205 | 82.2653 | 68.4054 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 88.8379 | 79.9694 | ciona_intestinalis | ENSCINP00000019494 | 88.1639 | 79.3627 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 94.9541 | 86.8502 | petromyzon_marinus | ENSPMAP00000005081 | 93.6652 | 85.6712 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 89.9083 | 81.9572 | eptatretus_burgeri | ENSEBUP00000005600 | 94.382 | 86.0353 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 94.4954 | 90.0612 | callorhinchus_milii | ENSCMIP00000008220 | 93.6364 | 89.2424 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 97.7064 | 94.9541 | latimeria_chalumnae | ENSLACP00000020775 | 97.7064 | 94.9541 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 97.2477 | 92.6606 | lepisosteus_oculatus | ENSLOCP00000005999 | 96.2178 | 91.6793 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 93.4251 | 86.2385 | clupea_harengus | ENSCHAP00000012252 | 94.1448 | 86.9029 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 95.2599 | 90.0612 | clupea_harengus | ENSCHAP00000011930 | 94.825 | 89.6499 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.1774 | 91.7431 | danio_rerio | ENSDARP00000131952 | 96.7692 | 92.3077 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 93.1193 | 86.2385 | carassius_auratus | ENSCARP00000009753 | 91.1677 | 84.4311 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.0245 | 91.2844 | carassius_auratus | ENSCARP00000009635 | 95.8779 | 91.145 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.3303 | 92.2018 | carassius_auratus | ENSCARP00000112911 | 94.0299 | 90 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.6361 | 92.0489 | astyanax_mexicanus | ENSAMXP00000009267 | 96.6361 | 92.0489 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.0245 | 91.4373 | ictalurus_punctatus | ENSIPUP00000029142 | 96.319 | 91.7178 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.4832 | 91.2844 | esox_lucius | ENSELUP00000014504 | 96.6309 | 91.4242 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.4832 | 91.4373 | electrophorus_electricus | ENSEEEP00000034832 | 94.8872 | 89.9248 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 95.7187 | 89.7553 | oncorhynchus_kisutch | ENSOKIP00005026481 | 95.2816 | 89.3455 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.6361 | 91.2844 | oncorhynchus_kisutch | ENSOKIP00005073680 | 95.7576 | 90.4545 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.6361 | 91.1315 | oncorhynchus_mykiss | ENSOMYP00000088627 | 95.7576 | 90.303 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 95.2599 | 89.6024 | oncorhynchus_mykiss | ENSOMYP00000063562 | 95.1145 | 89.4657 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 94.0367 | 88.2263 | salmo_salar | ENSSSAP00000057646 | 84.7107 | 79.4766 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 95.107 | 90.0612 | salmo_salar | ENSSSAP00000036877 | 95.5453 | 90.4762 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 90.367 | 84.5566 | salmo_trutta | ENSSTUP00000014339 | 92.4883 | 86.5415 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.6361 | 91.1315 | salmo_trutta | ENSSTUP00000046388 | 95.7576 | 90.303 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.1774 | 91.5902 | gadus_morhua | ENSGMOP00000030132 | 95.303 | 90.7576 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.6361 | 91.2844 | fundulus_heteroclitus | ENSFHEP00000003387 | 96.9325 | 91.5644 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.9419 | 92.0489 | poecilia_reticulata | ENSPREP00000023630 | 97.2393 | 92.3313 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.789 | 92.0489 | xiphophorus_maculatus | ENSXMAP00000005698 | 97.0859 | 92.3313 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.789 | 92.0489 | oryzias_latipes | ENSORLP00000036380 | 96.9372 | 92.1899 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 95.2599 | 90.367 | cyclopterus_lumpus | ENSCLMP00005024727 | 93.5435 | 88.7387 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 88.0734 | 79.5107 | oreochromis_niloticus | ENSONIP00000041134 | 90.7087 | 81.8898 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 88.3792 | 80.8868 | oreochromis_niloticus | ENSONIP00000069865 | 86.7868 | 79.4294 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 45.5658 | 41.1315 | oreochromis_niloticus | ENSONIP00000000455 | 89.4895 | 80.7808 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 95.7187 | 90.9786 | oreochromis_niloticus | ENSONIP00000031363 | 91.6545 | 87.1157 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 88.685 | 80.7339 | oreochromis_niloticus | ENSONIP00000043499 | 91.3386 | 83.1496 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 14.526 | 13.4557 | haplochromis_burtoni | ENSHBUP00000034214 | 84.8214 | 78.5714 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.6361 | 91.4373 | haplochromis_burtoni | ENSHBUP00000020005 | 96.7841 | 91.5773 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.6361 | 91.5902 | astatotilapia_calliptera | ENSACLP00000016033 | 89.6454 | 84.9645 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 86.2385 | 78.5933 | astatotilapia_calliptera | ENSACLP00000039549 | 85.9756 | 78.3537 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.4832 | 91.4373 | astatotilapia_calliptera | ENSACLP00000016109 | 96.6309 | 91.5773 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.3303 | 91.7431 | sparus_aurata | ENSSAUP00010019818 | 95.1662 | 90.6344 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 94.6483 | 90.367 | lates_calcarifer | ENSLCAP00010017346 | 93.9302 | 89.6813 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 94.8012 | 91.4373 | xenopus_tropicalis | ENSXETP00000116648 | 91.0426 | 87.812 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.4709 | 96.3303 | chrysemys_picta_bellii | ENSCPBP00000041010 | 99.0769 | 96.9231 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 97.8593 | 94.3425 | sphenodon_punctatus | ENSSPUP00000000907 | 98.3103 | 94.7773 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 97.8593 | 96.0245 | crocodylus_porosus | ENSCPRP00005015493 | 97.8593 | 96.0245 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 97.4006 | 94.4954 | laticauda_laticaudata | ENSLLTP00000018023 | 97.4006 | 94.4954 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 97.8593 | 94.8012 | notechis_scutatus | ENSNSUP00000008220 | 97.7099 | 94.6565 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 97.7064 | 94.6483 | pseudonaja_textilis | ENSPTXP00000020734 | 97.5573 | 94.5038 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.7768 | 96.6361 | anas_platyrhynchos_platyrhynchos | ENSAPLP00000002711 | 99.0798 | 96.9325 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.6239 | 96.4832 | gallus_gallus | ENSGALP00010041529 | 98.9264 | 96.7791 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 94.3425 | 92.0489 | meleagris_gallopavo | ENSMGAP00000022961 | 95.0693 | 92.7581 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 94.6483 | 92.3547 | serinus_canaria | ENSSCAP00000022421 | 95.8204 | 93.4985 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 95.107 | 92.9664 | parus_major | ENSPMJP00000026209 | 85.2055 | 83.2877 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 97.0948 | 93.8838 | anolis_carolinensis | ENSACAP00000004078 | 96.9466 | 93.7405 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 47.4006 | 44.4954 | neolamprologus_brichardi | ENSNBRP00000009356 | 94.5122 | 88.7195 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 42.2018 | 38.8379 | neolamprologus_brichardi | ENSNBRP00000009431 | 84.4037 | 77.6758 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 51.0703 | 47.0948 | neolamprologus_brichardi | ENSNBRP00000024650 | 85.8612 | 79.1774 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 97.2477 | 94.4954 | naja_naja | ENSNNAP00000008401 | 97.2477 | 94.4954 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 97.8593 | 94.8012 | podarcis_muralis | ENSPMRP00000036987 | 97.8593 | 94.8012 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 93.4251 | 91.896 | geospiza_fortis | ENSGFOP00000003568 | 96.6772 | 95.0949 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.1651 | 96.0245 | taeniopygia_guttata | ENSTGUP00000007517 | 98.3155 | 96.1715 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.4832 | 92.6606 | erpetoichthys_calabaricus | ENSECRP00000024969 | 96.7791 | 92.9448 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.3303 | 91.1315 | kryptolebias_marmoratus | ENSKMAP00000021824 | 96.4778 | 91.2711 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 97.7064 | 95.107 | salvator_merianae | ENSSMRP00000010046 | 98.0061 | 95.3988 