Welcome to
RBP World!
Description
| Ensembl ID | ENSG00000005339 | Gene ID | 1387 | Accession | 2348 |
| Symbol | CREBBP | Alias | CBP;RSTS;KAT3A;MKHK1;RSTS1 | Full Name | CREB binding protein |
| Status | Confidence | Length | 155660 bases | Strand | Minus strand |
| Position | 16 : 3725054 - 3880713 | RNA binding domain | Creb_binding | ||
| Summary | This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009] | ||||
RNA binding proteomes (RBPomes)
| Pubmed ID | Full Name | Cell | Author | Time | Doi |
|---|
Literatures on RNA binding capacity
| Pubmed ID | Title | Author | Time | Journal |
|---|---|---|---|---|
| 27536004 | The bromodomain protein BRD4 regulates splicing during heat shock. | Michelle Hussong | 2017-01-09 | Nucleic acids research |
| 31312255 | Is an analysis of copy number variants necessary for various types of kidney ultrasound anomalies in fetuses? | Shaobin Lin | 2019-01-01 | Molecular cytogenetics |
| 32086317 | Splicing of enhancer-associated lincRNAs contributes to enhancer activity. | Y Jennifer Tan | 2020-04-01 | Life science alliance |
| 35015755 | The activity of human enhancers is modulated by the splicing of their associated lncRNAs. | Yihong Jennifer Tan | 2022-01-01 | PLoS computational biology |
| 34759793 | Interconnected Gene Networks Underpin the Clinical Overlap of HNRNPH1-Related and Rubinstein-Taybi Intellectual Disability Syndromes. | Lidia Larizza | 2021-01-01 | Frontiers in neuroscience |
Transcripts
| Name | Transcript ID | bp | Protein | Translation ID |
|---|---|---|---|---|
| CREBBP-201 | ENST00000262367 | 10790 | 2442aa | ENSP00000262367 |
| CREBBP-202 | ENST00000382070 | 7598 | 2404aa | ENSP00000371502 |
| CREBBP-219 | ENST00000637492 | 100 | 33aa | ENSP00000490244 |
| CREBBP-204 | ENST00000571763 | 548 | No protein | - |
| CREBBP-212 | ENST00000576720 | 3578 | No protein | - |
| CREBBP-203 | ENST00000570939 | 3316 | 1105aa | ENSP00000461002 |
| CREBBP-210 | ENST00000574740 | 523 | No protein | - |
| CREBBP-208 | ENST00000573517 | 718 | 196aa | ENSP00000460474 |
| CREBBP-207 | ENST00000572569 | 553 | No protein | - |
| CREBBP-216 | ENST00000635919 | 100 | No protein | - |
| CREBBP-220 | ENST00000638158 | 97 | No protein | - |
| CREBBP-209 | ENST00000573672 | 922 | No protein | - |
| CREBBP-205 | ENST00000571826 | 627 | 181aa | ENSP00000459490 |
| CREBBP-206 | ENST00000572134 | 846 | 254aa | ENSP00000458254 |
| CREBBP-211 | ENST00000575237 | 403 | No protein | - |
| CREBBP-213 | ENST00000634839 | 339 | No protein | - |
| CREBBP-217 | ENST00000636002 | 84 | No protein | - |
| CREBBP-214 | ENST00000635753 | 100 | No protein | - |
| CREBBP-215 | ENST00000635899 | 100 | No protein | - |
| CREBBP-218 | ENST00000636895 | 100 | No protein | - |
Phenotypes
| ensgID | Trait | pValue | Pubmed ID |
|---|---|---|---|
| 2771 | Body Weights and Measures | 2.45314842894787E-6 | 17903300 |
| 2781 | Body Weights and Measures | 2.66366128675991E-6 | 17903300 |
| 73283 | Electrocardiography | 9E-6 | 23459443 |
| 80632 | Insulin-Like Growth Factor Binding Protein 3 | 9E-6 | 23251661 |
| 87112 | Neurofibrillary Tangles | 4E-6 | 25188341 |
| 88260 | Cleft Lip | 9E-12 | 25775280 |
| 88261 | Cleft Palate | 9E-12 | 25775280 |
| 94069 | Electrocardiography | 4E-10 | 24952745 |
| 100278 | Cleft Lip | 1E-10 | 28232668 |
| 100279 | Cleft Palate | 1E-10 | 28232668 |
GWAS
| ensgID | SNP | Chromosome | Position | Trait | PubmedID | Or or BEAT | EFO ID |
|---|
Protein-Protein Interaction (PPI)
Paralogs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Orthologs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Gene Ontology
| Go ID | Go term | No. evidence | Entries | Species | Category |
|---|---|---|---|---|---|
| GO:0000122 | involved_in negative regulation of transcription by RNA polymerase II | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0000123 | part_of histone acetyltransferase complex | 1 | IBA | Homo_sapiens(9606) | Component |
| GO:0000785 | part_of chromatin | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0001223 | enables transcription coactivator binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0001666 | involved_in response to hypoxia | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0002039 | enables p53 binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0002223 | involved_in stimulatory C-type lectin receptor signaling pathway | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0003682 | enables chromatin binding | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0003684 | enables damaged DNA binding | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0003713 | enables transcription coactivator activity | 4 | IBA,IDA,IPI,TAS | Homo_sapiens(9606) | Function |
