Ensembl ID ENSG00000242265 Gene ID 23089 Accession 14005
Gene Symbol PEG10 Alias EDR;HB-1;Mar2;RTL2;MEF3L;Mart2;RGAG3;SIRH1 Full Name paternally expressed 10
Position 7 : 94656325 - 94669695 Length 13371 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]

ENSG00000242265 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000242265 PEG10 -2.4 6.97e-13 KICH
ENSG00000242265 PEG10 4.56 9.25e-27 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000242265 PEG10 cancer 16423995
ENSG00000242265 PEG10 tumors 17126992
ENSG00000242265 PEG10 hepatic cancer 17369855
ENSG00000242265 PEG10 cancer 18251374
ENSG00000242265 PEG10 cancer 18625225
ENSG00000242265 PEG10 tumor 19567027
ENSG00000242265 PEG10 tumors 20362226
ENSG00000242265 PEG10 liver cancer 21205473
ENSG00000242265 PEG10 tumor 21352943
ENSG00000242265 PEG10 tumor 21455631
ENSG00000242265 PEG10 tumor 21767414
ENSG00000242265 PEG10 tumor 22673314
ENSG00000242265 PEG10 breast cancer 24128438
ENSG00000242265 PEG10 tumor 24373183
ENSG00000242265 PEG10 tumor 24944680
ENSG00000242265 PEG10 lung cancer 25199998
ENSG00000242265 PEG10 esophageal cancer 25591808
ENSG00000242265 PEG10 Tumor 25687862
ENSG00000242265 PEG10 Prostate Cancer 26235627
ENSG00000242265 PEG10 cancer 26256205
ENSG00000242265 PEG10 lung cancer 26934961
ENSG00000242265 PEG10 cancer 27144335
ENSG00000242265 PEG10 cancer 27265324
ENSG00000242265 PEG10 tumor 27370270
ENSG00000242265 PEG10 tumors 28004118
ENSG00000242265 PEG10 cancers 28098215
ENSG00000242265 PEG10 tumors 28166733
ENSG00000242265 PEG10 pancreatic cancer 28193232
ENSG00000242265 PEG10 esophageal cancer 28388588
ENSG00000242265 PEG10 tumor 28669160
ENSG00000242265 PEG10 tumor 28928830
ENSG00000242265 PEG10 tumour 29044189
ENSG00000242265 PEG10 cancer 29058812
ENSG00000242265 PEG10 gastric cancer 29088808
ENSG00000242265 PEG10 cancer 29245927
ENSG00000242265 PEG10 prostate cancer 29396873
ENSG00000242265 PEG10 DLBCL 29665941
ENSG00000242265 PEG10 tumors 29727698
ENSG00000242265 PEG10 breast cancer 29765553
ENSG00000242265 PEG10 tumor 29900883
ENSG00000242265 PEG10 tumor 29940767
ENSG00000242265 PEG10 DLBCL 29963159
ENSG00000242265 PEG10 bone tumors 30094509
ENSG00000242265 PEG10 tumor 30123090
ENSG00000242265 PEG10 tumour 30450735
ENSG00000242265 PEG10 bladder cancer 30941768
ENSG00000242265 PEG10 bladder cancer 30953817
ENSG00000242265 PEG10 prostate cancer 31013476
ENSG00000242265 PEG10 bladder cancer 31053526
ENSG00000242265 PEG10 cancers 31241046
ENSG00000242265 PEG10 Prostate Cancer 31530569
ENSG00000242265 PEG10 cancers 31702614
ENSG00000242265 PEG10 tumor 8267387
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000242265 PEG10 MESO 0.0067 high
ENSG00000242265 PEG10 SARC 0.0084 high
ENSG00000242265 PEG10 STAD 0.0073 high
ENSG00000242265 PEG10 UVM 0.013 low
ENSG00000242265 PEG10 PAAD 0.00054 low
ENSG00000242265 PEG10 UCEC 7e-04 low
ENSG00000242265 PEG10 THCA 0.046 high
ENSG00000242265 PEG10 LUSC 0.031 low
ENSG00000242265 PEG10 HNSC 0.0049 high
ENSG00000242265 PEG10 LUAD 0.0096 low
ENSG00000242265 PEG10 PCPG 0.023 low
ENSG00000242265 PEG10 THYM 0.036 high
ENSG00000242265 PEG10 OV 0.034 low
ENSG00000242265 PEG10 KIRC 0.0033 low
ENSG00000242265 PEG10 BLCA 0.017 high
ENSG00000242265 PEG10 LAML 0.04 high
ENSG00000242265 PEG10 SKCM 0.0072 low
ENSG00000242265 PEG10 CESC 0.021 high
ENSG00000242265 PEG10 LIHC 0.0083 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000242265 PEG10 LUSC Amp 1.263290 0.213298 0.526573 0.518962
ENSG00000242265 PEG10 KIRP Amp 0.728981 0.053479 0.911594 0.607639
ENSG00000242265 PEG10 GBM Amp 0.744662 0.067724 0.785688 0.824957
ENSG00000242265 PEG10 ESCA Amp 10.399468 0.679591 0.807887 0.603261
ENSG00000242265 PEG10 HNSC Amp 7.643952 0.244595 0.638143 0.318008
ENSG00000242265 PEG10 LIHC Amp 0.933876 0.118878 0.616973 0.332432
ENSG00000242265 PEG10 TGCT Amp 0.894702 0.127154 0.523108 0.766667
ENSG00000242265 PEG10 STAD Amp 9.276902 0.316005 0.636354 0.446712
ENSG00000242265 PEG10 PRAD Amp 0.736647 0.046252 0.500519 0.207317