Ensembl ID ENSG00000215301 Gene ID 1654 Accession 2745
Gene Symbol DDX3X Alias DBX;DDX3;HLP2;DDX14;CAP-Rf;MRX102;MRXSSB Full Name DEAD-box helicase 3 X-linked
Position X : 41333348 - 41364472 Length 31125 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

ENSG00000215301 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000215301 DDX3X -0.9 2.29e-14 BLCA
ENSG00000215301 DDX3X -0.5 2.02e-39 BRCA
ENSG00000215301 DDX3X -0.4 2.08e-12 LUSC
ENSG00000215301 DDX3X -0.7 3.34e-24 LIHC
ENSG00000215301 DDX3X -0.4 5.56e-15 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000215301 DDX3X tumor 16818630
ENSG00000215301 DDX3X tumor 17667941
ENSG00000215301 DDX3X tumors 17962616
ENSG00000215301 DDX3X breast cancer 18264132
ENSG00000215301 DDX3X cancers 18628297
ENSG00000215301 DDX3X cancer 18846110
ENSG00000215301 DDX3X tumour 19793905
ENSG00000215301 DDX3X cancers 21237216
ENSG00000215301 DDX3X lung cancer 21325288
ENSG00000215301 DDX3X breast cancer 21448281
ENSG00000215301 DDX3X tumor 21589879
ENSG00000215301 DDX3X cancer 22034099
ENSG00000215301 DDX3X tumor 22340241
ENSG00000215301 DDX3X endometrial cancer 22492871
ENSG00000215301 DDX3X tumours 22722829
ENSG00000215301 DDX3X tumors 22820256
ENSG00000215301 DDX3X tumour 22832583
ENSG00000215301 DDX3X tumor 23108300
ENSG00000215301 DDX3X tumor 23330003
ENSG00000215301 DDX3X tumor 23410059
ENSG00000215301 DDX3X tumor 23584477
ENSG00000215301 DDX3X cancer 23606618
ENSG00000215301 DDX3X Breast Cancer 23696831
ENSG00000215301 DDX3X tumor 23974721
ENSG00000215301 DDX3X tumors 24608801
ENSG00000215301 DDX3X cancer 24748754
ENSG00000215301 DDX3X tumor 24965446
ENSG00000215301 DDX3X cancer 25043297
ENSG00000215301 DDX3X tumors 25056374
ENSG00000215301 DDX3X lung cancer 25343452
ENSG00000215301 DDX3X Tumor 25538732
ENSG00000215301 DDX3X Cancer 25724843
ENSG00000215301 DDX3X tumor 25820276
ENSG00000215301 DDX3X cancer 25867071
ENSG00000215301 DDX3X oral cancer 25918862
ENSG00000215301 DDX3X tumor 26087195
ENSG00000215301 DDX3X tumor 26184164
ENSG00000215301 DDX3X tumor 26192917
ENSG00000215301 DDX3X tumors 26294807
ENSG00000215301 DDX3X colorectal cancer 26311743
ENSG00000215301 DDX3X tumor 26337079
ENSG00000215301 DDX3X tumors 26352260
ENSG00000215301 DDX3X lung cancers 26364611
ENSG00000215301 DDX3X cancer 26541825
ENSG00000215301 DDX3X cancers 26650549
ENSG00000215301 DDX3X colorectal cancer 26892600
ENSG00000215301 DDX3X tumor 27007150
ENSG00000215301 DDX3X cancer 27058758
ENSG00000215301 DDX3X Cancer 27180681
ENSG00000215301 DDX3X cancer 27186411
ENSG00000215301 DDX3X liver cancer 27344963
ENSG00000215301 DDX3X cancer 27586307
ENSG00000215301 DDX3X Prostate Cancer 27634756
ENSG00000215301 DDX3X tumour 27736973
ENSG00000215301 DDX3X tumors 27869828
ENSG00000215301 DDX3X tumor 27999982
ENSG00000215301 DDX3X tumor 28128295
ENSG00000215301 DDX3X breast cancer 28138868
ENSG00000215301 DDX3X cancer 28246464
ENSG00000215301 DDX3X cancer 28402257
ENSG00000215301 DDX3X tumor 28435452
ENSG00000215301 DDX3X tumor 28442604
ENSG00000215301 DDX3X Colorectal cancers 28761359
ENSG00000215301 DDX3X tumour 28829764
ENSG00000215301 DDX3X colorectal cancer 28842590
ENSG00000215301 DDX3X breast cancer 28869602
ENSG00000215301 DDX3X cancer 29062139
ENSG00000215301 DDX3X cancer 29146961
ENSG00000215301 DDX3X cancer 29203243
