RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000011485	Gene ID	5536	Accession	9322
Symbol	PPP5C	Alias	PP5;PPT;PPP5	Full Name	protein phosphatase 5 catalytic subunit
Status	Confidence	Length	45895 bases	Strand	Plus strand
Position	19 : 46347087 - 46392981	RNA binding domain	N.A.
Summary	This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
PPP5C-201	ENST00000012443	2139	499aa	ENSP00000012443
PPP5C-205	ENST00000478046	1886	485aa	ENSP00000434329
PPP5C-202	ENST00000391919	1929	371aa	ENSP00000375786
PPP5C-204	ENST00000467902	399	No protein	-
PPP5C-212	ENST00000527193	548	No protein	-
PPP5C-207	ENST00000487483	4675	No protein	-
PPP5C-214	ENST00000532058	1970	No protein	-
PPP5C-206	ENST00000486994	2209	No protein	-
PPP5C-203	ENST00000467502	1235	No protein	-
PPP5C-210	ENST00000493347	431	No protein	-
PPP5C-215	ENST00000595055	556	No protein	-
PPP5C-208	ENST00000491003	878	No protein	-
PPP5C-209	ENST00000492109	848	No protein	-
PPP5C-211	ENST00000525507	1300	No protein	-
PPP5C-213	ENST00000527623	1215	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
61721	Crohn Disease	9E-12	26192919
62824	Inflammatory Bowel Diseases	2E-8	26192919
64520	Crohn Disease	4E-7	28067908
96826	Crohn Disease	2E-10	23128233

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000165	involved_in MAPK cascade	1	TAS	Homo_sapiens(9606)	Process
GO:0000278	involved_in mitotic cell cycle	1	TAS	Homo_sapiens(9606)	Process
GO:0003723	enables RNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0004721	enables phosphoprotein phosphatase activity	2	ISS,TAS	Homo_sapiens(9606)	Function
GO:0004722	enables protein serine/threonine phosphatase activity	4	IBA,IDA,ISS,TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005829	is_active_in cytosol	3	IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0005886	located_in plasma membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0006302	involved_in double-strand break repair	1	TAS	Homo_sapiens(9606)	Process
GO:0006351	involved_in DNA-templated transcription	1	TAS	Homo_sapiens(9606)	Process
GO:0006470	involved_in protein dephosphorylation	1	TAS	Homo_sapiens(9606)	Process
GO:0008289	enables lipid binding	1	IEA	Homo_sapiens(9606)	Function
GO:0010288	involved_in response to lead ion	1	ISS	Homo_sapiens(9606)	Process
GO:0016791	enables phosphatase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0017018	enables myosin phosphatase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0032991	part_of protein-containing complex	1	IDA	Homo_sapiens(9606)	Component
GO:0035970	involved_in peptidyl-threonine dephosphorylation	1	TAS	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0043123	involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling	1	HMP	Homo_sapiens(9606)	Process
GO:0043231	located_in intracellular membrane-bounded organelle	1	IDA	Homo_sapiens(9606)	Component
GO:0043278	involved_in response to morphine	1	IEA	Homo_sapiens(9606)	Process
GO:0043531	enables ADP binding	1	IDA	Homo_sapiens(9606)	Function
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0048156	enables tau protein binding	1	NAS	Homo_sapiens(9606)	Function
GO:0051879	enables Hsp90 protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0060090	enables molecular adaptor activity	1	EXP	Homo_sapiens(9606)	Function
GO:0070262	involved_in peptidyl-serine dephosphorylation	2	IDA,TAS	Homo_sapiens(9606)	Process
GO:0101031	part_of protein folding chaperone complex	1	IDA	Homo_sapiens(9606)	Component
GO:1904550	involved_in response to arachidonic acid	1	ISS	Homo_sapiens(9606)	Process