RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000004455	Gene ID	204	Accession	362
Symbol	AK2	Alias	ADK2	Full Name	adenylate kinase 2
Status	Confidence	Length	29019 bases	Strand	Minus strand
Position	1 : 33007986 - 33037004	RNA binding domain	ADK_lid
Summary	Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000449003	ADK_lid	PF05191	1.4e-16	1
ENSP00000346921	ADK_lid	PF05191	1.5e-16	1
ENSP00000447082	ADK_lid	PF05191	1.9e-16	1
ENSP00000362548	ADK_lid	PF05191	1.9e-16	1
ENSP00000499935	ADK_lid	PF05191	2e-16	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
AK2-202	ENST00000373449	3597	232aa	ENSP00000362548
AK2-214	ENST00000672715	5970	239aa	ENSP00000499935
AK2-216	ENST00000695598	6153	No protein	-
AK2-217	ENST00000695599	7687	43aa	ENSP00000512046
AK2-211	ENST00000550338	2832	42aa	ENSP00000450008
AK2-201	ENST00000354858	5059	197aa	ENSP00000346921
AK2-218	ENST00000695600	6318	No protein	-
AK2-219	ENST00000695601	2862	42aa	ENSP00000512047
AK2-220	ENST00000695602	4535	42aa	ENSP00000512048
AK2-208	ENST00000491241	3110	42aa	ENSP00000512049
AK2-205	ENST00000469238	6140	No protein	-
AK2-221	ENST00000695603	3879	No protein	-
AK2-222	ENST00000695604	3044	162aa	ENSP00000512050
AK2-213	ENST00000672308	2840	No protein	-
AK2-209	ENST00000548033	936	190aa	ENSP00000449003
AK2-204	ENST00000467905	880	232aa	ENSP00000447082
AK2-206	ENST00000480134	811	133aa	ENSP00000450109
AK2-203	ENST00000466029	223	No protein	-
AK2-223	ENST00000695605	3546	42aa	ENSP00000512051
AK2-215	ENST00000673291	3040	162aa	ENSP00000500549
AK2-207	ENST00000487289	920	162aa	ENSP00000446849
AK2-210	ENST00000548559	530	No protein	-
AK2-212	ENST00000551979	581	No protein	-
AK2-224	ENST00000695606	2303	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
66225	Amyloidosis, Cerebral, with Spongiform Encephalopathy	6E-7	26252872
104864	Gastrointestinal Microbiome	5E-8	27723756

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004017	enables adenylate kinase activity	2	EXP,IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0005739	is_active_in mitochondrion	1	IBA	Homo_sapiens(9606)	Component
GO:0005758	located_in mitochondrial intermembrane space	1	TAS	Homo_sapiens(9606)	Component
GO:0006172	involved_in ADP biosynthetic process	1	IEA	Homo_sapiens(9606)	Process
GO:0015949	involved_in nucleobase-containing small molecule interconversion	1	TAS	Homo_sapiens(9606)	Process
GO:0016310	involved_in phosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0046033	involved_in AMP metabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0046034	involved_in ATP metabolic process	1	IEA	Homo_sapiens(9606)	Process
GO:0046940	involved_in nucleoside monophosphate phosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:0097226	located_in sperm mitochondrial sheath	1	IEA	Homo_sapiens(9606)	Component