ENSG00000215301 DDX3X tumors 29222110
ENSG00000215301 DDX3X cancer 29328432
ENSG00000215301 DDX3X colonic cancer 29383159
ENSG00000215301 DDX3X meningeal tumors 29621097
ENSG00000215301 DDX3X cancer 29684792
ENSG00000215301 DDX3X breast cancer 29782654
ENSG00000215301 DDX3X HNSCC 29921696
ENSG00000215301 DDX3X cancer 30123936
ENSG00000215301 DDX3X tumour 30131165
ENSG00000215301 DDX3X tumor 30134235
ENSG00000215301 DDX3X tumors 30171198
ENSG00000215301 DDX3X cancer 30256975
ENSG00000215301 DDX3X tumor 30292066
ENSG00000215301 DDX3X tumors 30546078
ENSG00000215301 DDX3X Cancer 30563889
ENSG00000215301 DDX3X tumor 30576442
ENSG00000215301 DDX3X tumor 30662610
ENSG00000215301 DDX3X tumor 30805320
ENSG00000215301 DDX3X cancer 30816053
ENSG00000215301 DDX3X tumors 30821613
ENSG00000215301 DDX3X cancer 30899416
ENSG00000215301 DDX3X Prostate Cancer 30926334
ENSG00000215301 DDX3X brain tumor 30936465
ENSG00000215301 DDX3X cancer 31141444
ENSG00000215301 DDX3X tumor 31204176
ENSG00000215301 DDX3X cancers 31216476
ENSG00000215301 DDX3X malignant tumor 31235588
ENSG00000215301 DDX3X cancer 31300642
ENSG00000215301 DDX3X tumor 31391454
ENSG00000215301 DDX3X cervical cancer 31568920
ENSG00000215301 DDX3X cancer 31690062
ENSG00000215301 DDX3X tumor 31870915
ENSG00000215301 DDX3X Cancer 31906196
ENSG00000215301 DDX3X cancer 31954521
ENSG00000215301 DDX3X tumors 7721611
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000215301 DDX3X central nervous system primitive neuroectodermal neoplasm sequence_alteration 7.522% (34/452) 1 entry
ENSG00000215301 DDX3X colorectal adenocarcinoma missense_variant 2.988% (34/1138) 3 entries
ENSG00000215301 DDX3X medulloblastoma missense_variant 29.17% (7/24) 1 entry
ENSG00000215301 DDX3X central nervous system primitive neuroectodermal neoplasm missense_variant 7.522% (34/452) 5 entries
ENSG00000215301 DDX3X colorectal adenocarcinoma stop_gained 2.988% (34/1138) 1 entry
ENSG00000215301 DDX3X colorectal adenocarcinoma sequence_alteration 2.988% (34/1138) 3 entries
ENSG00000215301 DDX3X prostate adenocarcinoma frameshift_variant 1.231% (18/1462) 1 entry
ENSG00000215301 DDX3X bronchoalveolar adenocarcinoma missense_variant 13.64% (3/22) 1 entry
ENSG00000215301 DDX3X chronic lymphocytic leukemia missense_variant 1.66% (17/1024) 1 entry
ENSG00000215301 DDX3X Pleural Epithelioid Mesothelioma missense_variant 5.063% (8/158) 2 entries
ENSG00000215301 DDX3X small cell lung carcinoma missense_variant 0.9434% (3/318) 2 entries
ENSG00000215301 DDX3X breast ductal adenocarcinoma missense_variant 2.593% (16/617) 3 entries
ENSG00000215301 DDX3X pharyngeal squamous cell carcinoma missense_variant 6.452% (2/31) 1 entry
ENSG00000215301 DDX3X squamous cell lung carcinoma missense_variant 1.05% (8/762) 1 entry
ENSG00000215301 DDX3X prostate adenocarcinoma missense_variant 1.231% (18/1462) 2 entries
ENSG00000215301 DDX3X small cell lung carcinoma sequence_alteration 0.9434% (3/318) 2 entries
ENSG00000215301 DDX3X medulloblastoma sequence_alteration 29.17% (7/24) 1 entry
ENSG00000215301 DDX3X squamous cell lung carcinoma sequence_alteration 1.05% (8/762) 2 entries
ENSG00000215301 DDX3X female breast carcinoma missense_variant 1.124% (3/267) 2 entries
ENSG00000215301 DDX3X T-cell acute lymphoblastic leukemia missense_variant 1.312% (5/381) 2 entries
