Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000020922 Gene ID 4361 Accession 7230
Symbol MRE11 Alias ATLD;HNGS1;MRE11A;MRE11B Full Name MRE11 homolog, double strand break repair nuclease
Status Confidence Length 78316 bases Strand Minus strand
Position 11 : 94415570 - 94493885 RNA binding domain N.A.
Summary This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
30594554 Proteomic analysis discovers the differential expression of novel proteins and phosphoproteins in meningioma including NEK9, HK2 and SET and deregulation of RNA metabolism. Jemma Dunn 2019-02-01 EBioMedicine
37035744 Dynamic of centromere associated RNAs and the centromere loading of DNA repair proteins in growing oocytes. Lin-Li Yang 2023-01-01 Frontiers in genetics
35453338 Metabolic Stress and Mitochondrial Dysfunction in Ataxia-Telangiectasia. Narayanan Goutham Subramanian 2022-03-28 Antioxidants (Basel, Switzerland)
29207607 Cyclin A2 regulates homologous recombination DNA repair and sensitivity to DNA damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors in human breast cancer cells. Wei Wei Gu 2017-10-31 Oncotarget
31000663 Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq. Beeke Wienert 2019-04-19 Science (New York, N.Y.)

Transcripts

Name Transcript ID bp Protein Translation ID
MRE11-201 ENST00000323929 6841 708aa ENSP00000325863
MRE11-204 ENST00000407439 2684 711aa ENSP00000385614
MRE11-202 ENST00000323977 2588 680aa ENSP00000326094
MRE11-203 ENST00000393241 2604 707aa ENSP00000376933
MRE11-205 ENST00000535120 234 No protein -
MRE11-209 ENST00000540013 1212 221aa ENSP00000440986
MRE11-210 ENST00000541157 594 No protein -
MRE11-207 ENST00000536754 572 127aa ENSP00000439511
MRE11-208 ENST00000538923 558 111aa ENSP00000442809
MRE11-206 ENST00000536144 619 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
11055Hip5.05582542858084E-717903296
11079Hip6.41468097372212E-717903296
11155Hip3.85985440793942E-617903296
36739Platelet Function Tests5.2600000E-006-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000020922

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000020922homo_sapiensENSP0000032586399.293898.8701nomascus_leucogenysENSNLEP0000003020899.293898.8701
ENSG00000020922homo_sapiensENSP0000032586394.632894.209pan_paniscusENSPPAP0000002338196.820896.3873
ENSG00000020922homo_sapiensENSP0000032586399.152598.8701pongo_abeliiENSPPYP0000004501699.152598.8701
ENSG00000020922homo_sapiensENSP0000032586398.728898.4463pan_troglodytesENSPTRP0000008845891.732391.4698
ENSG00000020922homo_sapiensENSP0000032586399.717599.7175gorilla_gorillaENSGGOP0000002110399.717599.7175
ENSG00000020922homo_sapiensENSP0000032586392.372985.5932ornithorhynchus_anatinusENSOANP0000001649192.503585.7143
ENSG00000020922homo_sapiensENSP0000032586393.502885.8757sarcophilus_harrisiiENSSHAP0000004443793.502885.8757
ENSG00000020922homo_sapiensENSP0000032586347.881444.4915notamacropus_eugeniiENSMEUP0000001376465.192360.5769
ENSG00000020922homo_sapiensENSP0000032586379.519877.2599choloepus_hoffmanniENSCHOP0000001040679.632277.3692
ENSG00000020922homo_sapiensENSP0000032586393.361687.9943dasypus_novemcinctusENSDNOP0000000065794.025688.6202
ENSG00000020922homo_sapiensENSP0000032586384.32281.3559erinaceus_europaeusENSEEUP0000000769791.006187.8049
ENSG00000020922homo_sapiensENSP0000032586375.847572.4576echinops_telfairiENSETEP0000001600181.610977.9635
ENSG00000020922homo_sapiensENSP0000032586397.316495.904callithrix_jacchusENSCJAP0000000736897.179195.7687
