Ensembl ID ENSG00000205339 Gene ID 10527 Accession 9852
Gene Symbol IPO7 Alias Imp7;RANBP7 Full Name importin 7
Position 11 : 9384652 - 9448127 Length 63476 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]

ENSG00000205339 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000205339 IPO7 0.72 4.05e-18 COAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000205339 IPO7 ovarian cancer 20174585
ENSG00000205339 IPO7 cancer 22284678
ENSG00000205339 IPO7 cancer 25345917
ENSG00000205339 IPO7 Lung Cancer 28476804
ENSG00000205339 IPO7 cancer 30045750
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000205339 IPO7 MESO 0.00057 high
ENSG00000205339 IPO7 ACC 0.0019 high
ENSG00000205339 IPO7 LGG 0.0036 low
ENSG00000205339 IPO7 LUSC 0.039 high
ENSG00000205339 IPO7 HNSC 0.012 high
ENSG00000205339 IPO7 READ 0.0053 low
ENSG00000205339 IPO7 KIRP 0.0017 high
ENSG00000205339 IPO7 KICH 0.0038 high
ENSG00000205339 IPO7 LUAD 0.027 high
ENSG00000205339 IPO7 PCPG 0.0074 high
ENSG00000205339 IPO7 OV 0.034 low
ENSG00000205339 IPO7 PRAD 0.026 high
ENSG00000205339 IPO7 BLCA 0.0048 high
ENSG00000205339 IPO7 LAML 0.049 low
ENSG00000205339 IPO7 SKCM 0.0039 low
ENSG00000205339 IPO7 CESC 0.00042 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000205339 IPO7 LUSC Del 9.234694 0.145218 0.365075 0.459082
ENSG00000205339 IPO7 LUAD Del 0.933500 0.054552 0.299389 0.253876
ENSG00000205339 IPO7 LGG Del 5.898069 0.080829 0.574089 0.183236
ENSG00000205339 IPO7 SARC Del 1.154118 0.135226 0.507344 0.381323
ENSG00000205339 IPO7 HNSC Del 1.238095 0.060769 0.357272 0.296935
ENSG00000205339 IPO7 PCPG Del 1.684486 0.078860 0.627174 0.358025
ENSG00000205339 IPO7 BLCA Del 2.054212 0.099243 0.428332 0.531863
ENSG00000205339 IPO7 BRCA Del 7.889065 0.106160 0.426511 0.273148
ENSG00000205339 IPO7 UCEC Del 2.392254 0.067088 0.515570 0.185529
ENSG00000205339 IPO7 OV Del 22.906823 0.402581 0.597007 0.563040