RBPWorld - a comprehensive database of RNA Binding Proteins

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RBP World!

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000013523	Gene ID	23357	Accession	19961
Symbol	ANGEL1	Alias	Ccr4e;KIAA0759	Full Name	angel homolog 1
Status	Confidence	Length	40238 bases	Strand	Minus strand
Position	14 : 76786009 - 76826246	RNA binding domain	Exo_endo_phos
Summary	Enables eukaryotic initiation factor 4E binding activity and protein domain specific binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, exonucleolytic. Located in several cellular components, including cis-Golgi network; endoplasmic reticulum; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000251089	Exo_endo_phos	PF03372	2.5e-45	1
ENSP00000451534	Exo_endo_phos	PF03372	1.7e-06	1

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
ANGEL1-201	ENST00000251089	5287	670aa	ENSP00000251089
ANGEL1-205	ENST00000557179	1427	235aa	ENSP00000451534
ANGEL1-203	ENST00000555079	553	67aa	ENSP00000452287
ANGEL1-204	ENST00000556298	727	129aa	ENSP00000451568
ANGEL1-202	ENST00000554941	694	No protein	-
ANGEL1-206	ENST00000557497	577	131aa	ENSP00000498076

Gene Model

Click here to download ENSG00000013523's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
6449	Fibrinogen	6.22803643169883E-5	17903294
6465	Fibrinogen	1.73907581706195E-5	17903294

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000013523's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000175	enables 3-5-RNA exonuclease activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005783	located_in endoplasmic reticulum	1	IDA	Homo_sapiens(9606)	Component
GO:0005801	located_in cis-Golgi network	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0008190	enables eukaryotic initiation factor 4E binding	1	IDA	Homo_sapiens(9606)	Function
GO:0019904	enables protein domain specific binding	1	IDA	Homo_sapiens(9606)	Function
GO:0048471	located_in perinuclear region of cytoplasm	1	IDA	Homo_sapiens(9606)	Component

Expression