RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	KinaseTransmemebrane
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000035664	Gene ID	23604	Accession	2675
Symbol	DAPK2	Alias	DRP1;DRP-1	Full Name	death associated protein kinase 2
Status	Confidence	Length	164998 bases	Strand	Minus strand
Position	15 : 63907036 - 64072033	RNA binding domain	RIO1
Summary	This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000261891	RIO1	PF01163	8e-05	1
ENSP00000408277	RIO1	PF01163	8e-05	1
ENSP00000453235	RIO1	PF01163	0.00011	1
ENSP00000484390	RIO1	PF01163	0.00011	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
DAPK2-201	ENST00000261891	2603	370aa	ENSP00000261891
DAPK2-208	ENST00000559007	4835	91aa	ENSP00000453639
DAPK2-202	ENST00000457488	2791	370aa	ENSP00000408277
DAPK2-210	ENST00000559731	539	No protein	-
DAPK2-204	ENST00000558064	584	48aa	ENSP00000453101
DAPK2-203	ENST00000557867	537	No protein	-
DAPK2-213	ENST00000612884	8086	488aa	ENSP00000484390
DAPK2-205	ENST00000558069	1473	488aa	ENSP00000453235
DAPK2-206	ENST00000558076	484	No protein	-
DAPK2-207	ENST00000558482	909	No protein	-
DAPK2-211	ENST00000559897	570	No protein	-
DAPK2-212	ENST00000561162	566	88aa	ENSP00000453284
DAPK2-209	ENST00000559306	724	80aa	ENSP00000452970

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
87217	Venous Thromboembolism	3E-6	28203683

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004674	enables protein serine/threonine kinase activity	2	IBA,TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005516	enables calmodulin binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005794	located_in Golgi apparatus	1	IDA	Homo_sapiens(9606)	Component
GO:0006468	involved_in protein phosphorylation	1	IDA	Homo_sapiens(9606)	Process
GO:0006915	involved_in apoptotic process	1	TAS	Homo_sapiens(9606)	Process
GO:0010506	involved_in regulation of autophagy	1	TAS	Homo_sapiens(9606)	Process
GO:0031410	located_in cytoplasmic vesicle	1	IEA	Homo_sapiens(9606)	Component
GO:0034423	located_in autophagosome lumen	1	IEA	Homo_sapiens(9606)	Component
GO:0035556	involved_in intracellular signal transduction	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0042981	involved_in regulation of apoptotic process	1	TAS	Homo_sapiens(9606)	Process
GO:0043065	involved_in positive regulation of apoptotic process	1	IBA	Homo_sapiens(9606)	Process
GO:0043231	located_in intracellular membrane-bounded organelle	1	IDA	Homo_sapiens(9606)	Component
GO:0043276	involved_in anoikis	1	IMP	Homo_sapiens(9606)	Process
GO:0046777	involved_in protein autophosphorylation	1	TAS	Homo_sapiens(9606)	Process
GO:0090023	involved_in positive regulation of neutrophil chemotaxis	1	IMP	Homo_sapiens(9606)	Process
GO:0106310	enables protein serine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:2000424	involved_in positive regulation of eosinophil chemotaxis	1	IMP	Homo_sapiens(9606)	Process
GO:2001242	involved_in regulation of intrinsic apoptotic signaling pathway	1	IMP	Homo_sapiens(9606)	Process