Ensembl ID ENSG00000276180 Gene ID 8294 Accession 4793
Gene Symbol H4C9 Alias H4M;H4/m;H4C1;H4C2;H4C3;H4C4;H4C5;H4C6;H4C8;H4FM;H4-16;H4C11;H4C12;H4C13;H4C14;H4C15;H4C16;HIST1H4I;TEVANED4;TEBIVANED4 Full Name H4 clustered histone 9
Position 6 : 27139282 - 27139678 Length 397 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

ENSG00000276180 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000276180 1.13 9.02e-17 KIRC
ENSG00000276180 1.65 1.24e-23 HNSC
ENSG00000276180 2.00 1.10e-12 BLCA
ENSG00000276180 2.03 1.65e-76 BRCA
ENSG00000276180 1.18 2.20e-14 LUSC
ENSG00000276180 0.87 7.94e-14 PRAD
ENSG00000276180 1.28 6.80e-11 KIRP
ENSG00000276180 1.02 1.53e-11 LIHC
ENSG00000276180 1.32 1.02e-23 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000276180 tumors 10344733
ENSG00000276180 tumour 10376979
ENSG00000276180 breast cancer 11682064
ENSG00000276180 Skin tumors 11782361
ENSG00000276180 tumor 12385581
ENSG00000276180 tumor 12579268
ENSG00000276180 gastric cancer 12677198
ENSG00000276180 colorectal cancers 12724227
ENSG00000276180 cancer 12865631
ENSG00000276180 Tumor 12891711
ENSG00000276180 tumor 12939461
ENSG00000276180 colon cancer 12975486
ENSG00000276180 tumours 14614037
ENSG00000276180 cancer 15095300
ENSG00000276180 cancer 15765097
ENSG00000276180 cancer 16131487
ENSG00000276180 tumors 16205112
ENSG00000276180 tumor 16254189
ENSG00000276180 tumors 16270534
ENSG00000276180 breast cancer 16322686
ENSG00000276180 tumours 16404435
ENSG00000276180 tumor 1644858
ENSG00000276180 tumor 16488987
ENSG00000276180 liver tumors 16497704
ENSG00000276180 cancer 16699174
ENSG00000276180 breast cancer 16707467
ENSG00000276180 breast cancer 16861913
ENSG00000276180 tumor 16863736
ENSG00000276180 tumor 1711413
ENSG00000276180 pediatric tumors 17725108
ENSG00000276180 cancer 17729398
ENSG00000276180 lung cancer 18172270
ENSG00000276180 tumor 18187659
ENSG00000276180 tumour 18384290
ENSG00000276180 cancer 18595135
ENSG00000276180 cancers 18701507
ENSG00000276180 cancer 18974389
ENSG00000276180 cancer 19056850
ENSG00000276180 tumor 19086847
ENSG00000276180 DLBCL 19438744
ENSG00000276180 cancer 19509260
ENSG00000276180 pancreatic cancer 19582723
ENSG00000276180 cancer 19961487
ENSG00000276180 ovarian epithelial tumors 20057286
ENSG00000276180 ovarian cancer 20111712
ENSG00000276180 tumor 20534538
ENSG00000276180 cancer 21145737
ENSG00000276180 breast cancers 21321083
ENSG00000276180 ovarian cancer 21355783
ENSG00000276180 cancer 21415707
ENSG00000276180 AML 21968610
ENSG00000276180 cancer 22035019
ENSG00000276180 cancer 22260708
ENSG00000276180 tumor 22279574
ENSG00000276180 cancer 22419068
ENSG00000276180 tumours 22569052
ENSG00000276180 pancreatic cancer 22607671
ENSG00000276180 tumor 22720237
ENSG00000276180 tumor 23019525
ENSG00000276180 tumor 23308215
ENSG00000276180 prostate cancer 23524101
ENSG00000276180 tumor 23553687
ENSG00000276180 tumor 23720754
ENSG00000276180 cancer 23826629
ENSG00000276180 prostate cancer 24065480
ENSG00000276180 thyroid cancer 24155971
ENSG00000276180 lung cancer 24283195
ENSG00000276180 tumor 24778322
ENSG00000276180 cancer 24913909
ENSG00000276180 prostate cancer 24937452
ENSG00000276180 cancers 24953066
ENSG00000276180 tumor 25073158
ENSG00000276180 pancreatic cancer 25152840
ENSG00000276180 colon cancer 25451013
ENSG00000276180 non-small-cell lung cancer 25473433
ENSG00000276180 tumors 25512468
ENSG00000276180 cancers 25512710
ENSG00000276180 breast tumors 25814362
ENSG00000276180 tumour 25864732
ENSG00000276180 tumors 25889518
ENSG00000276180 tumor 25954275
ENSG00000276180 Endometrial Cancer 26222483
ENSG00000276180 cancers 26321891
ENSG00000276180 tumors 26929985
ENSG00000276180 lung cancer 27091080
ENSG00000276180 prostate cancer 27268279
ENSG00000276180 cancer 27322556
ENSG00000276180 cancer 27499010
ENSG00000276180 cancer 27994746
ENSG00000276180 cancer 28139737
ENSG00000276180 tumor 28360947
ENSG00000276180 Prostate Cancer 28609657
ENSG00000276180 tumors 28866885
ENSG00000276180 cancer 28874504
ENSG00000276180 lung cancer 29030587
ENSG00000276180 prostate cancer 29069764
ENSG00000276180 cervical cancer 29184082
ENSG00000276180 tumor 29250163
ENSG00000276180 tumor 29308302
ENSG00000276180 cancer 29401749
ENSG00000276180 cancer 29616094
ENSG00000276180 breast cancer 29667342
ENSG00000276180 cancers 29721093
ENSG00000276180 breast cancer 29745061
ENSG00000276180 breast cancer 29759486
ENSG00000276180 tumor 30021196
ENSG00000276180 cancer 30394813
ENSG00000276180 cervical cancer 30416981
ENSG00000276180 cancer 30471193
ENSG00000276180 ovarian cancer 30759370
ENSG00000276180 cancer 30807115
ENSG00000276180 AML 30819918
ENSG00000276180 childhood cancer 30929275
ENSG00000276180 breast tumors 30938887
ENSG00000276180 pancreatic cancer 30942624
ENSG00000276180 tumour 31043582
ENSG00000276180 prostate cancer 31061526
ENSG00000276180 tumors 31137727
ENSG00000276180 bladder cancer 31217782
ENSG00000276180 breast cancer 31219579
ENSG00000276180 cancer 31312365
ENSG00000276180 Colon Cancer 31471419
ENSG00000276180 Cancer 31575549
ENSG00000276180 tumors 31608230
ENSG00000276180 tumor 31665067
ENSG00000276180 lung cancer 31737580
ENSG00000276180 cancer 31903140
ENSG00000276180 pituitary tumor 8232763
ENSG00000276180 tumors 8668193
ENSG00000276180 tumor 8816806
ENSG00000276180 tumor 9472111
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000276180 colorectal adenocarcinoma sequence_alteration 0.3518% (4/1137) 1 entry
ENSG00000276180 colon adenocarcinoma missense_variant 0.561% (4/713) 1 entry
ENSG00000276180 diffuse large B-cell lymphoma missense_variant 0.9901% (3/303) 2 entries
ENSG00000276180 gastric intestinal type adenocarcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000276180 diffuse large B-cell lymphoma frameshift_variant 0.9901% (3/303) 1 entry
ENSG00000276180 female breast carcinoma missense_variant 0.7491% (2/267) 1 entry
ENSG00000276180 pancreatic ductal adenocarcinoma missense_variant 0.1616% (2/1238) 1 entry
ENSG00000276180 skin melanoma missense_variant 0.1034% (1/967) 1 entry
ENSG00000276180 Central Nervous System Lymphoma missense_variant 11.11% (1/9) 1 entry
ENSG00000276180 Ampulla of Vater Carcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000276180 small cell lung carcinoma missense_variant 0.3155% (1/317) 1 entry
ENSG00000276180 brain glioblastoma missense_variant 0.1104% (1/906) 1 entry
ENSG00000276180 nasopharyngeal squamous cell carcinoma missense_variant 0.5988% (1/167) 1 entry
ENSG00000276180 lung adenocarcinoma stop_gained 0.3439% (4/1163) 1 entry
ENSG00000276180 basal cell carcinoma missense_variant 1.724% (1/58) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000276180 CHOL 0.031 low
ENSG00000276180 PAAD 0.00017 high
ENSG00000276180 UCEC 0.013 high
ENSG00000276180 THCA 0.03 high
ENSG00000276180 LUSC 0.026 low
ENSG00000276180 READ 0.014 high
ENSG00000276180 LUAD 0.001 high
ENSG00000276180 PCPG 0.00034 low
ENSG00000276180 THYM 0.0031 low
ENSG00000276180 BRCA 0.025 low
ENSG00000276180 COAD 0.003 high
ENSG00000276180 OV 0.0045 low
ENSG00000276180 KIRC 0.0044 high
ENSG00000276180 BLCA 0.035 low
ENSG00000276180 SKCM 0.00013 high
ENSG00000276180 CESC 0.00062 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000276180 ESCA Del 0.747354 0.098262 0.369911 0.271739
ENSG00000276180 SKCM Amp 2.263882 0.168955 0.745280 0.520436
ENSG00000276180 LIHC Amp 0.751287 0.113261 0.740006 0.394595
ENSG00000276180 BLCA Amp 2.132731 0.213624 0.545585 0.284314
ENSG00000276180 UVM Amp 1.976306 0.243776 1.129589 0.537500
ENSG00000276180 OV Amp 2.210006 0.380700 0.705937 0.469775