Ensembl ID ENSG00000211460 Gene ID 7247 Accession 12379
Gene Symbol TSN Alias C3PO;RCHF1;TBRBP;TRSLN;BCLF-1;REHF-1 Full Name translin
Position 2 : 121737103 - 121767853 Length 30751 bases Strand Plus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

ENSG00000211460 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000211460 TSN 0.65 1.42e-20 LUSC
ENSG00000211460 TSN 0.61 1.85e-13 STAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000211460 TSN tumor 10640740
ENSG00000211460 TSN AML 11698483
ENSG00000211460 TSN colon cancer 12011998
ENSG00000211460 TSN tumors 12631593
ENSG00000211460 TSN AML 15557167
ENSG00000211460 TSN cancer 17363132
ENSG00000211460 TSN tumor 17945351
ENSG00000211460 TSN cancers 18062930
ENSG00000211460 TSN tumors 19451266
ENSG00000211460 TSN tumour 20380652
ENSG00000211460 TSN tumor 20664959
ENSG00000211460 TSN tumour 21826665
ENSG00000211460 TSN cancer 22123175
ENSG00000211460 TSN cancer 22966958
ENSG00000211460 TSN cancer 23300702
ENSG00000211460 TSN breast cancer 23591394
ENSG00000211460 TSN tumor 23679827
ENSG00000211460 TSN tumor 24194900
ENSG00000211460 TSN tumor 24626595
ENSG00000211460 TSN colon cancer 25350763
ENSG00000211460 TSN tumor 25940438
ENSG00000211460 TSN tumor 26398368
ENSG00000211460 TSN cancers 26808625
ENSG00000211460 TSN gastric cancer 26840565
ENSG00000211460 TSN tumour 27183912
ENSG00000211460 TSN cancer 27612014
ENSG00000211460 TSN cancer 27676663
ENSG00000211460 TSN tumor 27869737
ENSG00000211460 TSN tumors 28209994
ENSG00000211460 TSN tumor 28401257
ENSG00000211460 TSN tumor 28783167
ENSG00000211460 TSN pancreatic cancer 28870807
ENSG00000211460 TSN tumour 28949956
ENSG00000211460 TSN tumors 29048657
ENSG00000211460 TSN cancer 29545541
ENSG00000211460 TSN breast cancer 29574068
ENSG00000211460 TSN cancer 29629572
ENSG00000211460 TSN lung cancer 29952428
ENSG00000211460 TSN tumor 30213025
ENSG00000211460 TSN gastric cancer 30245130
ENSG00000211460 TSN cancer 30945018
ENSG00000211460 TSN colorectal cancer 31607903
ENSG00000211460 TSN tumours 9294613
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000211460 TSN MESO 0.0013 high
ENSG00000211460 TSN SARC 0.024 high
ENSG00000211460 TSN UVM 0.045 low
ENSG00000211460 TSN UCEC 0.00068 high
ENSG00000211460 TSN THCA 0.049 low
ENSG00000211460 TSN ACC 0.00022 high
ENSG00000211460 TSN LGG 0.0095 high
ENSG00000211460 TSN LUSC 0.011 low
ENSG00000211460 TSN HNSC 0.025 high
ENSG00000211460 TSN READ 0.013 high
ENSG00000211460 TSN KICH 0.029 high
ENSG00000211460 TSN LUAD 0.0083 high
ENSG00000211460 TSN PCPG 0.012 high
ENSG00000211460 TSN THYM 0.034 low
ENSG00000211460 TSN BRCA 0.027 high
ENSG00000211460 TSN UCS 0.037 high
ENSG00000211460 TSN PRAD 0.012 low
ENSG00000211460 TSN TGCT 0.0046 low
ENSG00000211460 TSN GBM 0.0034 low
ENSG00000211460 TSN LIHC 0.00017 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000211460 TSN ESCA Amp 1.366624 0.302450 0.601722 0.320652
ENSG00000211460 TSN PRAD Del 6.208366 0.124109 0.505378 0.134146