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 90.6728 | 86.2385 | oryzias_javanicus | ENSOJAP00000030909 | 92.8013 | 88.2629 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 44.4954 | 42.3547 | amphilophus_citrinellus | ENSACIP00000025625 | 92.9712 | 88.4984 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.1774 | 91.896 | dicentrarchus_labrax | ENSDLAP00005002563 | 95.7382 | 91.4764 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.6361 | 92.2018 | amphiprion_percula | ENSAPEP00000021979 | 96.6361 | 92.2018 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 48.9297 | 45.8716 | amphiprion_percula | ENSAPEP00000022036 | 87.1935 | 81.7439 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.4832 | 91.4373 | oryzias_sinensis | ENSOSIP00000030474 | 95.7511 | 90.7436 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 92.5076 | 90.8257 | pelodiscus_sinensis | ENSPSIP00000005890 | 98.6949 | 96.9005 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.6239 | 96.1774 | gopherus_evgoodei | ENSGEVP00005009159 | 87.8747 | 85.6948 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.1651 | 95.8716 | chelonoidis_abingdonii | ENSCABP00000000426 | 97.7169 | 95.4338 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 95.7187 | 90.8257 | seriola_dumerili | ENSSDUP00000032656 | 95.7187 | 90.8257 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.1774 | 92.0489 | cottoperca_gobio | ENSCGOP00000054688 | 95.1589 | 91.0741 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 92.9664 | 91.5902 | struthio_camelus_australis | ENSSCUP00000021250 | 99.0228 | 97.557 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 93.578 | 91.896 | anser_brachyrhynchus | ENSABRP00000026827 | 99.1896 | 97.4068 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.1774 | 91.896 | gasterosteus_aculeatus | ENSGACP00000021969 | 94.4444 | 90.2402 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.3303 | 92.2018 | cynoglossus_semilaevis | ENSCSEP00000027564 | 96.1832 | 92.0611 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.789 | 91.7431 | poecilia_formosa | ENSPFOP00000019977 | 97.0859 | 92.0245 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.4832 | 91.4373 | myripristis_murdjan | ENSMMDP00005035746 | 95.0301 | 90.0602 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 93.7309 | 87.6147 | myripristis_murdjan | ENSMMDP00005035529 | 94.1628 | 88.0184 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.3303 | 91.896 | sander_lucioperca | ENSSLUP00000026643 | 95.4545 | 91.0606 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.6239 | 96.4832 | strigops_habroptila | ENSSHBP00005015775 | 95.2733 | 93.2053 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.4832 | 92.2018 | amphiprion_ocellaris | ENSAOCP00000026582 | 96.4832 | 92.2018 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.789 | 95.107 | terrapene_carolina_triunguis | ENSTMTP00000022461 | 97.0859 | 95.3988 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.4832 | 91.1315 | hucho_hucho | ENSHHUP00000016274 | 95.7511 | 90.4401 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.0245 | 90.6728 | hucho_hucho | ENSHHUP00000006139 | 95.586 | 90.2588 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 95.8716 | 91.1315 | betta_splendens | ENSBSLP00000039721 | 95.4338 | 90.7154 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.789 | 91.896 | pygocentrus_nattereri | ENSPNAP00000036248 | 96.9372 | 92.0368 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 97.2477 | 92.9664 | anabas_testudineus | ENSATEP00000062398 | 96.8036 | 92.5419 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 88.8379 | 79.9694 | ciona_savignyi | ENSCSAVP00000010977 | 88.4323 | 79.6043 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.9419 | 92.3547 | seriola_lalandi_dorsalis | ENSSLDP00000010861 | 96.9419 | 92.3547 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 93.7309 | 87.7676 | labrus_bergylta | ENSLBEP00000005789 | 91.3562 | 85.544 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 43.8838 | 40.8257 | labrus_bergylta | ENSLBEP00000027932 | 83.9181 | 78.0702 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.0245 | 90.8257 | labrus_bergylta | ENSLBEP00000028117 | 96.0245 | 90.8257 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 70.4893 | 66.055 | labrus_bergylta | ENSLBEP00000012249 | 94.0816 | 88.1633 