Ensembl ID ENSG00000256525 Gene ID 11232 Accession 9180
Gene Symbol POLG2 Alias HP55;POLB;PEOA4;POLGB;MTPOLB;MTDPS16;MTDPS16A;MTDPS16B;POLG-BETA Full Name DNA polymerase gamma 2, accessory subunit
Position 17 : 64477785 - 64497054 Length 19270 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.[provided by RefSeq, Sep 2009]

ENSG00000256525 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000256525 POLG2 1.09 2.98e-44 KIRC
ENSG00000256525 POLG2 0.91 3.72e-11 BLCA
ENSG00000256525 POLG2 0.86 2.69e-22 COAD
ENSG00000256525 POLG2 1.04 8.06e-11 READ
ENSG00000256525 POLG2 0.98 1.76e-26 LUSC
ENSG00000256525 POLG2 0.49 1.49e-12 PRAD
ENSG00000256525 POLG2 1.42 4.99e-25 KIRP
ENSG00000256525 POLG2 0.97 3.11e-27 LIHC
ENSG00000256525 POLG2 0.81 7.90e-16 STAD
ENSG00000256525 POLG2 1.23 1.60e-46 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000256525 POLG2 lung cancer 17494052
ENSG00000256525 POLG2 urinary bladder cancer 21734712
ENSG00000256525 POLG2 urinary bladder cancer 21753769
ENSG00000256525 POLG2 cancer 25294834
ENSG00000256525 POLG2 cancer 26403317
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000256525 POLG2 SARC 0.033 high
ENSG00000256525 POLG2 STAD 0.01 low
ENSG00000256525 POLG2 PAAD 0.0038 low
ENSG00000256525 POLG2 UCEC 0.032 low
ENSG00000256525 POLG2 ACC 0.0052 high
ENSG00000256525 POLG2 LGG 0.0031 high
ENSG00000256525 POLG2 HNSC 0.0075 high
ENSG00000256525 POLG2 READ 0.00033 low
ENSG00000256525 POLG2 KICH 0.0045 high
ENSG00000256525 POLG2 LUAD 0.039 high
ENSG00000256525 POLG2 PCPG 0.00012 high
ENSG00000256525 POLG2 THYM 0.0024 low
ENSG00000256525 POLG2 PRAD 0.0071 high
ENSG00000256525 POLG2 BLCA 0.0018 low
ENSG00000256525 POLG2 GBM 0.035 low
ENSG00000256525 POLG2 SKCM 0.0048 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000256525 POLG2 LUSC Amp 0.701353 0.193414 0.438799 0.451098
ENSG00000256525 POLG2 PAAD Del 3.993469 0.104146 0.373082 0.222826
ENSG00000256525 POLG2 SKCM Amp 4.812877 0.237699 0.554642 0.335150
ENSG00000256525 POLG2 LIHC Amp 5.395962 0.214253 0.653107 0.359459
ENSG00000256525 POLG2 BLCA Amp 3.341638 0.248825 0.508191 0.473039
ENSG00000256525 POLG2 BRCA Amp 51.279088 0.556429 0.840394 0.394444
ENSG00000256525 POLG2 UCEC Amp 0.820943 0.106086 0.576775 0.124304
ENSG00000256525 POLG2 UVM Amp 0.721460 0.165534 0.811066 0.162500