ENSG00000020922homo_sapiensENSP0000032586398.305197.8814cercocebus_atysENSCATP0000003638798.305197.8814
ENSG00000020922homo_sapiensENSP0000032586397.033995.339macaca_fascicularisENSMFAP0000005734569.817168.5976
ENSG00000020922homo_sapiensENSP0000032586397.033996.7514macaca_mulattaENSMMUP0000000550588.303388.0463
ENSG00000020922homo_sapiensENSP0000032586399.293899.0113macaca_nemestrinaENSMNEP0000001092199.293899.0113
ENSG00000020922homo_sapiensENSP0000032586397.033995.339papio_anubisENSPANP0000006051369.817168.5976
ENSG00000020922homo_sapiensENSP0000032586396.610296.1864mandrillus_leucophaeusENSMLEP0000000620999.130498.6957
ENSG00000020922homo_sapiensENSP0000032586394.77491.5254tursiops_truncatusENSTTRP0000001002094.908191.6549
ENSG00000020922homo_sapiensENSP0000032586396.892793.5028vulpes_vulpesENSVVUP0000001573396.892793.5028
ENSG00000020922homo_sapiensENSP0000032586393.361687.8531mus_spretusMGP_SPRETEiJ_P009030093.361687.8531
ENSG00000020922homo_sapiensENSP0000032586396.327792.0904equus_asinusENSEASP0000501750388.802184.8958
ENSG00000020922homo_sapiensENSP0000032586394.77491.2429capra_hircusENSCHIP0000002451692.679689.2265
ENSG00000020922homo_sapiensENSP0000032586393.644188.5593loxodonta_africanaENSLAFP0000001995493.51288.4344
ENSG00000020922homo_sapiensENSP0000032586395.621592.0904panthera_leoENSPLOP0000001549995.486691.9605
ENSG00000020922homo_sapiensENSP0000032586393.644190.3955ailuropoda_melanoleucaENSAMEP0000003914997.356893.9794
ENSG00000020922homo_sapiensENSP0000032586395.197790.678bos_indicus_hybridENSBIXP0000500986971.47468.0806
ENSG00000020922homo_sapiensENSP0000032586393.220389.8305oryctolagus_cuniculusENSOCUP0000001281297.058893.5294
ENSG00000020922homo_sapiensENSP0000032586395.90491.6667equus_caballusENSECAP0000006887588.411584.5052
ENSG00000020922homo_sapiensENSP0000032586397.175193.6441canis_lupus_familiarisENSCAFP0084502791097.175193.6441
ENSG00000020922homo_sapiensENSP0000032586395.621592.0904panthera_pardusENSPPRP0000001920595.486691.9605
ENSG00000020922homo_sapiensENSP0000032586396.468994.209marmota_marmota_marmotaENSMMMP0000000430896.742294.4759
ENSG00000020922homo_sapiensENSP0000032586395.33992.2316balaenoptera_musculusENSBMSP0001001108695.473892.3621
ENSG00000020922homo_sapiensENSP0000032586394.20990.2542cavia_porcellusENSCPOP0000001312294.475990.5099
ENSG00000020922homo_sapiensENSP0000032586396.045292.5141felis_catusENSFCAP0000002205792.140988.7534
ENSG00000020922homo_sapiensENSP0000032586397.033993.9266ursus_americanusENSUAMP0000002173897.033993.9266
ENSG00000020922homo_sapiensENSP0000032586393.502884.322monodelphis_domesticaENSMODP0000000027693.635184.4413
ENSG00000020922homo_sapiensENSP0000032586394.77491.3842bison_bison_bisonENSBBBP0000000494894.374190.9986
ENSG00000020922homo_sapiensENSP0000032586394.915391.2429monodon_monocerosENSMMNP0001502729295.049591.372
ENSG00000020922homo_sapiensENSP0000032586387.429482.2034sus_scrofaENSSSCP0000006756592.942987.3874
ENSG00000020922homo_sapiensENSP0000032586393.502890.5367microcebus_murinusENSMICP0000002976793.239490.2817
ENSG00000020922homo_sapiensENSP0000032586376.836274.8588microcebus_murinusENSMICP0000003487393.631791.222
ENSG00000020922homo_sapiensENSP0000032586391.525487.2881octodon_degusENSODEP0000002004693.237488.9209
ENSG00000020922homo_sapiensENSP0000032586394.067890.2542jaculus_jaculusENSJJAP0000000487094.334390.5099