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 93.7309 | 88.8379 | labrus_bergylta | ENSLBEP00000005736 | 95.4829 | 90.4984 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 22.9358 | 21.2538 | labrus_bergylta | ENSLBEP00000014437 | 90.9091 | 84.2424 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 91.4373 | 86.0856 | labrus_bergylta | ENSLBEP00000000720 | 91.2977 | 85.9542 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 93.1193 | 87.6147 | labrus_bergylta | ENSLBEP00000036435 | 93.1193 | 87.6147 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 93.2722 | 87.9205 | labrus_bergylta | ENSLBEP00000036400 | 93.415 | 88.0551 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 89.1437 | 83.792 | labrus_bergylta | ENSLBEP00000036456 | 94.4895 | 88.8169 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 51.8349 | 49.3884 | labrus_bergylta | ENSLBEP00000038778 | 87.5969 | 83.4625 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 92.3547 | 87.156 | labrus_bergylta | ENSLBEP00000000610 | 95.1181 | 89.7638 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.1774 | 91.5902 | labrus_bergylta | ENSLBEP00000005564 | 96.1774 | 91.5902 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 16.208 | 14.9847 | labrus_bergylta | ENSLBEP00000007512 | 85.4839 | 79.0323 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 94.1896 | 89.1437 | pundamilia_nyererei | ENSPNYP00000032087 | 97.3144 | 92.1011 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 18.1957 | 16.8196 | pundamilia_nyererei | ENSPNYP00000012236 | 89.4737 | 82.7068 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.9419 | 92.6606 | mastacembelus_armatus | ENSMAMP00000020155 | 96.3526 | 92.0973 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 95.2599 | 90.5199 | stegastes_partitus | ENSSPAP00000021929 | 90.8163 | 86.2974 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 95.4128 | 89.6024 | oncorhynchus_tshawytscha | ENSOTSP00005025092 | 94.9772 | 89.1933 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.6361 | 91.1315 | oncorhynchus_tshawytscha | ENSOTSP00005072968 | 94.8949 | 89.4895 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.6361 | 91.1315 | oncorhynchus_tshawytscha | ENSOTSP00005047124 | 94.8949 | 89.4895 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 14.9847 | 13.7615 | acanthochromis_polyacanthus | ENSAPOP00000032752 | 86.7257 | 79.646 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 14.9847 | 13.7615 | acanthochromis_polyacanthus | ENSAPOP00000017542 | 86.7257 | 79.646 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 46.3303 | 43.578 | acanthochromis_polyacanthus | ENSAPOP00000013571 | 90.4478 | 85.0746 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 16.8196 | 15.7492 | acanthochromis_polyacanthus | ENSAPOP00000030085 | 78.0142 | 73.0496 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 13.6086 | 12.3853 | acanthochromis_polyacanthus | ENSAPOP00000030068 | 72.9508 | 66.3934 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.4709 | 96.9419 | aquila_chrysaetos_chrysaetos | ENSACCP00020023968 | 98.9247 | 97.3886 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.4832 | 91.7431 | nothobranchius_furzeri | ENSNFUP00015044413 | 95.7511 | 91.047 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.6361 | 92.3547 | cyprinodon_variegatus | ENSCVAP00000029709 | 96.9325 | 92.638 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.9419 | 91.7431 | denticeps_clupeoides | ENSDCDP00000003271 | 96.3526 | 91.1854 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.4832 | 92.3547 | larimichthys_crocea | ENSLCRP00005042952 | 91.9825 | 88.0466 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 95.5658 | 90.8257 | takifugu_rubripes | ENSTRUP00000088063 | 94.697 | 90 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.0122 | 95.8716 | ficedula_albicollis | ENSFALP00000002269 | 98.4639 | 96.3134 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.3303 | 91.7431 | hippocampus_comes | ENSHCOP00000001935 | 96.9231 | 92.3077 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.3303 | 91.896 | cyprinus_carpio_carpio | ENSCCRP00000116044 | 95.5994 | 91.1988 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 94.3425 | 88.9908 | cyprinus_carpio_carpio | ENSCCRP00000162641 | 92.6426 | 87.3874 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 