Ensembl ID ENSG00000214026 Gene ID 6150 Accession 10322
Gene Symbol MRPL23 Alias RPL23;uL23m;L23MRP;RPL23L Full Name mitochondrial ribosomal protein L23
Position 11 : 1947278 - 1984522 Length 37245 bases Strand Plus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11. [provided by RefSeq, Jul 2008]

ENSG00000214026 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000214026 MRPL23 0.77 1.57e-14 KIRC
ENSG00000214026 MRPL23 0.87 4.30e-24 BRCA
ENSG00000214026 MRPL23 1.15 5.43e-13 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000214026 MRPL23 ovarian cancer 19304784
ENSG00000214026 MRPL23 GBM 26781422
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000214026 MRPL23 MESO 0.027 low
ENSG00000214026 MRPL23 SARC 0.044 low
ENSG00000214026 MRPL23 UVM 0.0069 high
ENSG00000214026 MRPL23 UCEC 3e-04 low
ENSG00000214026 MRPL23 THCA 0.0056 low
ENSG00000214026 MRPL23 ACC 0.013 high
ENSG00000214026 MRPL23 KICH 0.019 high
ENSG00000214026 MRPL23 BRCA 0.034 low
ENSG00000214026 MRPL23 COAD 0.036 high
ENSG00000214026 MRPL23 ESCA 0.018 high
ENSG00000214026 MRPL23 OV 0.034 low
ENSG00000214026 MRPL23 KIRC 0.00095 high
ENSG00000214026 MRPL23 PRAD 0.0027 high
ENSG00000214026 MRPL23 BLCA 0.031 low
ENSG00000214026 MRPL23 LAML 0.0055 high
ENSG00000214026 MRPL23 GBM 0.0095 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000214026 MRPL23 LUSC Del 12.173503 0.164018 0.374064 0.487026
ENSG00000214026 MRPL23 LUAD Del 2.507256 0.072386 0.304137 0.271318
ENSG00000214026 MRPL23 LGG Del 9.758928 0.102989 0.572154 0.198830
ENSG00000214026 MRPL23 CESC Del 0.876790 0.070831 0.479656 0.355932
ENSG00000214026 MRPL23 ACC Del 0.755928 0.102250 0.543710 0.288889
ENSG00000214026 MRPL23 SARC Del 1.691118 0.149970 0.511865 0.404669
ENSG00000214026 MRPL23 GBM Del 1.619457 0.063233 0.467776 0.221837
ENSG00000214026 MRPL23 PAAD Del 1.077410 0.053544 0.329765 0.157609
ENSG00000214026 MRPL23 ESCA Del 2.320863 0.141215 0.371519 0.418478
ENSG00000214026 MRPL23 HNSC Del 2.229496 0.070517 0.367210 0.310345
ENSG00000214026 MRPL23 PCPG Del 1.124442 0.067499 0.625468 0.351852
ENSG00000214026 MRPL23 BLCA Del 3.499595 0.117552 0.432117 0.524510
ENSG00000214026 MRPL23 BRCA Del 13.716119 0.128314 0.437515 0.283333
ENSG00000214026 MRPL23 STAD Del 0.731907 0.060884 0.349530 0.206349
ENSG00000214026 MRPL23 UCEC Del 4.641935 0.085969 0.534909 0.192950
ENSG00000214026 MRPL23 OV Del 36.457069 0.489530 0.608276 0.583765