Ensembl ID ENSG00000262814 Gene ID 6182 Accession 10378
Gene Symbol MRPL12 Alias 5c5-2;L12mt;MRPL7;bL12m;RPML12;MRPL7/L12;MRP-L31/34 Full Name mitochondrial ribosomal protein L12
Position 17 : 81703367 - 81707517 Length 4151 bases Strand Plus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]

ENSG00000262814 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000262814 MRPL12 1.45 4.06e-37 BRCA
ENSG00000262814 MRPL12 1.69 7.60e-52 LUSC
ENSG00000262814 MRPL12 0.97 1.16e-12 PRAD
ENSG00000262814 MRPL12 1.55 3.67e-18 UCEC
ENSG00000262814 MRPL12 1.22 5.90e-23 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000262814 MRPL12 tumor 19753307
ENSG00000262814 MRPL12 GBM 26781422
ENSG00000262814 MRPL12 breast cancer 27720940
ENSG00000262814 MRPL12 tumor 9169145
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000262814 MRPL12 MESO 0.048 high
ENSG00000262814 MRPL12 STAD 0.027 low
ENSG00000262814 MRPL12 CHOL 0.035 high
ENSG00000262814 MRPL12 UVM 0.0036 high
ENSG00000262814 MRPL12 UCEC 0.031 high
ENSG00000262814 MRPL12 ACC 0.00092 high
ENSG00000262814 MRPL12 LUSC 0.033 high
ENSG00000262814 MRPL12 HNSC 0.034 high
ENSG00000262814 MRPL12 LUAD 0.0012 high
ENSG00000262814 MRPL12 PCPG 0.038 high
ENSG00000262814 MRPL12 COAD 0.044 low
ENSG00000262814 MRPL12 ESCA 0.0079 high
ENSG00000262814 MRPL12 OV 0.0069 low
ENSG00000262814 MRPL12 PRAD 0.037 high
ENSG00000262814 MRPL12 BLCA 0.045 low
ENSG00000262814 MRPL12 LAML 0.012 high
ENSG00000262814 MRPL12 SKCM 0.00038 high
ENSG00000262814 MRPL12 CESC 0.045 low
ENSG00000262814 MRPL12 LIHC 0.0057 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000262814 MRPL12 LUSC Amp 0.707560 0.193565 0.442531 0.427146
ENSG00000262814 MRPL12 LUAD Amp 3.288406 0.174615 0.402153 0.503876
ENSG00000262814 MRPL12 LGG Amp 2.997904 0.076454 0.499621 0.097466
ENSG00000262814 MRPL12 HNSC Del 1.188778 0.060147 0.357491 0.111111
ENSG00000262814 MRPL12 LIHC Amp 11.226461 0.306000 0.706407 0.378378
ENSG00000262814 MRPL12 BLCA Amp 2.173392 0.214794 0.469857 0.465686
ENSG00000262814 MRPL12 BRCA Amp 18.692276 0.339238 0.611410 0.361111
ENSG00000262814 MRPL12 UCEC Amp 6.833620 0.207663 0.620038 0.183673
ENSG00000262814 MRPL12 OV Amp 3.116015 0.406256 0.553763 0.364421