ENSG00000020922homo_sapiensENSP0000032586394.632890.9604ovis_aries_rambouilletENSOARP0002001502394.766691.0891
ENSG00000020922homo_sapiensENSP0000032586397.033993.9266ursus_maritimusENSUMAP0000000937997.033993.9266
ENSG00000020922homo_sapiensENSP0000032586354.66151.5537ochotona_princepsENSOPRP0000000387554.583951.481
ENSG00000020922homo_sapiensENSP0000032586394.491590.678delphinapterus_leucasENSDLEP0000001194393.828990.0421
ENSG00000020922homo_sapiensENSP0000032586395.056591.5254physeter_catodonENSPCTP0000500620395.190991.6549
ENSG00000020922homo_sapiensENSP0000032586393.361688.5593mus_caroliMGP_CAROLIEiJ_P008675693.626188.8102
ENSG00000020922homo_sapiensENSP0000032586393.502887.9943mus_musculusENSMUSP0000003440593.767788.2436
ENSG00000020922homo_sapiensENSP0000032586328.107327.8249dipodomys_ordiiENSDORP0000000451798.029697.0443
ENSG00000020922homo_sapiensENSP0000032586396.045291.9492mustela_putorius_furoENSMPUP0000001215396.18192.0792
ENSG00000020922homo_sapiensENSP0000032586384.180881.6384aotus_nancymaaeENSANAP0000000447592.834990.0312
ENSG00000020922homo_sapiensENSP0000032586396.892795.6215saimiri_boliviensis_boliviensisENSSBOP0000000388496.75695.4866
ENSG00000020922homo_sapiensENSP0000032586377.259974.0113vicugna_pacosENSVPAP0000000542077.478874.221
ENSG00000020922homo_sapiensENSP0000032586399.43598.8701chlorocebus_sabaeusENSCSAP0000001466299.43598.8701
ENSG00000020922homo_sapiensENSP0000032586360.734559.0395tupaia_belangeriENSTBEP0000000286866.978265.109
ENSG00000020922homo_sapiensENSP0000032586327.966126.9774mesocricetus_auratusENSMAUP0000001739997.536994.0887
ENSG00000020922homo_sapiensENSP0000032586389.406886.1582phocoena_sinusENSPSNP0000001771095.909192.4242
ENSG00000020922homo_sapiensENSP0000032586395.33991.2429camelus_dromedariusENSCDRP0000502207194.936790.8579
ENSG00000020922homo_sapiensENSP0000032586394.77491.5254carlito_syrichtaENSTSYP0000002008795.994392.7039
ENSG00000020922homo_sapiensENSP0000032586396.186492.6554panthera_tigris_altaicaENSPTIP0000002443596.050892.5247
ENSG00000020922homo_sapiensENSP0000032586393.644188.4181rattus_norvegicusENSRNOP0000008678693.909388.6686
ENSG00000020922homo_sapiensENSP0000032586392.372990.113prolemur_simusENSPSMP0000003074693.162490.8832
ENSG00000020922homo_sapiensENSP0000032586328.107327.2599microtus_ochrogasterENSMOCP0000001120398.029695.0739
ENSG00000020922homo_sapiensENSP0000032586388.135683.6158sorex_araneusENSSARP0000000391288.888984.3305
ENSG00000020922homo_sapiensENSP0000032586393.926689.548peromyscus_maniculatus_bairdiiENSPEMP0000002744693.926689.548
ENSG00000020922homo_sapiensENSP0000032586395.480292.2316bos_mutusENSBMUP0000000575095.480292.2316
ENSG00000020922homo_sapiensENSP0000032586393.644188.5593mus_spicilegusENSMSIP0000001957988.483.6
ENSG00000020922homo_sapiensENSP0000032586395.056589.8305cricetulus_griseus_chok1gshdENSCGRP0000100507395.46190.2128
ENSG00000020922homo_sapiensENSP0000032586343.926641.8079pteropus_vampyrusENSPVAP0000000886874.759671.1538
ENSG00000020922homo_sapiensENSP0000032586395.90490.3955myotis_lucifugusENSMLUP0000000183095.09889.6359
ENSG00000020922homo_sapiensENSP0000032586394.067885.452vombatus_ursinusENSVURP0001001368294.067885.452
ENSG00000020922homo_sapiensENSP0000032586395.056591.2429rhinolophus_ferrumequinumENSRFEP0001003064794.922491.1142
ENSG00000020922homo_sapiensENSP0000032586392.231687.7119neovison_visonENSNVIP0000000694293.285788.7143
ENSG00000020922homo_sapiensENSP0000032586395.480292.0904bos_taurusENSBTAP0000001174895.480292.0904
