Drugs target to PCSK9

Drug name Drug type Disease/phenotype Mechanism of action(MoA) Phase Status Source
EVOLOCUMABAntibodycoronary artery diseaseSubtilisin/kexin type 9 inhibitor3.0Active, not recruitingClinicalTrials
ALIROCUMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
EVOLOCUMABAntibodyhomozygous familial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor2.0CompletedClinicalTrials
ALIROCUMABAntibodyperipheral arterial diseaseSubtilisin/kexin type 9 inhibitor4.0Active, not recruitingClinicalTrials
EVOLOCUMABAntibodyhomozygous familial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor3.0Active, not recruitingClinicalTrials
TAFOLECIMABAntibodyfamilial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
EVOLOCUMABAntibodycardiovascular diseaseSubtilisin/kexin type 9 inhibitor2.0CompletedClinicalTrials
INCLISIRANOligonucleotidecardiovascular diseasePCSK9 mRNA RNAi inhibitor3.0CompletedClinicalTrials
EVOLOCUMABAntibodycarotid artery diseaseSubtilisin/kexin type 9 inhibitor4.0RecruitingClinicalTrials
EVOLOCUMABAntibodyacute coronary syndromeSubtilisin/kexin type 9 inhibitor2.0RecruitingClinicalTrials
EVOLOCUMABAntibodyhyperlipidemiaSubtilisin/kexin type 9 inhibitor2.0CompletedClinicalTrials
EVOLOCUMABAntibodystrokeSubtilisin/kexin type 9 inhibitor4.0-DailyMed
EVOLOCUMABAntibodyacute coronary syndromeSubtilisin/kexin type 9 inhibitor2.0Active, not recruitingClinicalTrials
BOCOCIZUMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor1.0CompletedClinicalTrials
RALPANCIZUMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor1.0CompletedClinicalTrials
INCLISIRANOligonucleotidehyperlipidemiaPCSK9 mRNA RNAi inhibitor1.0CompletedClinicalTrials
INCLISIRANOligonucleotideHypercholesterolemiaPCSK9 mRNA RNAi inhibitor4.0RecruitingClinicalTrials
EVOLOCUMABAntibodycoronary artery diseaseSubtilisin/kexin type 9 inhibitor4.0WithdrawnClinicalTrials
EVOLOCUMABAntibodycoronary artery diseaseSubtilisin/kexin type 9 inhibitor4.0RecruitingClinicalTrials
EVOLOCUMABAntibodycerebral atherosclerosisSubtilisin/kexin type 9 inhibitor4.0Not yet recruitingClinicalTrials
ONGERICIMABAntibodycancerSubtilisin/kexin type 9 inhibitor1.0RecruitingClinicalTrials
LERODALCIBEPProteincardiovascular diseaseSubtilisin/kexin type 9 inhibitor3.0Active, not recruitingClinicalTrials
EVOLOCUMABAntibodyhyperlipidemiaSubtilisin/kexin type 9 inhibitor4.0RecruitingClinicalTrials
ALIROCUMABAntibodycardiovascular diseaseSubtilisin/kexin type 9 inhibitor4.0-ATC
INCLISIRANOligonucleotidecardiovascular diseasePCSK9 mRNA RNAi inhibitor3.0RecruitingClinicalTrials
BOCOCIZUMABAntibodyfamilial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
ONGERICIMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor1.0CompletedClinicalTrials
ALIROCUMABAntibodyfamilial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor4.0TerminatedClinicalTrials
ONGERICIMABAntibodyhyperlipidemiaSubtilisin/kexin type 9 inhibitor2.0Active, not recruitingClinicalTrials
EVOLOCUMABAntibodyCOVID-19Subtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
EVOLOCUMABAntibodyST Elevation Myocardial InfarctionSubtilisin/kexin type 9 inhibitor4.0Not yet recruitingClinicalTrials
FROVOCIMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor1.0CompletedClinicalTrials
INCLISIRAN SODIUMOligonucleotideatherosclerosisPCSK9 mRNA rnai inhibitor4.0-FDA
EVOLOCUMABAntibodynon-small cell lung carcinomaSubtilisin/kexin type 9 inhibitor1.0RecruitingClinicalTrials
BOCOCIZUMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor2.0CompletedClinicalTrials
TAFOLECIMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor2.0Unknown statusClinicalTrials
EVOLOCUMABAntibodyglioblastoma multiformeSubtilisin/kexin type 9 inhibitor0.5RecruitingClinicalTrials
EVOLOCUMABAntibodyheart failureSubtilisin/kexin type 9 inhibitor2.0CompletedClinicalTrials
ALIROCUMABAntibodyfamilial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
INCLISIRANOligonucleotideacute coronary syndromePCSK9 mRNA RNAi inhibitor3.0RecruitingClinicalTrials
INCLISIRANOligonucleotidehomozygous familial hypercholesterolemiaPCSK9 mRNA RNAi inhibitor2.0CompletedClinicalTrials