ENSG00000215301 DDX3X skin melanoma missense_variant 2.068% (20/967) 3 entries
ENSG00000215301 DDX3X HER2 Positive Breast Carcinoma missense_variant 7.018% (8/114) 2 entries
ENSG00000215301 DDX3X diffuse large B-cell lymphoma missense_variant 2.288% (7/306) 3 entries
ENSG00000215301 DDX3X prostate carcinoma sequence_alteration 0.4695% (2/426) 1 entry
ENSG00000215301 DDX3X melanoma missense_variant 2.941% (3/102) 1 entry
ENSG00000215301 DDX3X prostate adenocarcinoma sequence_alteration 1.231% (18/1462) 2 entries
ENSG00000215301 DDX3X chronic lymphocytic leukemia sequence_alteration 1.66% (17/1024) 1 entry
ENSG00000215301 DDX3X head and neck squamous cell carcinoma frameshift_variant 0.8043% (6/746) 1 entry
ENSG00000215301 DDX3X malignant epithelioid mesothelioma missense_variant 16.67% (2/12) 1 entry
ENSG00000215301 DDX3X Pleural Epithelioid Mesothelioma stop_gained 5.063% (8/158) 1 entry
ENSG00000215301 DDX3X chronic lymphocytic leukemia frameshift_variant 1.66% (17/1024) 1 entry
ENSG00000215301 DDX3X colorectal adenocarcinoma frameshift_variant 2.988% (34/1138) 1 entry
ENSG00000215301 DDX3X nasopharyngeal squamous cell carcinoma sequence_alteration 1.796% (3/167) 1 entry
ENSG00000215301 DDX3X bladder transitional cell carcinoma missense_variant 2.92% (4/137) 2 entries
ENSG00000215301 DDX3X ovarian teratoma missense_variant 5.556% (3/54) 1 entry
ENSG00000215301 DDX3X head and neck squamous cell carcinoma sequence_alteration 0.8043% (6/746) 1 entry
ENSG00000215301 DDX3X esophageal squamous cell carcinoma sequence_alteration 1.625% (11/677) 2 entries
ENSG00000215301 DDX3X breast carcinoma missense_variant 0.7796% (11/1411) 1 entry
ENSG00000215301 DDX3X gastric intestinal type adenocarcinoma missense_variant 2.353% (2/85) 2 entries
ENSG00000215301 DDX3X esophageal squamous cell carcinoma frameshift_variant 1.625% (11/677) 3 entries
ENSG00000215301 DDX3X pancreatic ductal adenocarcinoma missense_variant 1.589% (20/1259) 2 entries
ENSG00000215301 DDX3X colon adenocarcinoma sequence_alteration 0.9472% (7/739) 2 entries
ENSG00000215301 DDX3X colon adenocarcinoma missense_variant 0.9472% (7/739) 5 entries
ENSG00000215301 DDX3X Pleural Epithelioid Mesothelioma sequence_alteration 5.063% (8/158) 1 entry
ENSG00000215301 DDX3X hepatocellular carcinoma sequence_alteration 0.6652% (6/902) 1 entry
ENSG00000215301 DDX3X head and neck squamous cell carcinoma missense_variant 0.8043% (6/746) 2 entries
ENSG00000215301 DDX3X esophageal squamous cell carcinoma missense_variant 1.625% (11/677) 2 entries
ENSG00000215301 DDX3X nasopharyngeal squamous cell carcinoma missense_variant 1.796% (3/167) 1 entry
ENSG00000215301 DDX3X lung adenocarcinoma missense_variant 1.376% (16/1163) 6 entries
ENSG00000215301 DDX3X lung adenocarcinoma sequence_alteration 1.376% (16/1163) 3 entries
ENSG00000215301 DDX3X bronchoalveolar adenocarcinoma sequence_alteration 13.64% (3/22) 1 entry
ENSG00000215301 DDX3X acute lymphoblastic leukemia missense_variant 0.6231% (2/321) 2 entries
ENSG00000215301 DDX3X chronic lymphocytic leukemia stop_gained 1.66% (17/1024) 1 entry
ENSG00000215301 DDX3X hairy cell leukemia missense_variant 4.762% (1/21) 1 entry
ENSG00000215301 DDX3X bladder transitional cell carcinoma stop_gained 2.92% (4/137) 1 entry