ENSG00000020922homo_sapiensENSP0000032586396.186491.9492heterocephalus_glaber_femaleENSHGLP0000002208196.186491.9492
ENSG00000020922homo_sapiensENSP0000032586392.231691.8079rhinopithecus_bietiENSRBIP0000002147297.90197.4513
ENSG00000020922homo_sapiensENSP0000032586397.175193.6441canis_lupus_dingoENSCAFP0002002090097.175193.6441
ENSG00000020922homo_sapiensENSP0000032586394.067891.5254sciurus_vulgarisENSSVLP0000501184798.085495.4345
ENSG00000020922homo_sapiensENSP0000032586391.384283.1921phascolarctos_cinereusENSPCIP0000004942793.904285.4862
ENSG00000020922homo_sapiensENSP0000032586392.090488.2768procavia_capensisENSPCAP0000001429594.492890.5797
ENSG00000020922homo_sapiensENSP0000032586394.20987.8531nannospalax_galiliENSNGAP0000000707994.342387.9774
ENSG00000020922homo_sapiensENSP0000032586394.77491.3842bos_grunniensENSBGRP0000003452194.374190.9986
ENSG00000020922homo_sapiensENSP0000032586392.372987.2881chinchilla_lanigeraENSCLAP0000000087694.100788.9209
ENSG00000020922homo_sapiensENSP0000032586320.33918.0791chinchilla_lanigeraENSCLAP0000001951584.705975.2941
ENSG00000020922homo_sapiensENSP0000032586394.20991.1017cervus_hanglu_yarkandensisENSCHYP0000000002893.811590.7173
ENSG00000020922homo_sapiensENSP0000032586392.231686.7232catagonus_wagneriENSCWAP0000000253395.888490.1615
ENSG00000020922homo_sapiensENSP0000032586396.327793.6441ictidomys_tridecemlineatusENSSTOP0000002445296.463993.7765
ENSG00000020922homo_sapiensENSP0000032586396.045293.0791otolemur_garnettiiENSOGAP0000001087495.505692.5562
ENSG00000020922homo_sapiensENSP0000032586396.892795.4802cebus_imitatorENSCCAP0000000228596.75695.3456
ENSG00000020922homo_sapiensENSP0000032586396.045293.3616urocitellus_parryiiENSUPAP0001000219896.18193.4936
ENSG00000020922homo_sapiensENSP0000032586393.926690.678moschus_moschiferusENSMMSP0000001256193.530290.2954
ENSG00000020922homo_sapiensENSP0000032586313.983113.2768moschus_moschiferusENSMMSP0000001636986.842182.4561
ENSG00000020922homo_sapiensENSP0000032586399.293899.0113rhinopithecus_roxellanaENSRROP0000003412299.293899.0113
ENSG00000020922homo_sapiensENSP0000032586390.254285.3107mus_pahariMGP_PahariEiJ_P002241894.10988.9543
ENSG00000020922homo_sapiensENSP0000032586396.610294.209propithecus_coquereliENSPCOP0000000858996.473994.0762
ENSG00000020922homo_sapiensENSP0000032586349.43532.7684caenorhabditis_elegansZC302.1.248.076931.8681
ENSG00000020922homo_sapiensENSP0000032586350.423734.887drosophila_melanogasterFBpp007980257.580639.8387
ENSG00000020922homo_sapiensENSP0000032586354.09637.4294ciona_intestinalisENSCINP0000001028372.264250
ENSG00000020922homo_sapiensENSP0000032586345.33933.3333petromyzon_marinusENSPMAP0000000728266.459648.8613
ENSG00000020922homo_sapiensENSP0000032586357.344641.9492eptatretus_burgeriENSEBUP0000000477473.952654.0984
ENSG00000020922homo_sapiensENSP0000032586384.32270.4802callorhinchus_miliiENSCMIP0000003000883.03269.4019
ENSG00000020922homo_sapiensENSP0000032586386.440774.435latimeria_chalumnaeENSLACP0000000461886.197274.2253
ENSG00000020922homo_sapiensENSP0000032586383.192167.5141lepisosteus_oculatusENSLOCP0000000912581.241465.931
ENSG00000020922homo_sapiensENSP0000032586322.033915.678clupea_harengusENSCHAP0000003816779.591856.6327
ENSG00000020922homo_sapiensENSP0000032586379.943563.4181danio_rerioENSDARP0000013943780.857164.1429
ENSG00000020922homo_sapiensENSP0000032586379.802363.5593carassius_auratusENSCARP0000010636580.829864.3777