98.6239 | 96.3303 | coturnix_japonica | ENSCJPP00005013089 | 98.9264 | 96.6258 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.789 | 91.896 | poecilia_latipinna | ENSPLAP00000019917 | 97.0859 | 92.1779 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 95.8716 | 91.5902 | sinocyclocheilus_grahami | ENSSGRP00000029975 | 92.8889 | 88.7407 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 44.1896 | 40.9786 | sinocyclocheilus_grahami | ENSSGRP00000020588 | 89.4737 | 82.9721 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 95.8716 | 91.2844 | sinocyclocheilus_grahami | ENSSGRP00000035858 | 95.4338 | 90.8676 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 93.8838 | 87.0031 | sinocyclocheilus_grahami | ENSSGRP00000036274 | 92.054 | 85.3073 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.6361 | 91.5902 | maylandia_zebra | ENSMZEP00005026069 | 96.6361 | 91.5902 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 88.685 | 79.6636 | maylandia_zebra | ENSMZEP00005035555 | 90.2022 | 81.0264 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 87.3089 | 78.2875 | maylandia_zebra | ENSMZEP00005034529 | 89.6389 | 80.3768 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 96.6361 | 91.4373 | maylandia_zebra | ENSMZEP00005026057 | 96.7841 | 91.5773 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 94.9541 | 90.6728 | tetraodon_nigroviridis | ENSTNIP00000021926 | 95.8333 | 91.5123 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 90.0612 | 79.8165 | paramormyrops_kingsleyae | ENSPKIP00000020366 | 90.0612 | 79.8165 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 97.4006 | 92.2018 | paramormyrops_kingsleyae | ENSPKIP00000024116 | 97.4006 | 92.2018 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 92.2018 | 85.1682 | scleropages_formosus | ENSSFOP00015048899 | 92.2018 | 85.1682 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 97.4006 | 92.0489 | scleropages_formosus | ENSSFOP00015070065 | 97.1037 | 91.7683 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 92.3547 | 85.474 | scleropages_formosus | ENSSFOP00015045656 | 92.3547 | 85.474 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 94.9541 | 90.9786 | leptobrachium_leishanense | ENSLLEP00000039322 | 88.8412 | 85.1216 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 93.8838 | 89.4495 | scophthalmus_maximus | ENSSMAP00000043038 | 96.0876 | 91.5493 |
| ENSG00000044574 | homo_sapiens | ENSP00000324173 | 94.1896 | 89.4495 | oryzias_melastigma | ENSOMEP00000003704 | 92.3538 | 87.7061 |
Gene Ontology
| Go ID | Go term | No. evidence | Entries | Species | Category |
|---|---|---|---|---|---|
| GO:0005509 | enables calcium ion binding | 1 | TAS | Homo_sapiens(9606) | Function |
| GO:0005515 | enables protein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0005524 | enables ATP binding | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0005634 | located_in nucleus | 3 | HDA,IBA,IMP | Homo_sapiens(9606) | Component |
| GO:0005737 | is_active_in cytoplasm | 2 | IBA,IDA | Homo_sapiens(9606) | Component |
| GO:0005739 | located_in mitochondrion | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0005783 | located_in endoplasmic reticulum | 3 | IDA,IMP,TAS | Homo_sapiens(9606) | Component |
| GO:0005788 | is_active_in endoplasmic reticulum lumen | 3 | IBA,IDA,TAS | Homo_sapiens(9606) | Component |
| GO:0005789 | located_in endoplasmic reticulum membrane | 2 | IDA,TAS | Homo_sapiens(9606) | Component |
| GO:0005793 | located_in endoplasmic reticulum-Golgi intermediate compartment | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0005829 | located_in cytosol | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0005886 | located_in plasma membrane | 1 | IEA | Homo_sapiens(9606) | Component |
| GO:0005925 | located_in focal adhesion | 1 | HDA | Homo_sapiens(9606) | Component |
| GO:0006983 | involved_in ER overload response | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0009986 | located_in cell surface | 1 | IEA | Homo_sapiens(9606) | Component |
| GO:0016020 | located_in membrane | 2 | HDA,IBA | Homo_sapiens(9606) | Component |
| GO:0016887 | enables ATP hydrolysis activity | 3 | IBA,IDA,ISS | Homo_sapiens(9606) | Function |
