RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000008086	Gene ID	6792	Accession	11411
Symbol	CDKL5	Alias	DEE2;ISSX;STK9;EIEE2;CFAP247	Full Name	cyclin dependent kinase like 5
Status	Confidence	Length	228047 bases	Strand	Plus strand
Position	X : 18425583 - 18653629	RNA binding domain	N.A.
Summary	This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
27315173	Characterisation of CDKL5 Transcript Isoforms in Human and Mouse.	D Ralph Hector	2016-01-01	PloS one
34605059	CDKL5 kinase controls transcription-coupled responses to DNA damage.	Taran Khanam	2021-12-01	The EMBO journal

Name	Transcript ID	bp	Protein	Translation ID
CDKL5-202	ENST00000379996	3449	1030aa	ENSP00000369332
CDKL5-205	ENST00000623535	14572	960aa	ENSP00000485244
CDKL5-213	ENST00000674046	14695	1001aa	ENSP00000501174
CDKL5-209	ENST00000635828	3823	881aa	ENSP00000490170
CDKL5-211	ENST00000637881	1782	471aa	ENSP00000489879
CDKL5-201	ENST00000379989	3463	1030aa	ENSP00000369325
CDKL5-208	ENST00000624953	567	17aa	ENSP00000485625
CDKL5-204	ENST00000623364	483	60aa	ENSP00000485581
CDKL5-207	ENST00000624700	564	68aa	ENSP00000485359
CDKL5-203	ENST00000463994	2632	784aa	ENSP00000485184
CDKL5-210	ENST00000636046	100	No protein	-
CDKL5-206	ENST00000623610	2130	No protein	-
CDKL5-212	ENST00000673617	378	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
47727	Language Tests	1.4383000E-005	-
48505	Child Development Disorders, Pervasive	2.7162000E-005	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001764	involved_in neuron migration	1	ISS	Homo_sapiens(9606)	Process
GO:0004672	enables protein kinase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0004674	enables protein serine/threonine kinase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0004693	enables cyclin-dependent protein serine/threonine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005813	located_in centrosome	1	IDA	Homo_sapiens(9606)	Component
GO:0006468	involved_in protein phosphorylation	1	IBA	Homo_sapiens(9606)	Process
GO:0016301	enables kinase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0031267	enables small GTPase binding	1	ISS	Homo_sapiens(9606)	Function
GO:0032587	colocalizes_with ruffle membrane	1	ISS	Homo_sapiens(9606)	Component
GO:0032839	is_active_in dendrite cytoplasm	2	IBA,ISS	Homo_sapiens(9606)	Component
GO:0036064	located_in ciliary basal body	1	IDA	Homo_sapiens(9606)	Component
GO:0043547	involved_in positive regulation of GTPase activity	1	ISS	Homo_sapiens(9606)	Process
GO:0044294	located_in dendritic growth cone	1	ISS	Homo_sapiens(9606)	Component
GO:0045773	involved_in positive regulation of axon extension	2	IBA,ISS	Homo_sapiens(9606)	Process
GO:0046777	involved_in protein autophosphorylation	1	IDA	Homo_sapiens(9606)	Process
GO:0048471	located_in perinuclear region of cytoplasm	1	IEA	Homo_sapiens(9606)	Component
GO:0050773	involved_in regulation of dendrite development	2	IBA,ISS	Homo_sapiens(9606)	Process
GO:0050775	involved_in positive regulation of dendrite morphogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0050804	involved_in modulation of chemical synaptic transmission	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0051726	involved_in regulation of cell cycle	1	IEA	Homo_sapiens(9606)	Process
GO:0060999	involved_in positive regulation of dendritic spine development	1	IEA	Homo_sapiens(9606)	Process
GO:0097542	located_in ciliary tip	1	IDA	Homo_sapiens(9606)	Component
GO:0098978	is_active_in glutamatergic synapse	2	IDA,IMP	Homo_sapiens(9606)	Component
GO:0099092	located_in postsynaptic density, intracellular component	1	IEA	Homo_sapiens(9606)	Component
GO:0099175	involved_in regulation of postsynapse organization	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0106310	enables protein serine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:1902017	involved_in regulation of cilium assembly	1	IMP	Homo_sapiens(9606)	Process