ENSG00000020922homo_sapiensENSP0000032586380.932263.2768astyanax_mexicanusENSAMXP0000003504180.818163.1876
ENSG00000020922homo_sapiensENSP0000032586378.389862.1469ictalurus_punctatusENSIPUP0000000166879.512963.0373
ENSG00000020922homo_sapiensENSP0000032586377.966162.2881esox_luciusENSELUP0000001004678.632562.8205
ENSG00000020922homo_sapiensENSP0000032586372.457657.6271electrophorus_electricusENSEEEP0000002486076.911561.1694
ENSG00000020922homo_sapiensENSP0000032586378.813662.4294oncorhynchus_kisutchENSOKIP0000504088171.082856.3057
ENSG00000020922homo_sapiensENSP0000032586372.457657.9096oncorhynchus_mykissENSOMYP0000012073880.660464.4654
ENSG00000020922homo_sapiensENSP0000032586378.954862.8531salmo_salarENSSSAP0000014148178.511262.5
ENSG00000020922homo_sapiensENSP0000032586378.813662.4294salmo_truttaENSSTUP0000006924279.374162.8734
ENSG00000020922homo_sapiensENSP0000032586365.395552.9661gadus_morhuaENSGMOP0000004826056.670745.8996
ENSG00000020922homo_sapiensENSP0000032586375.988761.0169fundulus_heteroclitusENSFHEP0000002499777.633562.3377
ENSG00000020922homo_sapiensENSP0000032586368.644156.9209poecilia_reticulataENSPREP0000003350979.541765.9574
ENSG00000020922homo_sapiensENSP0000032586375.282560.1695xiphophorus_maculatusENSXMAP0000000401471.736257.3351
ENSG00000020922homo_sapiensENSP0000032586375.282560.452oryzias_latipesENSORLP0000000910676.801261.6715
ENSG00000020922homo_sapiensENSP0000032586375.423759.887cyclopterus_lumpusENSCLMP0000502334777.279361.3603
ENSG00000020922homo_sapiensENSP0000032586374.576361.5819oreochromis_niloticusENSONIP0000004799275.644762.4642
ENSG00000020922homo_sapiensENSP0000032586374.43561.1582haplochromis_burtoniENSHBUP0000003228775.827362.3022
ENSG00000020922homo_sapiensENSP0000032586373.446359.6045astatotilapia_callipteraENSACLP0000002713073.550259.6888
ENSG00000020922homo_sapiensENSP0000032586376.412459.887sparus_aurataENSSAUP0001003488278.066461.1833
ENSG00000020922homo_sapiensENSP0000032586373.022657.7684lates_calcariferENSLCAP0001003535977.627661.4114
ENSG00000020922homo_sapiensENSP0000032586384.88773.1638xenopus_tropicalisENSXETP0000006197284.767373.0606
ENSG00000020922homo_sapiensENSP0000032586377.966169.9153chrysemys_picta_belliiENSCPBP0000003444885.847676.9829
ENSG00000020922homo_sapiensENSP0000032586329.66127.6836sphenodon_punctatusENSSPUP0000000544595.890489.4977
ENSG00000020922homo_sapiensENSP000003258637.344636.07345sphenodon_punctatusENSSPUP0000001209594.545578.1818
ENSG00000020922homo_sapiensENSP0000032586386.440776.5537crocodylus_porosusENSCPRP0000502191986.07676.2307
ENSG00000020922homo_sapiensENSP0000032586385.45272.8814laticauda_laticaudataENSLLTP0000000590886.552273.8197
ENSG00000020922homo_sapiensENSP0000032586330.508527.2599notechis_scutatusENSNSUP0000002495292.703982.8326
ENSG00000020922homo_sapiensENSP0000032586367.514159.1808pseudonaja_textilisENSPTXP0000000653287.867677.0221
ENSG00000020922homo_sapiensENSP0000032586329.378526.1299anas_platyrhynchos_platyrhynchosENSAPLP0000002186990.434880.4348
ENSG00000020922homo_sapiensENSP0000032586385.028373.5876gallus_gallusENSGALP000100118218674.4286
ENSG00000020922homo_sapiensENSP0000032586384.604572.3164serinus_canariaENSSCAP0000000448385.327672.9345
ENSG00000020922homo_sapiensENSP0000032586384.463373.1638parus_majorENSPMJP0000002428985.306773.8944
ENSG00000020922homo_sapiensENSP0000032586380.649771.1864anolis_carolinensisENSACAP0000003952785.223975.2239
ENSG00000020922homo_sapiensENSP0000032586368.361657.2034neolamprologus_brichardiENSNBRP0000000869779.344366.3934
