Ensembl ID ENSG00000214517 Gene ID 51400 Accession 30178
Gene Symbol PPME1 Alias PME-1;ABDH19 Full Name protein phosphatase methylesterase 1
Position 11 : 74171289 - 74254703 Length 83415 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

ENSG00000214517 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000214517 0.71 3.53e-27 BRCA
ENSG00000214517 0.50 1.60e-18 COAD
ENSG00000214517 1.23 3.09e-43 LUSC
ENSG00000214517 -1.0 6.08e-12 GBM
ENSG00000214517 0.44 2.21e-13 LIHC
ENSG00000214517 0.77 4.83e-19 UCEC
ENSG00000214517 0.81 7.19e-32 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000214517 cancer 19293187
ENSG00000214517 cancer 21398589
ENSG00000214517 cancer 21639134
ENSG00000214517 tumor 24059230
ENSG00000214517 lung cancer 24253382
ENSG00000214517 endometrial cancer 24928782
ENSG00000214517 tumor 25653542
ENSG00000214517 rectal cancer 26377365
ENSG00000214517 cancer 26499835
ENSG00000214517 endometrial cancer 27048286
ENSG00000214517 tumor 27150024
ENSG00000214517 tumor 27913678
ENSG00000214517 tumour 30104481
ENSG00000214517 cancer 31214504
ENSG00000214517 AML 31717978
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000214517 MESO 0.0047 high
ENSG00000214517 CHOL 0.036 high
ENSG00000214517 THCA 0.0044 low
ENSG00000214517 ACC 0.00077 high
ENSG00000214517 LUSC 0.03 low
ENSG00000214517 HNSC 0.0046 high
ENSG00000214517 LUAD 0.0075 high
ENSG00000214517 THYM 8e-04 high
ENSG00000214517 BRCA 0.038 high
ENSG00000214517 PRAD 0.031 low
ENSG00000214517 BLCA 0.00076 high
ENSG00000214517 CESC 0.02 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000214517 LUSC Amp 0.707560 0.193710 0.509102 0.259481
ENSG00000214517 LUAD Amp 1.741428 0.143577 0.448514 0.306202
ENSG00000214517 ESCA Amp 5.480421 0.495618 0.807418 0.320652
ENSG00000214517 SKCM Amp 6.835202 0.287378 0.885171 0.166213
ENSG00000214517 HNSC Amp 10.789055 0.288493 0.694842 0.241379
ENSG00000214517 BLCA Amp 1.777559 0.202548 0.581274 0.215686
ENSG00000214517 BRCA Amp 20.700491 0.354795 0.809520 0.224074
ENSG00000214517 BRCA Del 0.610975 0.062252 0.452605 0.229630
ENSG00000214517 STAD Amp 1.154197 0.145910 0.520507 0.219955
ENSG00000214517 OV Amp 6.748837 0.486851 0.715705 0.398964