Ensembl ID ENSG00000242372 Gene ID 3692 Accession 6159
Gene Symbol EIF6 Alias CAB;EIF3A;eIF-6;p27BBP;ITGB4BP;b(2)gcn;p27(BBP) Full Name eukaryotic translation initiation factor 6
Position 20 : 35278907 - 35284985 Length 6079 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Non-canonical_RBPs
Summary Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

ENSG00000242372 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000242372 EIF6 0.84 6.80e-36 BRCA
ENSG00000242372 EIF6 1.07 4.95e-34 LUSC
ENSG00000242372 EIF6 0.80 2.37e-12 UCEC
ENSG00000242372 EIF6 0.78 1.15e-19 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000242372 EIF6 tumor 12733146
ENSG00000242372 EIF6 tumor 15122657
ENSG00000242372 EIF6 colon cancer 17667944
ENSG00000242372 EIF6 tumours 18442408
ENSG00000242372 EIF6 gastric cancer 20331625
ENSG00000242372 EIF6 non-small cell lung cancer 21029697
ENSG00000242372 EIF6 tumor 21665150
ENSG00000242372 EIF6 cancer 22031223
ENSG00000242372 EIF6 ovarian cancer 22348144
ENSG00000242372 EIF6 tumor 22365962
ENSG00000242372 EIF6 AML 24330778
ENSG00000242372 EIF6 breast cancer 24970821
ENSG00000242372 EIF6 tumors 25151356
ENSG00000242372 EIF6 tumor 25252159
ENSG00000242372 EIF6 cancer 25886394
ENSG00000242372 EIF6 cancer 26383020
ENSG00000242372 EIF6 tumors 26462016
ENSG00000242372 EIF6 tumor 27913676
ENSG00000242372 EIF6 cancer 28693127
ENSG00000242372 EIF6 tumor 28743432
ENSG00000242372 EIF6 tumor 29153483
ENSG00000242372 EIF6 rectum cancer 29254159
ENSG00000242372 EIF6 non-small cell lung cancer 30077122
ENSG00000242372 EIF6 AML 30585299
ENSG00000242372 EIF6 tumour 30781559
ENSG00000242372 EIF6 Colorectal Cancer 31196358
ENSG00000242372 EIF6 cancers 31411736
ENSG00000242372 EIF6 gallbladder cancer 31586263
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000242372 EIF6 MESO 0.00096 high
ENSG00000242372 EIF6 SARC 0.014 high
ENSG00000242372 EIF6 CHOL 0.0086 high
ENSG00000242372 EIF6 PAAD 0.0053 high
ENSG00000242372 EIF6 ACC 0.015 high
ENSG00000242372 EIF6 LGG 0.00025 high
ENSG00000242372 EIF6 LUAD 0.00023 high
ENSG00000242372 EIF6 PCPG 0.023 low
ENSG00000242372 EIF6 BRCA 0.049 low
ENSG00000242372 EIF6 ESCA 0.0074 high
ENSG00000242372 EIF6 KIRC 0.018 high
ENSG00000242372 EIF6 LAML 0.0093 high
ENSG00000242372 EIF6 GBM 0.034 high
ENSG00000242372 EIF6 SKCM 0.0016 high
ENSG00000242372 EIF6 LIHC 1e-04 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000242372 EIF6 CESC Amp 1.620042 0.164685 0.671442 0.437288
ENSG00000242372 EIF6 READ Amp 18.761879 0.643688 1.298846 0.884848
ENSG00000242372 EIF6 COAD Amp 33.124518 0.439254 1.147311 0.720621
ENSG00000242372 EIF6 HNSC Amp 0.676902 0.114763 0.540628 0.423372
ENSG00000242372 EIF6 BRCA Amp 1.529626 0.161929 0.577212 0.434259