Ensembl ID ENSG00000214944 Gene ID 64283 Accession 30322
Gene Symbol ARHGEF28 Alias RIP2;RGNEF;p190RHOGEF Full Name Rho guanine nucleotide exchange factor 28
Position 5 : 73626158 - 73941993 Length 315836 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Non-canonical_RBPs
Summary This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

ENSG00000214944 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000214944 ARHGEF28 -1.1 7.25e-40 BRCA
ENSG00000214944 ARHGEF28 -1.1 5.02e-16 PRAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000214944 ARHGEF28 familial breast cancer 16234258
ENSG00000214944 ARHGEF28 cancer 16322093
ENSG00000214944 ARHGEF28 lung cancer 16691626
ENSG00000214944 ARHGEF28 tumor 17704816
ENSG00000214944 ARHGEF28 cancer 19515453
ENSG00000214944 ARHGEF28 breast cancers 19734946
ENSG00000214944 ARHGEF28 tumor 21224360
ENSG00000214944 ARHGEF28 tumor 21356346
ENSG00000214944 ARHGEF28 breast cancer 22002306
ENSG00000214944 ARHGEF28 tumor 22648798
ENSG00000214944 ARHGEF28 cancer 22962269
ENSG00000214944 ARHGEF28 cancer 24126053
ENSG00000214944 ARHGEF28 tumor 24467206
ENSG00000214944 ARHGEF28 breast cancer 25743165
ENSG00000214944 ARHGEF28 tumor 25922072
ENSG00000214944 ARHGEF28 cancers 26112412
ENSG00000214944 ARHGEF28 cancer 26483157
ENSG00000214944 ARHGEF28 cancer 27150042
ENSG00000214944 ARHGEF28 tumor 27617642
ENSG00000214944 ARHGEF28 tumor 27638873
ENSG00000214944 ARHGEF28 ovarian cancer 27690729
ENSG00000214944 ARHGEF28 breast cancer 29233866
ENSG00000214944 ARHGEF28 benign tumors 30001383
ENSG00000214944 ARHGEF28 cancer 30482479
ENSG00000214944 ARHGEF28 ovarian cancer 31308489
ENSG00000214944 ARHGEF28 tumor 31477830
ENSG00000214944 ARHGEF28 tumors 31620201
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000214944 ARHGEF28 MESO 0.026 low
ENSG00000214944 ARHGEF28 SARC 0.0033 low
ENSG00000214944 ARHGEF28 CHOL 0.05 low
ENSG00000214944 ARHGEF28 THCA 0.0027 high
ENSG00000214944 ARHGEF28 ACC 0.0027 low
ENSG00000214944 ARHGEF28 LGG 0.0042 high
ENSG00000214944 ARHGEF28 HNSC 0.05 low
ENSG00000214944 ARHGEF28 READ 0.0015 low
ENSG00000214944 ARHGEF28 KIRP 0.0096 high
ENSG00000214944 ARHGEF28 PCPG 0.022 low
ENSG00000214944 ARHGEF28 THYM 7e-04 high
ENSG00000214944 ARHGEF28 BRCA 0.042 low
ENSG00000214944 ARHGEF28 ESCA 0.047 low
ENSG00000214944 ARHGEF28 PRAD 0.039 low
ENSG00000214944 ARHGEF28 TGCT 0.014 low
ENSG00000214944 ARHGEF28 BLCA 0.0056 low
ENSG00000214944 ARHGEF28 GBM 0.0045 high
ENSG00000214944 ARHGEF28 SKCM 0.029 low
ENSG00000214944 ARHGEF28 CESC 0.00087 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000214944 ARHGEF28 LUSC Del 2.654185 0.090545 0.404775 0.774451
ENSG00000214944 ARHGEF28 LUAD Del 1.834103 0.065463 0.335928 0.391473
ENSG00000214944 ARHGEF28 COAD Del 2.233555 0.058574 0.384919 0.241685
ENSG00000214944 ARHGEF28 UCS Del 1.838870 0.297729 0.487301 0.517857
ENSG00000214944 ARHGEF28 PAAD Del 1.814379 0.067666 0.347030 0.173913
ENSG00000214944 ARHGEF28 ESCA Del 1.968708 0.132389 0.443338 0.592391
ENSG00000214944 ARHGEF28 HNSC Del 1.703930 0.065540 0.385516 0.417625
ENSG00000214944 ARHGEF28 BLCA Del 2.906650 0.110653 0.406311 0.504902
ENSG00000214944 ARHGEF28 BRCA Del 5.414831 0.094732 0.451992 0.269444
ENSG00000214944 ARHGEF28 STAD Del 5.115572 0.109492 0.391542 0.367347
ENSG00000214944 ARHGEF28 PRAD Del 14.283010 0.174060 0.548429 0.184959
ENSG00000214944 ARHGEF28 UCEC Del 6.879690 0.101235 0.520689 0.200371
ENSG00000214944 ARHGEF28 OV Del 73.493714 0.679695 0.676616 0.723661