Drugs target to TP53

Drug name Drug type Disease/phenotype Mechanism of action(MoA) Phase Status Source
IDASANUTLINSmall moleculediffuse large B-cell lymphomaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0TerminatedClinicalTrials
TEPRASIRANOligonucleotideAcute kidney injuryp53 mRNA RNAi inhibitor2.0CompletedClinicalTrials
IDASANUTLINSmall moleculepolycythemia veraTumour suppressor p53/oncoprotein Mdm2 inhibitor2.0TerminatedClinicalTrials
IDASANUTLINSmall moleculeessential thrombocythemiaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0CompletedClinicalTrials
IDASANUTLINSmall moleculeacute myeloid leukemiaTumour suppressor p53/oncoprotein Mdm2 inhibitor3.0TerminatedClinicalTrials
IDASANUTLINSmall moleculebreast cancerTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0TerminatedClinicalTrials
NAVTEMADLINSmall moleculemelanomaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0CompletedClinicalTrials
IDASANUTLINSmall moleculemultiple myelomaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0Active, not recruitingClinicalTrials
NAVTEMADLINSmall moleculeacute myeloid leukemiaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0CompletedClinicalTrials
NAVTEMADLINSmall moleculesmall cell lung carcinomaTumour suppressor p53/oncoprotein Mdm2 inhibitor2.0RecruitingClinicalTrials
TEPRASIRANOligonucleotideAcute kidney injuryp53 mRNA RNAi inhibitor1.0TerminatedClinicalTrials
NAVTEMADLINSmall moleculemultiple myelomaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
IDASANUTLINSmall moleculenon-Hodgkins lymphomaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0TerminatedClinicalTrials
EPRENETAPOPTSmall moleculeesophageal carcinomaCellular tumor antigen p53 stabiliser1.0TerminatedClinicalTrials
NAVTEMADLINSmall moleculeessential thrombocythemiaTumour suppressor p53/oncoprotein Mdm2 inhibitor2.0RecruitingClinicalTrials
APG115Small moleculelymphomaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0CompletedClinicalTrials
IDASANUTLINSmall moleculecolorectal carcinomaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0TerminatedClinicalTrials
NAVTEMADLINSmall moleculesoft tissue sarcomaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0Active, not recruitingClinicalTrials
SIREMADLINSmall moleculeacute myeloid leukemiaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0TerminatedClinicalTrials
EPRENETAPOPTSmall moleculemyeloid neoplasmCellular tumor antigen p53 stabiliser1.0CompletedClinicalTrials
CONTUSUGENE LADENOVECGeneliver cancerCellular tumor antigen p53 positive modulator1.0TerminatedClinicalTrials
APG115Small moleculemyelodysplastic syndromeTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
SIREMADLINSmall moleculeUveal MelanomaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0TerminatedClinicalTrials
IDASANUTLINSmall moleculeacute myeloid leukemiaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0TerminatedClinicalTrials
EPRENETAPOPTSmall moleculeMantle cell lymphomaCellular tumor antigen p53 stabiliser2.0WithdrawnClinicalTrials
EPRENETAPOPTSmall moleculemelanomaCellular tumor antigen p53 stabiliser1.0TerminatedClinicalTrials
CONTUSUGENE LADENOVECGenelung cancerCellular tumor antigen p53 positive modulator1.0CompletedClinicalTrials
NAVTEMADLINSmall moleculepolycythemia veraTumour suppressor p53/oncoprotein Mdm2 inhibitor2.0RecruitingClinicalTrials
CONTUSUGENE LADENOVECGenebreast cancerCellular tumor antigen p53 positive modulator1.0CompletedClinicalTrials
SIREMADLINSmall moleculemyelofibrosisTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0Active, not recruitingClinicalTrials
APG115Small moleculechronic myelomonocytic leukemiaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
IDASANUTLINSmall moleculeneoplasmTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0CompletedClinicalTrials
NAVTEMADLINSmall moleculemyelofibrosisTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
APG115Small moleculelymphoid leukemiaTumour suppressor p53/oncoprotein Mdm2 inhibitor2.0RecruitingClinicalTrials
SIREMADLINSmall moleculeneoplasmTumour suppressor p53/oncoprotein Mdm2 inhibitor2.0RecruitingClinicalTrials
APG115Small moleculeliposarcomaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
EPRENETAPOPTSmall moleculeovarian cancerCellular tumor antigen p53 stabiliser2.0CompletedClinicalTrials
SIREMADLINSmall moleculesoft tissue sarcomaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
SIREMADLINSmall moleculeacute myeloid leukemiaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
IDASANUTLINSmall moleculeacute myeloid leukemiaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0CompletedClinicalTrials
IDASANUTLINSmall moleculeglioblastoma multiformeTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
CONTUSUGENE LADENOVECGeneovarian cancerCellular tumor antigen p53 positive modulator1.0CompletedClinicalTrials
NAVTEMADLINSmall moleculetherapy related acute myeloid leukemia and myelodysplastic syndromeTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0SuspendedClinicalTrials
EPRENETAPOPTSmall moleculemyelodysplastic syndromeCellular tumor antigen p53 stabiliser3.0CompletedClinicalTrials
SIREMADLINSmall moleculeacute myeloid leukemiaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0WithdrawnClinicalTrials
APG115Small moleculeacute myeloid leukemiaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
CONTUSUGENE LADENOVECGeneurinary bladder carcinomaCellular tumor antigen p53 positive modulator1.0CompletedClinicalTrials
NAVTEMADLINSmall moleculemyeloproliferative disorderTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
NAVTEMADLINSmall moleculeMerkel cell skin cancerTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
CENERSENOligonucleotideacute myeloid leukemiap53 mRNA antisense inhibitor2.0CompletedClinicalTrials
IDASANUTLINSmall moleculeneoplasmTumour suppressor p53/oncoprotein Mdm2 inhibitor2.0RecruitingClinicalTrials
SIREMADLINSmall moleculeacute myeloid leukemiaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0Not yet recruitingClinicalTrials
NAVTEMADLINSmall moleculechronic myelogenous leukemiaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
CENERSEN SODIUMOligonucleotidechronic lymphocytic leukemiap53 mRNA antisense inhibitor2.0TerminatedClinicalTrials
NAVTEMADLINSmall moleculetherapy related acute myeloid leukemia and myelodysplastic syndromeTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
NAVTEMADLINSmall moleculeplasmacytomaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
IDASANUTLINSmall moleculefollicular lymphomaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0TerminatedClinicalTrials
CONTUSUGENE LADENOVECGenebreast cancerCellular tumor antigen p53 positive modulator2.0CompletedClinicalTrials
NAVTEMADLINSmall moleculegliosarcomaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0SuspendedClinicalTrials
SIREMADLINSmall moleculeliposarcomaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0CompletedClinicalTrials
SIREMADLINSmall moleculeneoplasmTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0CompletedClinicalTrials
IDASANUTLINSmall moleculepolycythemia veraTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0CompletedClinicalTrials
NAVTEMADLINSmall moleculeprimary myelofibrosisTumour suppressor p53/oncoprotein Mdm2 inhibitor2.0RecruitingClinicalTrials
CENERSENOligonucleotideacute myeloid leukemiap53 mRNA antisense inhibitor2.0WithdrawnClinicalTrials
CONTUSUGENE LADENOVECGenenon-small cell lung carcinomaCellular tumor antigen p53 positive modulator2.0Unknown statusClinicalTrials
CONTUSUGENE LADENOVECGenehead and neck malignant neoplasiaCellular tumor antigen p53 positive modulator2.0Unknown statusClinicalTrials
CONTUSUGENE LADENOVECGeneCentral Nervous System NeoplasmCellular tumor antigen p53 positive modulator1.0CompletedClinicalTrials
CONTUSUGENE LADENOVECGeneneoplasmCellular tumor antigen p53 positive modulator4.0Unknown statusClinicalTrials
CONTUSUGENE LADENOVECGeneperitoneum cancerCellular tumor antigen p53 positive modulator1.0CompletedClinicalTrials
APG115Small moleculesalivary gland cancerTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
NAVTEMADLINSmall moleculeacute myeloid leukemiaTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0RecruitingClinicalTrials
SIREMADLINSmall moleculeliver diseaseTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0Not yet recruitingClinicalTrials
CONTUSUGENE LADENOVECGenehead and neck malignant neoplasiaCellular tumor antigen p53 positive modulator2.0TerminatedClinicalTrials
NAVTEMADLINSmall moleculepolycythemia veraTumour suppressor p53/oncoprotein Mdm2 inhibitor2.0Active, not recruitingClinicalTrials
EPRENETAPOPTSmall moleculeovarian cancerCellular tumor antigen p53 stabiliser1.0CompletedClinicalTrials
NAVTEMADLINSmall moleculecancerTumour suppressor p53/oncoprotein Mdm2 inhibitor1.0CompletedClinicalTrials
CENERSENOligonucleotidemyelodysplastic syndromep53 mRNA antisense inhibitor1.0TerminatedClinicalTrials