Welcome to
RBP World!
Functions and Diseases
| RBP Type | Non-canonical_RBPs |
| Diseases | N.A. |
| Drug | Drug |
| Main interacting RNAs | N.A. |
| Moonlighting functions | Metabolic enzyme |
| Localizations | N.A. |
| BulkPerturb-seq |
Description
| Ensembl ID | ENSG00000026508 | Gene ID | 960 | Accession | 1681 |
| Symbol | CD44 | Alias | IN;LHR;MC56;MDU2;MDU3;MIC4;Pgp1;CDW44;CSPG8;H-CAM;HCELL;ECM-III;HUTCH-1;HUTCH-I;ECMR-III;Hermes-1 | Full Name | CD44 molecule (Indian blood group) |
| Status | Confidence | Length | 93521 bases | Strand | Plus strand |
| Position | 11 : 35138882 - 35232402 | RNA binding domain | N.A. | ||
| Summary | The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008] | ||||
RNA binding domains (RBDs)
| Protein | Domain | Pfam ID | E-value | Domain number |
|---|
RNA binding proteomes (RBPomes)
| Pubmed ID | Full Name | Cell | Author | Time | Doi |
|---|
Literatures on RNA binding capacity
| Pubmed ID | Title | Author | Time | Journal |
|---|---|---|---|---|
| 25904917 | CD44 Acts as a Signaling Platform Controlling Tumor Progression and Metastasis. | Véronique Orian-Rousseau | 2015-01-01 | Frontiers in immunology |
| 30237756 | The Molecular Basis of Metastatic Colorectal Cancer. | F Sarah Andres | 2018-04-01 | Current colorectal cancer reports |
| 33143085 | Opposite Roles of Tra2β and SRSF9 in the v10 Exon Splicing of CD44. | Jagyeong Oh | 2020-10-30 | Cancers |
| 24840202 | Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing. | Yilin Xu | 2014-06-01 | Genes & development |
| 11447123 | The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4. | E Stickeler | 2001-07-16 | The EMBO journal |
| 37582871 | Identification of Significant RNA-Binding Proteins in the Process of CD44 Splicing Using the Boosted Beta Regression Algorithm. | O V Novosad | 2023-06-01 | Doklady. Biochemistry and biophysics |
| 37336810 | The RNA-Binding Proteins OAS1, ZFP36L2, and DHX58 Are Involved in the Regulation of CD44 mRNA Splicing in Colorectal Cancer Cells. | O V Novosad | 2023-05-01 | Bulletin of experimental biology and medicine |
| 31277295 | Metabolic Plasticity and Epithelial-Mesenchymal Transition. | M Timothy Thomson | 2019-07-03 | Journal of clinical medicine |
| 36750551 | RBM3 suppresses stemness remodeling of prostate cancer in bone microenvironment by modulating N6-methyladenosine on CTNNB1 mRNA. | Shouyi Zhang | 2023-02-07 | Cell death & disease |
| 28526879 | Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells. | Guang-Yuh Chiou | 2017-05-19 | Scientific reports |
| 33174000 | iTRAQ‑based proteomic analysis of the interaction of A549 human lung epithelial cells with Aspergillus fumigatus conidia. | Xiaowei Zhang | 2020-12-01 | Molecular medicine reports |
| 30059005 | An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer. | Ji Li | 2018-07-30 | eLife |
| 25184276 | NF-κB affects proliferation and invasiveness of breast cancer cells by regulating CD44 expression. | M Shannon Smith | 2014-01-01 | PloS one |
Transcripts
| Name | Transcript ID | bp | Protein | Translation ID |
|---|---|---|---|---|
| CD44-222 | ENST00000526025 | 1025 | 78aa | ENSP00000435377 |
| CD44-206 | ENST00000415148 | 2369 | 699aa | ENSP00000389830 |
| CD44-227 | ENST00000528086 | 580 | No protein | - |
| CD44-201 | ENST00000263398 | 4288 | 361aa | ENSP00000263398 |
| CD44-208 | ENST00000428726 | 5431 | 742aa | ENSP00000398632 |
| CD44-224 | ENST00000526669 | 870 | 206aa | ENSP00000432704 |
| CD44-207 | ENST00000425428 | 1768 | 80aa | ENSP00000395953 |
| CD44-209 | ENST00000433892 | 2292 | 493aa | ENSP00000392331 |
| CD44-214 | ENST00000525211 | 874 | 277aa | ENSP00000432405 |
| CD44-203 | ENST00000278386 | 484 | 139aa | ENSP00000278386 |
| CD44-210 | ENST00000434472 | 1634 | 429aa | ENSP00000404447 |
| CD44-205 | ENST00000352818 | 1023 | 340aa | ENSP00000309732 |
| CD44-211 | ENST00000442151 | 1825 | 294aa | ENSP00000398099 |
| CD44-221 | ENST00000526000 | 721 | 240aa | ENSP00000434465 |
| CD44-204 | ENST00000279452 | 862 | 287aa | ENSP00000279452 |
| CD44-226 | ENST00000527889 | 548 | 183aa | ENSP00000434530 |
| CD44-232 | ENST00000531118 | 877 | No protein | - |
| CD44-228 | ENST00000528455 | 687 | 229aa | ENSP00000432718 |
| CD44-234 | ENST00000531873 | 584 | 195aa | ENSP00000433189 |
| CD44-213 | ENST00000525209 | 574 | No protein | - |
| CD44-231 | ENST00000531110 | 806 | 268aa | ENSP00000436549 |
| CD44-219 | ENST00000525685 | 729 | 243aa | ENSP00000436623 |
| CD44-238 | ENST00000534296 | 863 | No protein | - |
| CD44-220 | ENST00000525688 | 560 | 186aa | ENSP00000436980 |
| CD44-202 | ENST00000278385 | 697 | 232aa | ENSP00000278385 |
| CD44-236 | ENST00000533222 | 581 | 193aa | ENSP00000435321 |
| CD44-215 | ENST00000525241 | 440 | No protein | - |
| CD44-212 | ENST00000524922 | 352 | 118aa | ENSP00000436451 |
| CD44-230 | ENST00000528922 | 1319 | No protein | - |
