Ensembl ID ENSG00000211456 Gene ID 22908 Accession 17059
Gene Symbol SACM1L Alias SAC1 Full Name SAC1 like phosphatidylinositide phosphatase
Position 3 : 45689186 - 45745412 Length 56227 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame, downstream translation termination codon via a stop codon readthrough mechanism.[provided by RefSeq, Dec 2017]

ENSG00000211456 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000211456 SACM1L -0.8 7.71e-21 KIRC
ENSG00000211456 SACM1L -0.5 9.39e-21 HNSC
ENSG00000211456 SACM1L 1.32 1.34e-17 KICH
ENSG00000211456 SACM1L -1.0 1.40e-72 LUSC
ENSG00000211456 SACM1L -0.7 6.18e-30 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000211456 SACM1L tumours 28486536
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000211456 SACM1L SARC 0.031 high
ENSG00000211456 SACM1L PAAD 0.015 low
ENSG00000211456 SACM1L THCA 0.025 high
ENSG00000211456 SACM1L ACC 0.042 low
ENSG00000211456 SACM1L READ 0.013 low
ENSG00000211456 SACM1L KIRP 0.036 low
ENSG00000211456 SACM1L KICH 0.018 high
ENSG00000211456 SACM1L LUAD 0.003 low
ENSG00000211456 SACM1L THYM 0.0015 low
ENSG00000211456 SACM1L COAD 0.0095 high
ENSG00000211456 SACM1L OV 0.018 low
ENSG00000211456 SACM1L KIRC 0.0022 low
ENSG00000211456 SACM1L PRAD 0.0029 high
ENSG00000211456 SACM1L BLCA 0.03 low
ENSG00000211456 SACM1L LAML 0.00043 low
ENSG00000211456 SACM1L GBM 0.016 low
ENSG00000211456 SACM1L SKCM 0.00059 low
ENSG00000211456 SACM1L LIHC 0.0029 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000211456 SACM1L CHOL Del 1.083918 0.240589 0.628918 0.833333
ENSG00000211456 SACM1L LUSC Del 2.161905 0.084926 0.408193 0.858283
ENSG00000211456 SACM1L LUAD Del 0.950584 0.054762 0.321973 0.476744
ENSG00000211456 SACM1L LGG Del 1.127932 0.043686 0.500852 0.091618
ENSG00000211456 SACM1L BLCA Del 1.305010 0.087567 0.380600 0.245098
ENSG00000211456 SACM1L BRCA Del 19.587810 0.147361 0.451647 0.301852
ENSG00000211456 SACM1L STAD Del 3.097573 0.090835 0.333160 0.324263
ENSG00000211456 SACM1L UCEC Del 0.684390 0.047404 0.491793 0.128015
ENSG00000211456 SACM1L MESO Del 14.464280 0.487815 0.570865 0.459770
ENSG00000211456 SACM1L KIRC Del 51.886395 0.183722 0.516661 0.882576
ENSG00000211456 SACM1L OV Del 0.740515 0.175019 0.473001 0.326425