Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000011465 Gene ID 1634 Accession 2705
Symbol DCN Alias CSCD;PG40;PGII;PGS2;DSPG2;SLRR1B Full Name decorin
Status Confidence Length 42734 bases Strand Minus strand
Position 12 : 91140484 - 91183217 RNA binding domain N.A.
Summary This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
27651452 BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire. Zeynab Najafova 2017-01-09 Nucleic acids research

Transcripts

Name Transcript ID bp Protein Translation ID
DCN-201 ENST00000052754 6850 359aa ENSP00000052754
DCN-204 ENST00000425043 1438 212aa ENSP00000401021
DCN-202 ENST00000393155 2344 77aa ENSP00000376862
DCN-212 ENST00000548218 356 52aa ENSP00000448853
DCN-220 ENST00000552962 1930 359aa ENSP00000447654
DCN-203 ENST00000420120 753 250aa ENSP00000413723
DCN-205 ENST00000441303 519 172aa ENSP00000399815
DCN-210 ENST00000547568 823 212aa ENSP00000447674
DCN-208 ENST00000546391 716 177aa ENSP00000446530
DCN-206 ENST00000456569 228 75aa ENSP00000398514
DCN-217 ENST00000550758 1064 95aa ENSP00000449408
DCN-211 ENST00000547937 750 179aa ENSP00000449782
DCN-219 ENST00000552145 648 178aa ENSP00000447886
DCN-216 ENST00000550563 593 174aa ENSP00000449014
DCN-214 ENST00000549513 920 119aa ENSP00000449438
DCN-207 ENST00000546370 586 88aa ENSP00000446527
DCN-209 ENST00000546745 1026 98aa ENSP00000448857
DCN-215 ENST00000550099 719 98aa ENSP00000448057
DCN-218 ENST00000551354 2924 100aa ENSP00000448274
DCN-213 ENST00000548768 568 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
1004Body Height3.50346371375806E-517903300
4315Cholesterol, LDL9.25427082885242E-717903299
4354Cholesterol, LDL3.15830211526195E-717903299
14681Alzheimer Disease1.8157841E-00417998437
16725Alcoholism4.44E-05-
16728Alcoholism6.57E-05-
16753Alcoholism6.02E-05-
19234Heart Rate3.475e-005-
19236Heart Rate3.705e-005-
19237Heart Rate3.475e-005-
19246Heart Rate3.475e-005-
19251Heart Rate3.999e-005-
19252Heart Rate3.773e-005-
19253Heart Rate3.773e-005-
28372Nutritional and Metabolic Diseases2.4980000E-005-
35225Platelet Function Tests7.2900000E-006-
35293Platelet Function Tests9.4300000E-006-
38499Platelet Function Tests4.4400000E-016-
38577Platelet Function Tests4.4400000E-016-
40508Platelet Function Tests2.6841100E-005-
46827Platelet Function Tests1.0060000E-005-
48067Autistic Disorder1.4034000E-005-
48071Autistic Disorder3.5689000E-005-
48072Autistic Disorder3.2915000E-005-
48823Autistic Disorder2.3119000E-006-
48827Autistic Disorder1.2174000E-005-
48828Autistic Disorder4.9143000E-006-
48829Autistic Disorder4.1161000E-006-
51001Autistic Disorder1.9910000E-005-
52888Interleukin-184.4680000E-005-
61627Education4E-827225129
70954Antibodies4E-624324551
70955Trypanosoma cruzi4E-624324551
71063Bronchodilator Agents3E-626634245
71064Lung Volume Measurements3E-626634245
73577Schizophrenia2E-726198764
77327Education5E-927225129
78947Cholesterol5E-619260141
83477Death, Sudden, Cardiac5E-621658281
83508Bronchodilator Agents2E-626634245
83509Forced Expiratory Volume2E-626634245
90433Heart Failure2E-620445134
91541Schizophrenia5E-825056061
101021Language3E-625226531

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005539enables glycosaminoglycan binding1IEAHomo_sapiens(9606)Function
GO:0005576located_in extracellular region2HDA,TASHomo_sapiens(9606)Component
GO:0005615located_in extracellular space2HDA,IBAHomo_sapiens(9606)Component
GO:0005796located_in Golgi lumen1TASHomo_sapiens(9606)Component
GO:0009887involved_in animal organ morphogenesis1TASHomo_sapiens(9606)Process
GO:0010508involved_in positive regulation of autophagy1IDAHomo_sapiens(9606)Process
GO:0010596acts_upstream_of_or_within negative regulation of endothelial cell migration1IDAHomo_sapiens(9606)Process
GO:0014068acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase signaling1IDAHomo_sapiens(9606)Process
GO:0016239acts_upstream_of_or_within positive regulation of macroautophagy2IDA,IGIHomo_sapiens(9606)Process
GO:0016525acts_upstream_of_or_within negative regulation of angiogenesis1IDAHomo_sapiens(9606)Process
GO:0019800involved_in peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan1IEAHomo_sapiens(9606)Process
GO:0030021enables extracellular matrix structural constituent conferring compression resistance2ISS,RCAHomo_sapiens(9606)Function
GO:0043202located_in lysosomal lumen1TASHomo_sapiens(9606)Component
GO:0045944acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II1IGIHomo_sapiens(9606)Process
GO:0050840enables extracellular matrix binding1IEAHomo_sapiens(9606)Function
GO:0051901acts_upstream_of_or_within positive regulation of mitochondrial depolarization1IGIHomo_sapiens(9606)Process
GO:0062023colocalizes_with collagen-containing extracellular matrix3HDA,ISSHomo_sapiens(9606)Component
GO:0090141acts_upstream_of_or_within positive regulation of mitochondrial fission1IGIHomo_sapiens(9606)Process
GO:1900747acts_upstream_of_or_within negative regulation of vascular endothelial growth factor signaling pathway1IDAHomo_sapiens(9606)Process

Expression