ENSG00000020922homo_sapiensENSP0000032586325.706222.4576naja_najaENSNNAP0000000595989.215777.9412
ENSG00000020922homo_sapiensENSP0000032586351.836243.9266naja_najaENSNNAP0000000598183.409170.6818
ENSG00000020922homo_sapiensENSP0000032586386.299476.9774podarcis_muralisENSPMRP0000001263885.814676.5449
ENSG00000020922homo_sapiensENSP0000032586385.169572.4576geospiza_fortisENSGFOP0000000609785.653472.8693
ENSG00000020922homo_sapiensENSP0000032586384.180871.7514taeniopygia_guttataENSTGUP0000001320683.240270.9497
ENSG00000020922homo_sapiensENSP0000032586383.757170.339erpetoichthys_calabaricusENSECRP0000000287981.906168.7845
ENSG00000020922homo_sapiensENSP0000032586375.423760.452kryptolebias_marmoratusENSKMAP0000001207176.724161.4943
ENSG00000020922homo_sapiensENSP0000032586385.45275.2825salvator_merianaeENSSMRP0000001265787.427777.0231
ENSG00000020922homo_sapiensENSP0000032586373.022658.3333oryzias_javanicusENSOJAP0000003544772.005657.5209
ENSG00000020922homo_sapiensENSP0000032586368.079156.7797amphilophus_citrinellusENSACIP0000000109879.933766.6667
ENSG00000020922homo_sapiensENSP0000032586376.129960.3107dicentrarchus_labraxENSDLAP0000503207077.220661.1748
ENSG00000020922homo_sapiensENSP0000032586375.988761.2994amphiprion_perculaENSAPEP0000001674576.529261.7354
ENSG00000020922homo_sapiensENSP0000032586375.282560.452oryzias_sinensisENSOSIP0000004340676.801261.6715
ENSG00000020922homo_sapiensENSP0000032586387.288177.4011pelodiscus_sinensisENSPSIP0000000652486.554676.7507
ENSG00000020922homo_sapiensENSP0000032586387.288178.1073gopherus_evgoodeiENSGEVP0000500824786.919877.7778
ENSG00000020922homo_sapiensENSP0000032586368.785360.3107chelonoidis_abingdoniiENSCABP0000000179878.170168.5393
ENSG00000020922homo_sapiensENSP0000032586376.694960.1695seriola_dumeriliENSSDUP0000002972778.017261.2069
ENSG00000020922homo_sapiensENSP0000032586376.694960.1695cottoperca_gobioENSCGOP0000001497576.157159.7475
ENSG00000020922homo_sapiensENSP0000032586377.401168.5028struthio_camelus_australisENSSCUP0000000572187.261177.2293
ENSG00000020922homo_sapiensENSP0000032586385.169573.8701anser_brachyrhynchusENSABRP0000002733285.775274.3954
ENSG00000020922homo_sapiensENSP0000032586375.423760.7345gasterosteus_aculeatusENSGACP0000001232075.744760.9929
ENSG00000020922homo_sapiensENSP0000032586374.293859.322cynoglossus_semilaevisENSCSEP0000002630273.259158.4958
ENSG00000020922homo_sapiensENSP0000032586375.706261.0169poecilia_formosaENSPFOP0000000327574.238259.8338
ENSG00000020922homo_sapiensENSP0000032586376.553761.4407sander_luciopercaENSSLUP0000003708878.210762.7706
ENSG00000020922homo_sapiensENSP0000032586384.039673.3051strigops_habroptilaENSSHBP0000500372984.397273.617
ENSG00000020922homo_sapiensENSP0000032586375.847561.1582amphiprion_ocellarisENSAOCP0000003211977.044562.1234
ENSG00000020922homo_sapiensENSP0000032586328.248626.8362terrapene_carolina_triunguisENSTMTP0000002846894.339689.6226
ENSG00000020922homo_sapiensENSP0000032586341.949237.0056terrapene_carolina_triunguisENSTMTP0000002845582.572.7778
ENSG00000020922homo_sapiensENSP0000032586378.389862.2881hucho_huchoENSHHUP0000002641375.203359.7561
ENSG00000020922homo_sapiensENSP0000032586376.553760.0282betta_splendensENSBSLP0000002495874.861958.7017
ENSG00000020922homo_sapiensENSP0000032586376.129960.8757anabas_testudineusENSATEP0000001740977.55462.0144
ENSG00000020922homo_sapiensENSP0000032586323.163817.0904ciona_savignyiENSCSAVP0000000743177.725157.346
