Ensembl ID ENSG00000198890 Gene ID 55170 Accession 18241
Gene Symbol PRMT6 Alias HRMT1L6 Full Name protein arginine methyltransferase 6
Position 1 : 107056674 - 107067636 Length 10963 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]

ENSG00000198890 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000198890 PRMT6 -1.2 4.13e-95 KIRC
ENSG00000198890 PRMT6 -1.3 1.79e-15 KICH
ENSG00000198890 PRMT6 0.76 1.35e-12 LUSC
ENSG00000198890 PRMT6 -0.9 2.04e-19 KIRP
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000198890 PRMT6 tumor 19509293
ENSG00000198890 PRMT6 cancer 19726520
ENSG00000198890 PRMT6 breast cancer 20047962
ENSG00000198890 PRMT6 cancers 20473859
ENSG00000198890 PRMT6 cancer 21619671
ENSG00000198890 PRMT6 breast cancer 22673335
ENSG00000198890 PRMT6 tumor 22904064
ENSG00000198890 PRMT6 tumor 22904088
ENSG00000198890 PRMT6 tumor 22916108
ENSG00000198890 PRMT6 tumour 22987071
ENSG00000198890 PRMT6 lung cancer 23202904
ENSG00000198890 PRMT6 prostate cancer 23380452
ENSG00000198890 PRMT6 lung tumor 23800116
ENSG00000198890 PRMT6 cancer 24447537
ENSG00000198890 PRMT6 breast cancer 24742914
ENSG00000198890 PRMT6 cancer 26094878
ENSG00000198890 PRMT6 cancer 26101569
ENSG00000198890 PRMT6 cancer 26436589
ENSG00000198890 PRMT6 prostate cancer 27323813
ENSG00000198890 PRMT6 cancer 27480107
ENSG00000198890 PRMT6 breast cancer 27556302
ENSG00000198890 PRMT6 breast cancer 29115463
ENSG00000198890 PRMT6 lung cancer 29138553
ENSG00000198890 PRMT6 Cancer 29262320
ENSG00000198890 PRMT6 cancer 29410016
ENSG00000198890 PRMT6 tumor 29507670
ENSG00000198890 PRMT6 colorectal cancer 29927001
ENSG00000198890 PRMT6 Cancer 30332648
ENSG00000198890 PRMT6 cancers 30352814
ENSG00000198890 PRMT6 gastric cancer 30508037
ENSG00000198890 PRMT6 pancreatic cancer 30577570
ENSG00000198890 PRMT6 tumor 30886105
ENSG00000198890 PRMT6 colon tumors 31154022
ENSG00000198890 PRMT6 tumor 31469916
ENSG00000198890 PRMT6 Lung Tumor 31619507
ENSG00000198890 PRMT6 endometrial cancer 31884111
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000198890 PRMT6 MESO 0.014 low
ENSG00000198890 PRMT6 SARC 0.013 high
ENSG00000198890 PRMT6 STAD 0.016 high
ENSG00000198890 PRMT6 UVM 0.018 low
ENSG00000198890 PRMT6 UCEC 0.00064 high
ENSG00000198890 PRMT6 THCA 0.041 low
ENSG00000198890 PRMT6 LUSC 0.013 high
ENSG00000198890 PRMT6 READ 0.0064 low
ENSG00000198890 PRMT6 KICH 0.016 high
ENSG00000198890 PRMT6 LUAD 0.0015 high
ENSG00000198890 PRMT6 PCPG 0.032 low
ENSG00000198890 PRMT6 THYM 0.0098 low
ENSG00000198890 PRMT6 ESCA 0.037 low
ENSG00000198890 PRMT6 OV 0.031 low
ENSG00000198890 PRMT6 DLBC 0.048 high
ENSG00000198890 PRMT6 KIRC 0.0017 low
ENSG00000198890 PRMT6 BLCA 0.0012 high
ENSG00000198890 PRMT6 SKCM 0.043 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000198890 PRMT6 LUSC Del 6.121433 0.122744 0.378280 0.431138
ENSG00000198890 PRMT6 LUAD Del 11.007058 0.133023 0.349534 0.298450
ENSG00000198890 PRMT6 CESC Del 0.825678 0.069363 0.425819 0.098305
ENSG00000198890 PRMT6 READ Del 0.637830 0.068240 0.389884 0.345455
ENSG00000198890 PRMT6 COAD Del 2.734218 0.062895 0.412678 0.274945
ENSG00000198890 PRMT6 ESCA Del 1.127317 0.108853 0.384900 0.304348
ENSG00000198890 PRMT6 SKCM Del 3.549142 0.106200 0.416847 0.234332
ENSG00000198890 PRMT6 HNSC Del 8.804905 0.115109 0.372109 0.204981
ENSG00000198890 PRMT6 PCPG Del 17.115026 0.262643 0.693879 0.734568
ENSG00000198890 PRMT6 BRCA Del 8.306467 0.107964 0.397301 0.318519
ENSG00000198890 PRMT6 MESO Del 7.623774 0.337239 0.561691 0.367816