RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000001630	Gene ID	1595	Accession	2649
Symbol	CYP51A1	Alias	LDM;CP51;CYP51;CYPL1;P450L1;P450-14DM	Full Name	cytochrome P450 family 51 subfamily A member 1
Status	Confidence	Length	49817 bases	Strand	Minus strand
Position	7 : 92084987 - 92134803	RNA binding domain	N.A.
Summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
CYP51A1-205	ENST00000691309	2106	458aa	ENSP00000510368
CYP51A1-201	ENST00000003100	3155	509aa	ENSP00000003100
CYP51A1-203	ENST00000450723	1729	404aa	ENSP00000406757
CYP51A1-202	ENST00000422867	747	222aa	ENSP00000394268
CYP51A1-204	ENST00000482924	555	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
70299	Longevity	2E-8	25918517

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005506	enables iron ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005783	located_in endoplasmic reticulum	1	IDA	Homo_sapiens(9606)	Component
GO:0005789	located_in endoplasmic reticulum membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0006694	involved_in steroid biosynthetic process	1	IDA	Homo_sapiens(9606)	Process
GO:0006695	involved_in cholesterol biosynthetic process	1	TAS	Homo_sapiens(9606)	Process
GO:0008398	enables sterol 14-demethylase activity	2	IDA,TAS	Homo_sapiens(9606)	Function
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0016125	involved_in sterol metabolic process	2	IBA,TAS	Homo_sapiens(9606)	Process
GO:0016491	enables oxidoreductase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0020037	enables heme binding	1	IDA	Homo_sapiens(9606)	Function
GO:0042177	involved_in negative regulation of protein catabolic process	1	ISS	Homo_sapiens(9606)	Process
GO:0050709	involved_in negative regulation of protein secretion	1	ISS	Homo_sapiens(9606)	Process
GO:1900222	involved_in negative regulation of amyloid-beta clearance	1	ISS	Homo_sapiens(9606)	Process