| GO:0019899 | enables enzyme binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0019904 | enables protein domain specific binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0021589 | involved_in cerebellum structural organization | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0021680 | involved_in cerebellar Purkinje cell layer development | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0021762 | involved_in substantia nigra development | 1 | HEP | Homo_sapiens(9606) | Process |
| GO:0030335 | involved_in positive regulation of cell migration | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0030433 | involved_in ubiquitin-dependent ERAD pathway | 2 | IBA,TAS | Homo_sapiens(9606) | Process |
| GO:0030496 | located_in midbody | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0030512 | involved_in negative regulation of transforming growth factor beta receptor signaling pathway | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0030968 | involved_in endoplasmic reticulum unfolded protein response | 2 | IBA,TAS | Homo_sapiens(9606) | Process |
| GO:0031072 | enables heat shock protein binding | 1 | IBA | Homo_sapiens(9606) | Function |
| GO:0031204 | involved_in post-translational protein targeting to membrane, translocation | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0031333 | involved_in negative regulation of protein-containing complex assembly | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0031398 | involved_in positive regulation of protein ubiquitination | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0031625 | enables ubiquitin protein ligase binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0032991 | part_of protein-containing complex | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0034663 | part_of endoplasmic reticulum chaperone complex | 2 | IBA,IDA | Homo_sapiens(9606) | Component |
| GO:0034975 | involved_in protein folding in endoplasmic reticulum | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0035437 | involved_in maintenance of protein localization in endoplasmic reticulum | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0042026 | involved_in protein refolding | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0042149 | involved_in cellular response to glucose starvation | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0042470 | located_in melanosome | 1 | IEA | Homo_sapiens(9606) | Component |
| GO:0043022 | enables ribosome binding | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0043066 | involved_in negative regulation of apoptotic process | 2 | IMP,TAS | Homo_sapiens(9606) | Process |
| GO:0043231 | located_in intracellular membrane-bounded organelle | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0044183 | enables protein folding chaperone | 1 | IBA | Homo_sapiens(9606) | Function |
| GO:0045296 | enables cadherin binding | 1 | HDA | Homo_sapiens(9606) | Function |
| GO:0051082 | enables unfolded protein binding | 1 | TAS | Homo_sapiens(9606) | Function |
| GO:0051085 | involved_in chaperone cofactor-dependent protein refolding | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0051087 | enables protein-folding chaperone binding | 1 | TAS | Homo_sapiens(9606) | Function |
| GO:0051787 | enables misfolded protein binding | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0060904 | involved_in regulation of protein folding in endoplasmic reticulum | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0070062 | located_in extracellular exosome | 1 | HDA | Homo_sapiens(9606) | Component |
| GO:0071353 | involved_in cellular response to interleukin-4 | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0140662 | enables ATP-dependent protein folding chaperone | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:1903891 | involved_in regulation of ATF6-mediated unfolded protein response | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:1903894 | involved_in regulation of IRE1-mediated unfolded protein response | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:1903895 | involved_in negative regulation of IRE1-mediated unfolded protein response | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:1903897 | involved_in regulation of PERK-mediated unfolded protein response | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:1990440 | involved_in positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 1 | TAS | Homo_sapiens(9606) | Process |