Ensembl ID ENSG00000243927 Gene ID 64968 Accession 14051
Gene Symbol MRPS6 Alias S6mt;bS6m;RPMS6;MRP-S6;C21orf101 Full Name mitochondrial ribosomal protein S6
Position 21 : 34073578 - 34143030 Length 69453 bases Strand Plus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]

ENSG00000243927 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000243927 MRPS6 -1.5 7.08e-41 KIRC
ENSG00000243927 MRPS6 -1.3 4.82e-14 KICH
ENSG00000243927 MRPS6 -2.2 2.08e-77 KIRP
ENSG00000243927 MRPS6 0.72 6.45e-12 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000243927 MRPS6 SARC 0.0044 high
ENSG00000243927 MRPS6 STAD 0.029 high
ENSG00000243927 MRPS6 ACC 0.00032 high
ENSG00000243927 MRPS6 HNSC 0.041 high
ENSG00000243927 MRPS6 READ 0.0096 low
ENSG00000243927 MRPS6 LUAD 0.024 low
ENSG00000243927 MRPS6 THYM 0.002 low
ENSG00000243927 MRPS6 BRCA 0.034 high
ENSG00000243927 MRPS6 UCS 0.0079 low
ENSG00000243927 MRPS6 ESCA 0.014 high
ENSG00000243927 MRPS6 OV 0.0021 low
ENSG00000243927 MRPS6 KIRC 0.00081 high
ENSG00000243927 MRPS6 TGCT 0.05 low
ENSG00000243927 MRPS6 GBM 0.0071 high
ENSG00000243927 MRPS6 SKCM 0.00015 low
ENSG00000243927 MRPS6 CESC 0.022 low
ENSG00000243927 MRPS6 LIHC 0.0075 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency