Ensembl ID
ENSG00000211456
Gene ID
22908
Accession
17059
Gene Symbol
SACM1L
Alias
SAC1
Full Name
SAC1 like phosphatidylinositide phosphatase
Position
3 : 45689186 - 45745412
Length
56227 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs N.A. RBP type
Non-canonical_RBPs
Summary
This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame, downstream translation termination codon via a stop codon readthrough mechanism.[provided by RefSeq, Dec 2017]
ENSG00000211456 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000211456
SACM1L
-0.8
7.71e-21
KIRC
ENSG00000211456
SACM1L
-0.5
9.39e-21
HNSC
ENSG00000211456
SACM1L
1.32
1.34e-17
KICH
ENSG00000211456
SACM1L
-1.0
1.40e-72
LUSC
ENSG00000211456
SACM1L
-0.7
6.18e-30
LUAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000211456
SACM1L
tumours
28486536
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000211456
SACM1L
SARC
0.031
high
show
ENSG00000211456
SACM1L
PAAD
0.015
low
show
ENSG00000211456
SACM1L
THCA
0.025
high
show
ENSG00000211456
SACM1L
ACC
0.042
low
show
ENSG00000211456
SACM1L
READ
0.013
low
show
ENSG00000211456
SACM1L
KIRP
0.036
low
show
ENSG00000211456
SACM1L
KICH
0.018
high
show
ENSG00000211456
SACM1L
LUAD
0.003
low
show
ENSG00000211456
SACM1L
THYM
0.0015
low
show
ENSG00000211456
SACM1L
COAD
0.0095
high
show
ENSG00000211456
SACM1L
OV
0.018
low
show
ENSG00000211456
SACM1L
KIRC
0.0022
low
show
ENSG00000211456
SACM1L
PRAD
0.0029
high
show
ENSG00000211456
SACM1L
BLCA
0.03
low
show
ENSG00000211456
SACM1L
LAML
0.00043
low
show
ENSG00000211456
SACM1L
GBM
0.016
low
show
ENSG00000211456
SACM1L
SKCM
0.00059
low
show
ENSG00000211456
SACM1L
LIHC
0.0029
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000211456
SACM1L
CHOL
Del
1.083918
0.240589
0.628918
0.833333
ENSG00000211456
SACM1L
LUSC
Del
2.161905
0.084926
0.408193
0.858283
ENSG00000211456
SACM1L
LUAD
Del
0.950584
0.054762
0.321973
0.476744
ENSG00000211456
SACM1L
LGG
Del
1.127932
0.043686
0.500852
0.091618
ENSG00000211456
SACM1L
BLCA
Del
1.305010
0.087567
0.380600
0.245098
ENSG00000211456
SACM1L
BRCA
Del
19.587810
0.147361
0.451647
0.301852
ENSG00000211456
SACM1L
STAD
Del
3.097573
0.090835
0.333160
0.324263
ENSG00000211456
SACM1L
UCEC
Del
0.684390
0.047404
0.491793
0.128015
ENSG00000211456
SACM1L
MESO
Del
14.464280
0.487815
0.570865
0.459770
ENSG00000211456
SACM1L
KIRC
Del
51.886395
0.183722
0.516661
0.882576
ENSG00000211456
SACM1L
OV
Del
0.740515
0.175019
0.473001
0.326425
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