ENSG00000215301 DDX3X malignant epithelioid mesothelioma sequence_alteration 16.67% (2/12) 1 entry
ENSG00000215301 DDX3X papillary thyroid carcinoma missense_variant 0.2532% (1/395) 1 entry
ENSG00000215301 DDX3X Pleural Biphasic Mesothelioma missense_variant 1.449% (1/69) 1 entry
ENSG00000215301 DDX3X T-cell acute lymphoblastic leukemia sequence_alteration 1.312% (5/381) 1 entry
ENSG00000215301 DDX3X adenosquamous lung carcinoma missense_variant 9.091% (1/11) 1 entry
ENSG00000215301 DDX3X large cell medulloblastoma missense_variant 15.79% (3/19) 1 entry
ENSG00000215301 DDX3X lung adenocarcinoma frameshift_variant 1.376% (16/1163) 1 entry
ENSG00000215301 DDX3X cecum adenocarcinoma stop_gained 1.587% (2/126) 1 entry
ENSG00000215301 DDX3X breast ductal adenocarcinoma stop_gained 2.593% (16/617) 2 entries
ENSG00000215301 DDX3X laryngeal squamous cell carcinoma stop_lost 3.846% (1/26) 1 entry
ENSG00000215301 DDX3X laryngeal squamous cell carcinoma sequence_alteration 3.846% (1/26) 1 entry
ENSG00000215301 DDX3X squamous cell lung carcinoma stop_gained 1.05% (8/762) 1 entry
ENSG00000215301 DDX3X brain glioblastoma sequence_alteration 0.2157% (2/927) 1 entry
ENSG00000215301 DDX3X malignant epithelioid mesothelioma frameshift_variant 16.67% (2/12) 1 entry
ENSG00000215301 DDX3X bile duct adenocarcinoma missense_variant 0.5291% (1/189) 1 entry
ENSG00000215301 DDX3X small cell lung carcinoma frameshift_variant 0.9434% (3/318) 1 entry
ENSG00000215301 DDX3X skin melanoma frameshift_variant 2.068% (20/967) 1 entry
ENSG00000215301 DDX3X bladder transitional cell carcinoma sequence_alteration 2.92% (4/137) 1 entry
ENSG00000215301 DDX3X ovarian serous adenocarcinoma missense_variant 0.1486% (1/673) 1 entry
ENSG00000215301 DDX3X Endometrial Clear Cell Adenocarcinoma missense_variant 8.333% (1/12) 1 entry
ENSG00000215301 DDX3X oral squamous cell carcinoma sequence_alteration 0.4854% (1/206) 1 entry
ENSG00000215301 DDX3X T-cell acute lymphoblastic leukemia frameshift_variant 1.312% (5/381) 1 entry
ENSG00000215301 DDX3X pharyngeal squamous cell carcinoma stop_gained 6.452% (2/31) 1 entry
ENSG00000215301 DDX3X lung adenocarcinoma stop_gained 1.376% (16/1163) 1 entry
ENSG00000215301 DDX3X melanoma frameshift_variant 2.941% (3/102) 1 entry
ENSG00000215301 DDX3X bile duct adenocarcinoma sequence_alteration 0.5291% (1/189) 1 entry
ENSG00000215301 DDX3X basal cell carcinoma missense_variant 1.724% (1/58) 1 entry
ENSG00000215301 DDX3X clear cell renal carcinoma stop_gained 0.3098% (4/1291) 1 entry
ENSG00000215301 DDX3X melanoma sequence_alteration 2.941% (3/102) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000215301 DDX3X SARC 0.019 high
ENSG00000215301 DDX3X PAAD 0.026 high
ENSG00000215301 DDX3X UCEC 0.025 high
ENSG00000215301 DDX3X LGG 0.00026 high
ENSG00000215301 DDX3X KIRP 0.045 high
ENSG00000215301 DDX3X KICH 0.0028 high
ENSG00000215301 DDX3X PCPG 0.049 low
ENSG00000215301 DDX3X BRCA 0.022 high
ENSG00000215301 DDX3X COAD 0.0033 low
ENSG00000215301 DDX3X ESCA 0.029 high
ENSG00000215301 DDX3X KIRC 0.00037 low
ENSG00000215301 DDX3X PRAD 0.0065 high
ENSG00000215301 DDX3X BLCA 0.029 high
ENSG00000215301 DDX3X LAML 0.024 low
ENSG00000215301 DDX3X GBM 0.033 low
ENSG00000215301 DDX3X SKCM 0.014 low
ENSG00000215301 DDX3X LIHC 0.00018 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency