RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	Cancer Disease
Drug	N.A.
Main interacting RNAs	tRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000006744	Gene ID	60528	Accession	14198
Symbol	ELAC2	Alias		Full Name
Status	Confidence	Length	26454 bases	Strand	Minus strand
Position	17 : 12991612 - 13018065	RNA binding domain	Lactamase_B_4
Summary

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000337445	Lactamase_B_4	PF13691	5.3e-16	1
ENSP00000379291	Lactamase_B_4	PF13691	8.8e-07	1
ENSP00000405223	Lactamase_B_4	PF13691	4.8e-16	1
ENSP00000477482	Lactamase_B_4	PF13691	7.3e-17	1

Showing 1 to 4 of 4 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hela_human	Hela	Alfredo Castello	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22658674	RIC_PMID22658674_Hs_HeLa	HeLa	Alfredo Castello?	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
25173706	Pclap_PMID25173706_Hs_HEK293	HEK293	Katharina Kramer	2014 Oct;11	doi: 10.1038/nmeth.3092.?Epub 2014 Aug 31
26632259	RIC_PMID26632259._Hs_HuH7	HuH7	Benedikt M Beckmann	2015 Dec 3	doi: 10.1038/ncomms10127.
27453046	RBDmap_PMID_27453046_Hs_HeLa	HeLa	Alfredo Castello	2016 Aug 18	doi: 10.1016/j.molcel.2016.06.029.?Epub 2016 Jul 21
29431736	RICK_PMID29431736_Hs_HeLa.RICK	HeLa	Xichen Bao	2018 Mar	doi: 10.1038/nmeth.4595.?Epub 2018 Feb 12
30528433	XRNAX_PMID30528433_Hs_HEK293	HEK293	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
30528433	XRNAX_PMID30528433_Hs_HeLa	HeLa	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
30528433	XRNAX_PMID30528433_Hs_MCF7	MCF7	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6

Showing 1 to 10 of 19 entries

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
15892892	Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z.	Yang Chen	2005-05-13	BMC molecular biology
23849775	ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy.	B Tobias Haack	2013-08-08	American journal of human genetics
24703694	Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids.	F Daniel Bogenhagen	2014-04-01	Cell metabolism
24926303	The nucleoid as a site of rRNA processing and ribosome assembly.	Alexandra-Viola Bohne	2014-01-01	Frontiers in plant science
27132592	Recessive Mutations in TRMT10C Cause Defects in Mitochondrial RNA Processing and Multiple Respiratory Chain Deficiencies.	D Metodi Metodiev	2016-05-05	American journal of human genetics
27926991	Human mitochondrial nucleases.	Francesco Bruni	2017-06-01	The FEBS journal
28379452	The crystal structure of Trz1, the long form RNase Z from yeast.	Miao Ma	2017-06-02	Nucleic acids research
29954949	The S. pombe mitochondrial transcriptome.	Jinjie Shang	2018-09-01	RNA (New York, N.Y.)
33314036	The Diseased Mitoribosome.	Alberto Ferrari	2021-04-01	FEBS letters
34071708	Engineering Genetic Systems for Treating Mitochondrial Diseases.	Yoon-Ha Jang	2021-05-28	Pharmaceutics

Showing 1 to 10 of 14 entries

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
ELAC2-201	ENST00000338034	3767	826aa	ENSP00000337445
ELAC2-202	ENST00000395962	2924	807aa	ENSP00000379291
ELAC2-203	ENST00000426905	2671	786aa	ENSP00000405223
ELAC2-204	ENST00000446899	858	286aa	ENSP00000406192
ELAC2-205	ENST00000465825	2793	No protein	-
ELAC2-206	ENST00000476042	428	45aa	ENSP00000463884
ELAC2-207	ENST00000480891	2737	No protein	-
ELAC2-208	ENST00000484122	3738	No protein	-
ELAC2-209	ENST00000487229	2452	No protein	-
ELAC2-210	ENST00000491478	758	No protein	-

Showing 1 to 10 of 21 entries

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Gene Model

Click here to download ENSG00000006744's gene model file

Phenotypes

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ensgID	Trait	pValue	Pubmed ID
373	Respiratory Function Tests	8.12171927270868E-6	17903307
9593	Echocardiography	6.71965115106588E-5	17903301
9606	Echocardiography	8.85489686242025E-5	17903301
11745	Walking	2.68096320554501E-5	17903295
11759	Walking	2.68096320554501E-5	17903295
14741	Hemoglobin A, Glycosylated	6.4100000E-005	19875614
17394	Cholesterol, LDL	1.998e-005	19060910
27901	Blood Glucose	6.6180000E-005	-
28355	Insulin	7.7770000E-005	-
30489	Eosinophils	8.6130000E-005	-

Showing 1 to 10 of 30 entries

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GWAS

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
ENSG00000006744	rs9908102	17	12993236	Schizophrenia	26198764	1.05	EFO_0000692

Showing 1 to 1 of 1 entries

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Protein-Protein Interaction (PPI)

Click here to download ENSG00000006744's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000006744	homo_sapiens	ENSP00000269466	43.8017	25.8953	homo_sapiens	ENSP00000337445	19.2494	11.3801

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000006744	homo_sapiens	ENSP00000337445	94.7942	92.7361	nomascus_leucogenys	ENSNLEP00000017789	96.31	94.2189
ENSG00000006744	homo_sapiens	ENSP00000337445	99.2736	98.9104	pan_paniscus	ENSPPAP00000002778	99.2736	98.9104
ENSG00000006744	homo_sapiens	ENSP00000337445	97.9419	96.6102	pongo_abelii	ENSPPYP00000042310	98.0606	96.7273
ENSG00000006744	homo_sapiens	ENSP00000337445	99.3947	98.9104	pan_troglodytes	ENSPTRP00000081112	99.3947	98.9104
ENSG00000006744	homo_sapiens	ENSP00000337445	99.2736	98.7893	gorilla_gorilla	ENSGGOP00000015469	99.2736	98.7893
ENSG00000006744	homo_sapiens	ENSP00000337445	67.0702	55.569	ornithorhynchus_anatinus	ENSOANP00000036886	69.0773	57.2319
ENSG00000006744	homo_sapiens	ENSP00000337445	82.3245	70.339	sarcophilus_harrisii	ENSSHAP00000031353	80.6643	68.9205
ENSG00000006744	homo_sapiens	ENSP00000337445	60.4116	51.937	notamacropus_eugenii	ENSMEUP00000000013	61.9107	53.2258
ENSG00000006744	homo_sapiens	ENSP00000337445	82.8087	74.4552	dasypus_novemcinctus	ENSDNOP00000003269	83.7209	75.2754
ENSG00000006744	homo_sapiens	ENSP00000337445	68.6441	60.8959	erinaceus_europaeus	ENSEEUP00000009849	69.656	61.7936

Showing 1 to 10 of 195 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005739	is_active_in mitochondrion	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0004521	enables RNA endonuclease activity	1	TAS	Homo_sapiens(9606)	Function
GO:0004549	enables tRNA-specific ribonuclease activity	1	EXP	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005759	located_in mitochondrial matrix	1	TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0016078	involved_in tRNA catabolic process	1	TAS	Homo_sapiens(9606)	Process
GO:0042645	located_in mitochondrial nucleoid	1	IDA	Homo_sapiens(9606)	Component

Showing 1 to 10 of 15 entries

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression