RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	SARS-COV-2
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000023318	Gene ID	23071	Accession	18311
Symbol	ERP44	Alias	PDIA10;TXNDC4	Full Name	endoplasmic reticulum protein 44
Status	Confidence	Length	119868 bases	Strand	Minus strand
Position	9 : 99979185 - 100099052	RNA binding domain	N.A.
Summary	This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
ERP44-201	ENST00000262455	4808	406aa	ENSP00000262455
ERP44-203	ENST00000685319	4785	No protein	-
ERP44-213	ENST00000690739	4538	344aa	ENSP00000508834
ERP44-208	ENST00000687093	4632	344aa	ENSP00000509315
ERP44-207	ENST00000687025	4652	57aa	ENSP00000510130
ERP44-214	ENST00000691188	4747	71aa	ENSP00000509263
ERP44-205	ENST00000686275	4441	105aa	ENSP00000510307
ERP44-215	ENST00000691823	5953	No protein	-
ERP44-212	ENST00000690317	4388	105aa	ENSP00000508466
ERP44-206	ENST00000687017	4592	256aa	ENSP00000508446
ERP44-210	ENST00000689406	4555	330aa	ENSP00000509116
ERP44-202	ENST00000684842	2287	98aa	ENSP00000509528
ERP44-209	ENST00000688230	2712	381aa	ENSP00000509300
ERP44-204	ENST00000685432	4084	No protein	-
ERP44-211	ENST00000690306	2728	No protein	-

Gene Model

Click here to download ENSG00000023318's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
29267	Cholesterol, HDL	7.9320000E-005	-
85529	Pre-Eclampsia	3E-6	23551011

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000023318's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003756	enables protein disulfide isomerase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005576	located_in extracellular region	1	TAS	Homo_sapiens(9606)	Component
GO:0005788	located_in endoplasmic reticulum lumen	1	IDA	Homo_sapiens(9606)	Component
GO:0005789	is_active_in endoplasmic reticulum membrane	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005793	is_active_in endoplasmic reticulum-Golgi intermediate compartment	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0006457	involved_in protein folding	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0006986	involved_in response to unfolded protein	1	IDA	Homo_sapiens(9606)	Process
GO:0009100	involved_in glycoprotein metabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0009986	located_in cell surface	1	IDA	Homo_sapiens(9606)	Component
GO:0034976	involved_in response to endoplasmic reticulum stress	1	IDA	Homo_sapiens(9606)	Process
GO:0035580	located_in specific granule lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0045454	involved_in cell redox homeostasis	1	TAS	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component

Expression