RBP Type	Non-canonical_RBPs
Diseases	FlavivirusesSARS-COV-2Dengue
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq

Ensembl ID	ENSG00000005156	Gene ID	3980	Accession	6600
Symbol	LIG3	Alias	LIG2;MTDPS20;LIG3alpha	Full Name	DNA ligase 3
Status	Confidence	Length	29232 bases	Strand	Plus strand
Position	17 : 34980512 - 35009743	RNA binding domain	N.A.
Summary	This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
34464389	R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements.	A David Ellis	2021-08-01	PLoS genetics

Name	Transcript ID	bp	Protein	Translation ID
LIG3-202	ENST00000378526	8382	1009aa	ENSP00000367787
LIG3-205	ENST00000585941	1699	545aa	ENSP00000468479
LIG3-201	ENST00000262327	3055	949aa	ENSP00000262327
LIG3-215	ENST00000592690	722	207aa	ENSP00000467063
LIG3-204	ENST00000585740	887	185aa	ENSP00000467757
LIG3-212	ENST00000590181	1156	No protein	-
LIG3-208	ENST00000586407	815	No protein	-
LIG3-210	ENST00000588109	592	38aa	ENSP00000466278
LIG3-209	ENST00000586435	588	No protein	-
LIG3-213	ENST00000590630	904	No protein	-
LIG3-206	ENST00000586058	581	No protein	-
LIG3-211	ENST00000588713	467	No protein	-
LIG3-216	ENST00000593099	4664	No protein	-
LIG3-207	ENST00000586119	565	No protein	-
LIG3-203	ENST00000585370	235	36aa	ENSP00000465288
LIG3-214	ENST00000592244	440	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
82399	Electrocardiography	6E-12	19305408
85401	Electrocardiography	6E-25	24952745

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000724	involved_in double-strand break repair via homologous recombination	1	TAS	Homo_sapiens(9606)	Process
GO:0003677	enables DNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0003909	enables DNA ligase activity	2	IDA,TAS	Homo_sapiens(9606)	Function
GO:0003910	enables DNA ligase (ATP) activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005739	located_in mitochondrion	1	IEA	Homo_sapiens(9606)	Component
GO:0006273	involved_in lagging strand elongation	1	IBA	Homo_sapiens(9606)	Process
GO:0006287	involved_in base-excision repair, gap-filling	1	TAS	Homo_sapiens(9606)	Process
GO:0006288	involved_in base-excision repair, DNA ligation	3	IBA,IDA,TAS	Homo_sapiens(9606)	Process
GO:0006302	involved_in double-strand break repair	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0007049	involved_in cell cycle	1	IEA	Homo_sapiens(9606)	Process
GO:0008270	enables zinc ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0033151	NOT involved_in V(D)J recombination	1	IDA	Homo_sapiens(9606)	Process
GO:0051301	involved_in cell division	1	IEA	Homo_sapiens(9606)	Process
GO:0070421	part_of DNA ligase III-XRCC1 complex	1	IBA	Homo_sapiens(9606)	Component
GO:0071897	involved_in DNA biosynthetic process	1	IEA	Homo_sapiens(9606)	Process
GO:0090298	involved_in negative regulation of mitochondrial DNA replication	1	IMP	Homo_sapiens(9606)	Process