Ensembl ID
ENSG00000256525
Gene ID
11232
Accession
9180
Gene Symbol
POLG2
Alias
HP55;POLB;PEOA4;POLGB;MTPOLB;MTDPS16;MTDPS16A;MTDPS16B;POLG-BETA
Full Name
DNA polymerase gamma 2, accessory subunit
Position
17 : 64477785 - 64497054
Length
19270 bases
Strand
Minus strand
Status
Confidence
Main interacting RNAs N.A. RBP type
Canonical_RBPs
Summary
This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.[provided by RefSeq, Sep 2009]
ENSG00000256525 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000256525
1.09
2.98e-44
KIRC
ENSG00000256525
0.91
3.72e-11
BLCA
ENSG00000256525
0.86
2.69e-22
COAD
ENSG00000256525
1.04
8.06e-11
READ
ENSG00000256525
0.98
1.76e-26
LUSC
ENSG00000256525
0.49
1.49e-12
PRAD
ENSG00000256525
1.42
4.99e-25
KIRP
ENSG00000256525
0.97
3.11e-27
LIHC
ENSG00000256525
0.81
7.90e-16
STAD
ENSG00000256525
1.23
1.60e-46
LUAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000256525
lung cancer
17494052
ENSG00000256525
urinary bladder cancer
21734712
ENSG00000256525
urinary bladder cancer
21753769
ENSG00000256525
cancer
25294834
ENSG00000256525
cancer
26403317
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000256525
SARC
0.033
high
show
ENSG00000256525
STAD
0.01
low
show
ENSG00000256525
PAAD
0.0038
low
show
ENSG00000256525
UCEC
0.032
low
show
ENSG00000256525
ACC
0.0052
high
show
ENSG00000256525
LGG
0.0031
high
show
ENSG00000256525
HNSC
0.0075
high
show
ENSG00000256525
READ
0.00033
low
show
ENSG00000256525
KICH
0.0045
high
show
ENSG00000256525
LUAD
0.039
high
show
ENSG00000256525
PCPG
0.00012
high
show
ENSG00000256525
THYM
0.0024
low
show
ENSG00000256525
PRAD
0.0071
high
show
ENSG00000256525
BLCA
0.0018
low
show
ENSG00000256525
GBM
0.035
low
show
ENSG00000256525
SKCM
0.0048
low
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000256525
LUSC
Amp
0.701353
0.193414
0.438799
0.451098
ENSG00000256525
PAAD
Del
3.993469
0.104146
0.373082
0.222826
ENSG00000256525
SKCM
Amp
4.812877
0.237699
0.554642
0.335150
ENSG00000256525
LIHC
Amp
5.395962
0.214253
0.653107
0.359459
ENSG00000256525
BLCA
Amp
3.341638
0.248825
0.508191
0.473039
ENSG00000256525
BRCA
Amp
51.279088
0.556429
0.840394
0.394444
ENSG00000256525
UCEC
Amp
0.820943
0.106086
0.576775
0.124304
ENSG00000256525
UVM
Amp
0.721460
0.165534
0.811066
0.162500
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