ENSG00000020922homo_sapiensENSP0000032586350.706234.0395saccharomyces_cerevisiaeYMR224C51.878634.8266
ENSG00000020922homo_sapiensENSP0000032586369.77455.5085seriola_lalandi_dorsalisENSSLDP0000002814575.190359.8174
ENSG00000020922homo_sapiensENSP0000032586370.056556.4972labrus_bergyltaENSLBEP0000003417377.379162.4025
ENSG00000020922homo_sapiensENSP0000032586375.423761.8644pundamilia_nyerereiENSPNYP0000002422277.503663.5704
ENSG00000020922homo_sapiensENSP0000032586375.847561.2994mastacembelus_armatusENSMAMP0000001551376.934162.1777
ENSG00000020922homo_sapiensENSP0000032586376.271261.0169stegastes_partitusENSSPAP0000000386977.363961.8911
ENSG00000020922homo_sapiensENSP0000032586372.033957.0621acanthochromis_polyacanthusENSAPOP0000003270075.892960.119
ENSG00000020922homo_sapiensENSP0000032586385.875773.7288aquila_chrysaetos_chrysaetosENSACCP0002001339986.11973.9377
ENSG00000020922homo_sapiensENSP0000032586375.847559.887nothobranchius_furzeriENSNFUP0001503243178.052361.6279
ENSG00000020922homo_sapiensENSP0000032586375.988760.7345cyprinodon_variegatusENSCVAP0000002959777.745762.1387
ENSG00000020922homo_sapiensENSP0000032586376.553759.4633denticeps_clupeoidesENSDCDP0000002699078.893761.2809
ENSG00000020922homo_sapiensENSP0000032586375.847559.1808larimichthys_croceaENSLCRP0000503301076.82459.9428
ENSG00000020922homo_sapiensENSP0000032586373.728858.6158takifugu_rubripesENSTRUP0000003454775.542760.0579
ENSG00000020922homo_sapiensENSP0000032586383.474671.8927ficedula_albicollisENSFALP0000000032284.670572.9226
ENSG00000020922homo_sapiensENSP0000032586375.706258.7571hippocampus_comesENSHCOP0000000487772.628756.3686
ENSG00000020922homo_sapiensENSP0000032586379.519863.2768cyprinus_carpio_carpioENSCCRP0000017261478.631362.5698
ENSG00000020922homo_sapiensENSP0000032586383.898372.4576coturnix_japonicaENSCJPP0000500386584.857173.2857
ENSG00000020922homo_sapiensENSP0000032586375.706261.0169poecilia_latipinnaENSPLAP0000000650377.681262.6087
ENSG00000020922homo_sapiensENSP0000032586375.141259.4633sinocyclocheilus_grahamiENSSGRP0000005121774.19858.7169
ENSG00000020922homo_sapiensENSP0000032586368.644157.3446maylandia_zebraENSMZEP0000503773779.934266.7763
ENSG00000020922homo_sapiensENSP0000032586372.033959.4633maylandia_zebraENSMZEP0000502154277.507663.9818
ENSG00000020922homo_sapiensENSP0000032586372.033957.0621tetraodon_nigroviridisENSTNIP0000000173576.00660.2086
ENSG00000020922homo_sapiensENSP0000032586380.649765.3955paramormyrops_kingsleyaeENSPKIP0000000582580.084264.9369
ENSG00000020922homo_sapiensENSP0000032586382.344664.9717scleropages_formosusENSSFOP0001502445281.88264.6067
ENSG00000020922homo_sapiensENSP0000032586384.32271.7514leptobrachium_leishanenseENSLLEP0000000114877.131865.6331
ENSG00000020922homo_sapiensENSP0000032586376.553760.5932scophthalmus_maximusENSSMAP0000004131471.978856.9721
ENSG00000020922homo_sapiensENSP0000032586375.706260.7345oryzias_melastigmaENSOMEP0000003037577.568762.2287

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000014enables single-stranded DNA endodeoxyribonuclease activity2IBA,IDAHomo_sapiens(9606)Function
GO:0000019involved_in regulation of mitotic recombination1TASHomo_sapiens(9606)Process
GO:0000723involved_in telomere maintenance1IBAHomo_sapiens(9606)Process
GO:0000724involved_in double-strand break repair via homologous recombination2IBA,IDAHomo_sapiens(9606)Process
GO:0000729involved_in DNA double-strand break processing2NAS,TASHomo_sapiens(9606)Process