| CD44-217 | ENST00000525348 | 568 | No protein | - |
| CD44-223 | ENST00000526553 | 571 | 191aa | ENSP00000434418 |
| CD44-237 | ENST00000534082 | 564 | No protein | - |
| CD44-216 | ENST00000525293 | 569 | No protein | - |
| CD44-229 | ENST00000528672 | 586 | 195aa | ENSP00000431860 |
| CD44-235 | ENST00000532339 | 589 | No protein | - |
| CD44-225 | ENST00000527326 | 718 | No protein | - |
| CD44-233 | ENST00000531141 | 537 | No protein | - |
| CD44-218 | ENST00000525469 | 705 | 82aa | ENSP00000434920 |
GWAS
| ensgID | SNP | Chromosome | Position | Trait | PubmedID | Or or BEAT | EFO ID |
|---|
Protein-Protein Interaction (PPI)
Paralogs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Orthologs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Gene Ontology
| Go ID | Go term | No. evidence | Entries | Species | Category |
|---|---|---|---|---|---|
| GO:0004888 | enables transmembrane signaling receptor activity | 1 | IBA | Homo_sapiens(9606) | Function |
| GO:0004896 | contributes_to cytokine receptor activity | 2 | IBA,IDA | Homo_sapiens(9606) | Function |
| GO:0005515 | enables protein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0005518 | enables collagen binding | 1 | NAS | Homo_sapiens(9606) | Function |
| GO:0005540 | enables hyaluronic acid binding | 3 | IBA,IDA,NAS | Homo_sapiens(9606) | Function |
| GO:0005794 | located_in Golgi apparatus | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0005829 | located_in cytosol | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0005886 | is_active_in plasma membrane | 4 | IBA,IDA,NAS,TAS | Homo_sapiens(9606) | Component |
| GO:0005902 | located_in microvillus | 1 | ISS | Homo_sapiens(9606) | Component |
| GO:0005925 | located_in focal adhesion | 1 | HDA | Homo_sapiens(9606) | Component |
| GO:0006954 | involved_in inflammatory response | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0007155 | involved_in cell adhesion | 2 | IBA,IDA | Homo_sapiens(9606) | Process |
| GO:0007160 | involved_in cell-matrix adhesion | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:0009986 | located_in cell surface | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0016323 | is_active_in basolateral plasma membrane | 1 | IBA | Homo_sapiens(9606) | Component |
| GO:0016324 | located_in apical plasma membrane | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0016477 | involved_in cell migration | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0019221 | involved_in cytokine-mediated signaling pathway | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0030214 | involved_in hyaluronan catabolic process | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0030667 | located_in secretory granule membrane | 1 | TAS | Homo_sapiens(9606) | Component |
| GO:0031258 | located_in lamellipodium membrane | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0033138 | involved_in positive regulation of peptidyl-serine phosphorylation | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0034116 | involved_in positive regulation of heterotypic cell-cell adhesion | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0035692 | part_of macrophage migration inhibitory factor receptor complex | 2 | IBA,IDA | Homo_sapiens(9606) | Component |
| GO:0042110 | involved_in T cell activation | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0042995 | located_in cell projection | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0043066 | involved_in negative regulation of apoptotic process | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0043154 | involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0043518 | involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0044319 | involved_in wound healing, spreading of cells | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0044344 | involved_in cellular response to fibroblast growth factor stimulus | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0050731 | involved_in positive regulation of peptidyl-tyrosine phosphorylation | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0051216 | involved_in cartilage development | 1 | IEP | Homo_sapiens(9606) | Process |
| GO:0070062 | located_in extracellular exosome | 1 | HDA | Homo_sapiens(9606) | Component |
| GO:0070374 | involved_in positive regulation of ERK1 and ERK2 cascade | 2 | IBA,IDA | Homo_sapiens(9606) | Process |
| GO:0070487 | involved_in monocyte aggregation | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0098609 | involved_in cell-cell adhesion | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:1900625 | involved_in positive regulation of monocyte aggregation | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:1902166 | involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:2000392 | involved_in regulation of lamellipodium morphogenesis | 1 | IMP | Homo_sapiens(9606) | Process |