ALIROCUMABAntibodyacute myocardial infarctionSubtilisin/kexin type 9 inhibitor4.0RecruitingClinicalTrials
EVOLOCUMABAntibodyhyperlipidemiaSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
EVOLOCUMABAntibodyhomozygous familial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor4.0CompletedClinicalTrials
ALIROCUMABAntibodycoronary artery diseaseSubtilisin/kexin type 9 inhibitor4.0RecruitingClinicalTrials
EVOLOCUMABAntibodycardiovascular diseaseSubtilisin/kexin type 9 inhibitor2.0RecruitingClinicalTrials
ALIROCUMABAntibodyfamilial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor4.0CompletedClinicalTrials
EVOLOCUMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor2.0CompletedClinicalTrials
EVOLOCUMABAntibodymyocardial infarctionSubtilisin/kexin type 9 inhibitor4.0-DailyMed
EVOLOCUMABAntibodyIschemic strokeSubtilisin/kexin type 9 inhibitor4.0WithdrawnClinicalTrials
EVOLOCUMABAntibodyperipheral arterial diseaseSubtilisin/kexin type 9 inhibitor4.0RecruitingClinicalTrials
EVOLOCUMABAntibodyacute coronary syndromeSubtilisin/kexin type 9 inhibitor4.0RecruitingClinicalTrials
TAFOLECIMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor1.0CompletedClinicalTrials
EVOLOCUMABAntibodycardiovascular diseaseSubtilisin/kexin type 9 inhibitor4.0-DailyMed,ATC
BOCOCIZUMABAntibodyhyperlipidemiaSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
EVOLOCUMABAntibodyfamilial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor4.0TerminatedClinicalTrials
ONGERICIMABAntibodyhyperlipidemiaSubtilisin/kexin type 9 inhibitor3.0Active, not recruitingClinicalTrials
EVOLOCUMABAntibodyST Elevation Myocardial InfarctionSubtilisin/kexin type 9 inhibitor4.0RecruitingClinicalTrials
EVOLOCUMABAntibodyhyperlipoproteinemia type 3Subtilisin/kexin type 9 inhibitor4.0Unknown statusClinicalTrials
ONGERICIMABAntibodyfamilial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor3.0RecruitingClinicalTrials
ALIROCUMABAntibodycoronary artery diseaseSubtilisin/kexin type 9 inhibitor4.0-DailyMed
EVOLOCUMABAntibodytype 2 diabetes mellitusSubtilisin/kexin type 9 inhibitor4.0CompletedClinicalTrials
ALIROCUMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor1.0CompletedClinicalTrials
INCLISIRANOligonucleotidefamilial hypercholesterolemiaPCSK9 mRNA RNAi inhibitor3.0CompletedClinicalTrials
LERODALCIBEPProteinHypercholesterolemiaSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
INCLISIRANOligonucleotidecardiovascular diseasePCSK9 mRNA RNAi inhibitor3.0Active, not recruitingClinicalTrials
BOCOCIZUMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor1.0TerminatedClinicalTrials
EVOLOCUMABAntibodySepsisSubtilisin/kexin type 9 inhibitor2.0RecruitingClinicalTrials
ALIROCUMABAntibodyatherosclerosisSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
EVOLOCUMABAntibodychronic kidney diseaseSubtilisin/kexin type 9 inhibitor4.0WithdrawnClinicalTrials
EVOLOCUMABAntibodyST Elevation Myocardial InfarctionSubtilisin/kexin type 9 inhibitor2.0WithdrawnClinicalTrials
ALIROCUMABAntibodynon-small cell lung carcinomaSubtilisin/kexin type 9 inhibitor2.0Not yet recruitingClinicalTrials
TAFOLECIMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
ALIROCUMABAntibodyinflammationSubtilisin/kexin type 9 inhibitor4.0WithdrawnClinicalTrials
ALIROCUMABAntibodySepsisSubtilisin/kexin type 9 inhibitor1.0Not yet recruitingClinicalTrials
ALIROCUMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor2.0CompletedClinicalTrials
LERODALCIBEPProteinfamilial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor3.0Active, not recruitingClinicalTrials
EVOLOCUMABAntibodyhyperlipidemiaSubtilisin/kexin type 9 inhibitor1.0CompletedClinicalTrials
LERODALCIBEPProteinhomozygous familial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor3.0Active, not recruitingClinicalTrials
EVOLOCUMABAntibodyacute coronary syndromeSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
ALIROCUMABAntibodyfamilial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor4.0-DailyMed
ALIROCUMABAntibodyfamilial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor2.0CompletedClinicalTrials
EVOLOCUMABAntibodyinflammationSubtilisin/kexin type 9 inhibitor4.0WithdrawnClinicalTrials
ALIROCUMABAntibodycardiovascular diseaseSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
ALIROCUMABAntibodynephrotic syndromeSubtilisin/kexin type 9 inhibitor2.0TerminatedClinicalTrials
INCLISIRANOligonucleotideHypercholesterolemiaPCSK9 mRNA RNAi inhibitor1.0CompletedClinicalTrials
EVOLOCUMABAntibodyischemiaSubtilisin/kexin type 9 inhibitor4.0RecruitingClinicalTrials
EVOLOCUMABAntibodyfamilial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor2.0CompletedClinicalTrials
EVOLOCUMABAntibodycardiovascular diseaseSubtilisin/kexin type 9 inhibitor4.0CompletedClinicalTrials
ALIROCUMABAntibodyDisorder of lipid metabolismSubtilisin/kexin type 9 inhibitor2.0CompletedClinicalTrials
INCLISIRANOligonucleotidefamilial hypercholesterolemiaPCSK9 mRNA RNAi inhibitor3.0RecruitingClinicalTrials
EVOLOCUMABAntibodylung cancerSubtilisin/kexin type 9 inhibitor2.0RecruitingClinicalTrials
EVOLOCUMABAntibodyIschemic strokeSubtilisin/kexin type 9 inhibitor4.0TerminatedClinicalTrials
FROVOCIMABAntibodyhyperlipidemiaSubtilisin/kexin type 9 inhibitor1.0CompletedClinicalTrials
ALIROCUMABAntibodyDisorder of lipid metabolismSubtilisin/kexin type 9 inhibitor4.0CompletedClinicalTrials
EVOLOCUMABAntibodyCombined hyperlipidemiaSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
ONGERICIMABAntibodyCombined hyperlipidemiaSubtilisin/kexin type 9 inhibitor3.0Not yet recruitingClinicalTrials
EVOLOCUMABAntibodyNon-ST Elevation Myocardial InfarctionSubtilisin/kexin type 9 inhibitor4.0RecruitingClinicalTrials
EVOLOCUMABAntibodyinternal carotid artery stenosisSubtilisin/kexin type 9 inhibitor4.0Active, not recruitingClinicalTrials
ALIROCUMABAntibodyDisorder of lipid metabolismSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
INCLISIRANOligonucleotidehomozygous familial hypercholesterolemiaPCSK9 mRNA RNAi inhibitor3.0CompletedClinicalTrials
ALIROCUMABAntibodyhomozygous familial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
ALIROCUMABAntibodydiabetes mellitusSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
EVOLOCUMABAntibodyatherosclerosisSubtilisin/kexin type 9 inhibitor4.0RecruitingClinicalTrials
EVOLOCUMABAntibodyDisorder of lipid metabolismSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
ALIROCUMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor4.0CompletedClinicalTrials
FROVOCIMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor2.0CompletedClinicalTrials
BOCOCIZUMABAntibodycardiovascular diseaseSubtilisin/kexin type 9 inhibitor3.0TerminatedClinicalTrials
ONGERICIMABAntibodyhyperlipidemiaSubtilisin/kexin type 9 inhibitor3.0RecruitingClinicalTrials
INCLISIRAN SODIUMOligonucleotidefamilial hypercholesterolemiaPCSK9 mRNA rnai inhibitor4.0-FDA
INCLISIRANOligonucleotidekidney diseasePCSK9 mRNA RNAi inhibitor1.0CompletedClinicalTrials
EVOLOCUMABAntibodyfamilial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
TAFOLECIMABAntibodyhomozygous familial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor2.0Active, not recruitingClinicalTrials
EVOLOCUMABAntibodycoronary artery diseaseSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
EVOLOCUMABAntibodycoronary artery diseaseSubtilisin/kexin type 9 inhibitor4.0-DailyMed
EVOLOCUMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor3.0CompletedClinicalTrials
EVOLOCUMABAntibodyfamilial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor4.0-DailyMed
TAFOLECIMABAntibodyHypercholesterolemiaSubtilisin/kexin type 9 inhibitor3.0RecruitingClinicalTrials
EVOLOCUMABAntibodyReduced left ventricular ejection fractionSubtilisin/kexin type 9 inhibitor2.0CompletedClinicalTrials
INCLISIRANOligonucleotideHypercholesterolemiaPCSK9 mRNA RNAi inhibitor3.0Active, not recruitingClinicalTrials
INCLISIRANOligonucleotidecardiovascular diseasePCSK9 mRNA RNAi inhibitor4.0-ATC
INCLISIRANOligonucleotidecoronary artery diseasePCSK9 mRNA RNAi inhibitor3.0RecruitingClinicalTrials
ALIROCUMABAntibodyatherosclerosisSubtilisin/kexin type 9 inhibitor4.0TerminatedClinicalTrials
TAFOLECIMABAntibodyfamilial hypercholesterolemiaSubtilisin/kexin type 9 inhibitor2.0RecruitingClinicalTrials