GO:0000781located_in chromosome, telomeric region4HDA,IDA,ISSHomo_sapiens(9606)Component
GO:0003677contributes_to DNA binding1IDAHomo_sapiens(9606)Function
GO:0003678contributes_to DNA helicase activity1IMPHomo_sapiens(9606)Function
GO:0003690enables double-stranded DNA binding1TASHomo_sapiens(9606)Function
GO:0004518enables nuclease activity1TASHomo_sapiens(9606)Function
GO:0004520enables DNA endonuclease activity2IDA,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1NASHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005657located_in replication fork1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006281involved_in DNA repair1TASHomo_sapiens(9606)Process
GO:0006302involved_in double-strand break repair1TASHomo_sapiens(9606)Process
GO:0006303involved_in double-strand break repair via nonhomologous end joining2IBA,IDAHomo_sapiens(9606)Process
GO:0006310involved_in DNA recombination1TASHomo_sapiens(9606)Process
GO:0006974acts_upstream_of_or_within DNA damage response2IDAHomo_sapiens(9606)Process
GO:0007004involved_in telomere maintenance via telomerase1TASHomo_sapiens(9606)Process
GO:0007062involved_in sister chromatid cohesion1IMPHomo_sapiens(9606)Process
GO:0007095involved_in mitotic G2 DNA damage checkpoint signaling1IBAHomo_sapiens(9606)Process
GO:0007129involved_in homologous chromosome pairing at meiosis1IEAHomo_sapiens(9606)Process
GO:0007131involved_in reciprocal meiotic recombination1TASHomo_sapiens(9606)Process
GO:0008283involved_in cell population proliferation1IEAHomo_sapiens(9606)Process
GO:0008296enables 3-5-DNA exonuclease activity1IEAHomo_sapiens(9606)Function
GO:0008408enables 3-5 exonuclease activity1IDAHomo_sapiens(9606)Function
GO:0008409enables 5-3 exonuclease activity1IDAHomo_sapiens(9606)Function
GO:0016605located_in PML body2IDA,ISSHomo_sapiens(9606)Component
GO:0030145enables manganese ion binding1IEAHomo_sapiens(9606)Function
GO:0030870part_of Mre11 complex5IBA,IDA,IPI,NAS,TASHomo_sapiens(9606)Component
GO:0031573involved_in mitotic intra-S DNA damage checkpoint signaling1IBAHomo_sapiens(9606)Process
GO:0031860involved_in telomeric 3 overhang formation1IMPHomo_sapiens(9606)Process
GO:0031954involved_in positive regulation of protein autophosphorylation1IDAHomo_sapiens(9606)Process
GO:0032206involved_in positive regulation of telomere maintenance1IMPHomo_sapiens(9606)Process
GO:0032508involved_in DNA duplex unwinding1IMPHomo_sapiens(9606)Process
GO:0033674involved_in positive regulation of kinase activity1IDAHomo_sapiens(9606)Process
GO:0035825involved_in homologous recombination1NASHomo_sapiens(9606)Process
GO:0035861is_active_in site of double-strand break2IBA,IDAHomo_sapiens(9606)Component
GO:0042138involved_in meiotic DNA double-strand break formation1IBAHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0043066involved_in negative regulation of apoptotic process1IMPHomo_sapiens(9606)Process
GO:0044818involved_in mitotic G2/M transition checkpoint1NASHomo_sapiens(9606)Process
GO:0045296enables cadherin binding1HDAHomo_sapiens(9606)Function
GO:0070533part_of BRCA1-C complex1IPIHomo_sapiens(9606)Component
GO:0097552involved_in mitochondrial double-strand break repair via homologous recombination1IBAHomo_sapiens(9606)Process
GO:0098687located_in chromosomal region1NASHomo_sapiens(9606)Component
GO:0110025involved_in DNA strand resection involved in replication fork processing2IDA,NASHomo_sapiens(9606)Process

Expression