Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000041982 Gene ID 3371 Accession 5318
Symbol TNC Alias GP;JI;TN;HXB;GMEM;TN-C;DFNA56;150-225 Full Name tenascin C
Status Confidence Length 98633 bases Strand Minus strand
Position 9 : 115019575 - 115118207 RNA binding domain N.A.
Summary This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
TNC-202 ENST00000350763 8500 2201aa ENSP00000265131
TNC-201 ENST00000341037 6786 2019aa ENSP00000339553
TNC-213 ENST00000705190 4126 1182aa ENSP00000516083
TNC-214 ENST00000705191 2782 734aa ENSP00000516084
TNC-215 ENST00000705192 6141 1854aa ENSP00000516085
TNC-209 ENST00000537320 5436 1564aa ENSP00000443478
TNC-203 ENST00000423613 6281 1928aa ENSP00000411406
TNC-210 ENST00000542877 5879 1838aa ENSP00000442242
TNC-211 ENST00000544972 1844 615aa ENSP00000445380
TNC-204 ENST00000460345 651 No protein -
TNC-206 ENST00000476680 761 254aa ENSP00000516086
TNC-205 ENST00000473855 386 129aa ENSP00000516087
TNC-212 ENST00000635336 69 23aa ENSP00000489385
TNC-207 ENST00000481475 823 274aa ENSP00000516088
TNC-208 ENST00000534839 734 92aa ENSP00000443469

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
19875Lymphocyte Count8.956e-005-
71673Eicosapentaenoic Acid3E-626584805
73352Language Disorders3E-627016271
73353Language Tests3E-627016271
81436Depressive Disorder1E-627622933
81437Bupropion1E-627622933
81438Mood Disorders1E-627622933
89626Prostatic Neoplasms4E-622219177
96585Language Disorders4E-627016271
96586Language Tests4E-627016271

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001558involved_in regulation of cell growth1IDAHomo_sapiens(9606)Process
GO:0001649involved_in osteoblast differentiation1HDAHomo_sapiens(9606)Process
GO:0002009involved_in morphogenesis of an epithelium1ISOHomo_sapiens(9606)Process
GO:0005201enables extracellular matrix structural constituent2ISS,RCAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005576located_in extracellular region2HDA,TASHomo_sapiens(9606)Component
GO:0005604located_in basement membrane1ISOHomo_sapiens(9606)Component
GO:0005614located_in interstitial matrix1IEAHomo_sapiens(9606)Component
GO:0005615located_in extracellular space2HDA,IBAHomo_sapiens(9606)Component
GO:0005788located_in endoplasmic reticulum lumen1TASHomo_sapiens(9606)Component
GO:0005925located_in focal adhesion1HDAHomo_sapiens(9606)Component
GO:0007155involved_in cell adhesion1IEAHomo_sapiens(9606)Process
GO:0007162involved_in negative regulation of cell adhesion1IEAHomo_sapiens(9606)Process
GO:0007528involved_in neuromuscular junction development1ISOHomo_sapiens(9606)Process
GO:0008284involved_in positive regulation of cell population proliferation1IEAHomo_sapiens(9606)Process
GO:0009611involved_in response to wounding2IDA,IEPHomo_sapiens(9606)Process
GO:0009612involved_in response to mechanical stimulus1IEAHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression1ISOHomo_sapiens(9606)Process
GO:0014012involved_in peripheral nervous system axon regeneration1ISOHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0030155involved_in regulation of cell adhesion2IBA,IDAHomo_sapiens(9606)Process
GO:0030334involved_in regulation of cell migration1NASHomo_sapiens(9606)Process
GO:0042475involved_in odontogenesis of dentin-containing tooth1IEAHomo_sapiens(9606)Process
GO:0045471involved_in response to ethanol1IEAHomo_sapiens(9606)Process
GO:0045545enables syndecan binding1IDAHomo_sapiens(9606)Function
GO:0050727involved_in regulation of inflammatory response1ISOHomo_sapiens(9606)Process
GO:0060447involved_in bud outgrowth involved in lung branching1IEAHomo_sapiens(9606)Process
GO:0060739involved_in mesenchymal-epithelial cell signaling involved in prostate gland development1IEAHomo_sapiens(9606)Process
GO:0060740involved_in prostate gland epithelium morphogenesis1IEAHomo_sapiens(9606)Process
GO:0062023colocalizes_with collagen-containing extracellular matrix4HDA,IDA,ISSHomo_sapiens(9606)Component
GO:0071300involved_in cellular response to retinoic acid1IEAHomo_sapiens(9606)Process
GO:0071305involved_in cellular response to vitamin D1IEAHomo_sapiens(9606)Process
GO:0071774involved_in response to fibroblast growth factor1IEAHomo_sapiens(9606)Process
GO:0071799involved_in cellular response to prostaglandin D stimulus1IEAHomo_sapiens(9606)Process
GO:0090733part_of tenascin complex1ISOHomo_sapiens(9606)Component
GO:0098966is_active_in perisynaptic extracellular matrix1IBAHomo_sapiens(9606)Component

Expression