Drugs target to TP53

Drug name Drug type Disease/phenotype Mechanism of action(MoA) Phase Status Source
CENERSENOligonucleotidenonep53 mRNA antisense inhibitor2['Terminated', 'Withdrawn', 'Completed']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
SIREMADLINSmall moleculenoneTumour suppressor p53/oncoprotein Mdm2 inhibitor2['Recruiting', 'Active, not recruiting', 'Withdrawn', 'Recruiting', 'Not yet recruiting', 'Completed', 'Completed', 'Terminated', 'Not yet recruiting', 'Terminated', 'Recruiting']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
NAVTEMADLINSmall moleculenoneTumour suppressor p53/oncoprotein Mdm2 inhibitor2['Recruiting', 'Active, not recruiting', 'Recruiting', 'Completed', 'Recruiting', 'Recruiting', 'Recruiting', 'Recruiting', 'Recruiting', 'Completed', 'Active, not recruiting', 'Recruiting', 'Suspended', 'Recruiting', 'Recruiting', 'Completed', 'Recruiting', 'Recruiting', 'Suspended']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
EPRENETAPOPTSmall moleculenoneCellular tumor antigen p53 stabiliser3['Completed', 'Completed', 'Completed', 'Completed', 'Terminated', 'Withdrawn', 'Terminated']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
APG115Small moleculenoneTumour suppressor p53/oncoprotein Mdm2 inhibitor2['Recruiting', 'Recruiting', 'Recruiting', 'Completed', 'Recruiting', 'Recruiting', 'Recruiting']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
IDASANUTLINSmall moleculenoneTumour suppressor p53/oncoprotein Mdm2 inhibitor3['Terminated', 'Terminated', 'Terminated', 'Active, not recruiting', 'Terminated', 'Completed', 'Terminated', 'Terminated', 'Terminated', 'Recruiting', 'Completed', 'Terminated', 'Completed', 'Completed', 'Recruiting']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
CONTUSUGENE LADENOVECGenenoneCellular tumor antigen p53 positive modulator4['Completed', 'Unknown status', 'Terminated', 'Unknown status', 'Completed', 'Completed', 'Unknown status', 'Completed', 'Completed', 'Terminated', 'Completed', 'Completed']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
CENERSEN SODIUMOligonucleotidenonep53 mRNA antisense inhibitor2['Terminated']['ClinicalTrials']
TEPRASIRANOligonucleotidenonep53 mRNA RNAi inhibitor2['Terminated', 'Completed']['ClinicalTrials', 'ClinicalTrials']