| GO:0003714 | enables transcription corepressor activity | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0004402 | enables histone acetyltransferase activity | 3 | IBA,IDA,TAS | Homo_sapiens(9606) | Function |
| GO:0005515 | enables protein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0005634 | located_in nucleus | 2 | IC,IDA | Homo_sapiens(9606) | Component |
| GO:0005654 | located_in nucleoplasm | 2 | IDA,TAS | Homo_sapiens(9606) | Component |
| GO:0005667 | part_of transcription regulator complex | 1 | IBA | Homo_sapiens(9606) | Component |
| GO:0005737 | is_active_in cytoplasm | 2 | IDA | Homo_sapiens(9606) | Component |
| GO:0005829 | located_in cytosol | 1 | TAS | Homo_sapiens(9606) | Component |
| GO:0006338 | involved_in chromatin remodeling | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0006351 | involved_in DNA-templated transcription | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0006355 | involved_in regulation of DNA-templated transcription | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0006473 | involved_in protein acetylation | 2 | IDA,TAS | Homo_sapiens(9606) | Process |
| GO:0007165 | involved_in signal transduction | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:0008270 | enables zinc ion binding | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0008589 | involved_in regulation of smoothened signaling pathway | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0016407 | enables acetyltransferase activity | 2 | EXP,IDA | Homo_sapiens(9606) | Function |
| GO:0016479 | involved_in negative regulation of transcription by RNA polymerase I | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0016573 | involved_in histone acetylation | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0016604 | located_in nuclear body | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0018076 | involved_in N-terminal peptidyl-lysine acetylation | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0030511 | involved_in positive regulation of transforming growth factor beta receptor signaling pathway | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0031490 | enables chromatin DNA binding | 1 | IBA | Homo_sapiens(9606) | Function |
| GO:0031648 | involved_in protein destabilization | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0031669 | involved_in cellular response to nutrient levels | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0034212 | enables peptide N-acetyltransferase activity | 1 | TAS | Homo_sapiens(9606) | Function |
| GO:0034644 | involved_in cellular response to UV | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0038061 | involved_in NIK/NF-kappaB signaling | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0042592 | involved_in homeostatic process | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:0042733 | involved_in embryonic digit morphogenesis | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0043426 | enables MRF binding | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:0045893 | involved_in positive regulation of DNA-templated transcription | 2 | IDA,ISS | Homo_sapiens(9606) | Process |
| GO:0045944 | involved_in positive regulation of transcription by RNA polymerase II | 2 | IBA,IDA | Homo_sapiens(9606) | Process |
| GO:0048511 | involved_in rhythmic process | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0061629 | enables RNA polymerase II-specific DNA-binding transcription factor binding | 2 | IPI,TAS | Homo_sapiens(9606) | Function |
| GO:0061733 | enables peptide-lysine-N-acetyltransferase activity | 2 | EXP,IDA | Homo_sapiens(9606) | Function |
| GO:0065003 | involved_in protein-containing complex assembly | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:0140297 | enables DNA-binding transcription factor binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:1900034 | involved_in regulation of cellular response to heat | 1 | TAS | Homo_sapiens(9606) | Process |
| GO:1900182 | involved_in positive regulation of protein localization to nucleus | 1 | IDA | Homo_sapiens(9606) | Process |