Ensembl ID ENSG00000198791 Gene ID 29883 Accession 14101
Gene Symbol CNOT7 Alias CAF1;CAF-1;Caf1a;hCAF-1 Full Name CCR4-NOT transcription complex subunit 7
Position 8 : 17224966 - 17246878 Length 21913 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]

ENSG00000198791 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000198791 CNOT7 -0.3 5.25e-11 PRAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000198791 CNOT7 tumor 10733665
ENSG00000198791 CNOT7 tumor 12845644
ENSG00000198791 CNOT7 breast tumors 15059888
ENSG00000198791 CNOT7 tumor 15120576
ENSG00000198791 CNOT7 tumours 17543081
ENSG00000198791 CNOT7 prostatic cancer 19309489
ENSG00000198791 CNOT7 tumors 20178651
ENSG00000198791 CNOT7 rectal cancer 20646649
ENSG00000198791 CNOT7 tumours 21083601
ENSG00000198791 CNOT7 malignant tumours 21109952
ENSG00000198791 CNOT7 tumours 22882088
ENSG00000198791 CNOT7 cancer 23074380
ENSG00000198791 CNOT7 tumour 23109837
ENSG00000198791 CNOT7 tumor 240033
ENSG00000198791 CNOT7 tumour 24039914
ENSG00000198791 CNOT7 pancreatic cancer 24354864
ENSG00000198791 CNOT7 cancer 24928526
ENSG00000198791 CNOT7 cancer 25191340
ENSG00000198791 CNOT7 cancer 25313826
ENSG00000198791 CNOT7 tumor 25919140
ENSG00000198791 CNOT7 Tumor 26807845
ENSG00000198791 CNOT7 cancer 27872192
ENSG00000198791 CNOT7 cancer 28374866
ENSG00000198791 CNOT7 tumor 28423623
ENSG00000198791 CNOT7 tumor 28518141
ENSG00000198791 CNOT7 breast cancer 28591869
ENSG00000198791 CNOT7 cancer 29201167
ENSG00000198791 CNOT7 tumour 2947760
ENSG00000198791 CNOT7 cancer 30353606
ENSG00000198791 CNOT7 cancer 30631061
ENSG00000198791 CNOT7 cancer 30918060
ENSG00000198791 CNOT7 tumor 31475157
ENSG00000198791 CNOT7 tumours 31627329
ENSG00000198791 CNOT7 tumors 4144984
ENSG00000198791 CNOT7 tumor 6189910
ENSG00000198791 CNOT7 tumor 7306955
ENSG00000198791 CNOT7 tumors 7370972
ENSG00000198791 CNOT7 spindle cell tumor 7643016
ENSG00000198791 CNOT7 breast cancer 7690215
ENSG00000198791 CNOT7 tumor 7822797
ENSG00000198791 CNOT7 tumor 7912706
ENSG00000198791 CNOT7 tumor 8524837
ENSG00000198791 CNOT7 tumor 9200443
ENSG00000198791 CNOT7 tumour 9396823
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000198791 CNOT7 MESO 0.028 high
ENSG00000198791 CNOT7 SARC 0.0013 high
ENSG00000198791 CNOT7 UCEC 0.042 high
ENSG00000198791 CNOT7 ACC 0.04 high
ENSG00000198791 CNOT7 LGG 0.05 high
ENSG00000198791 CNOT7 HNSC 0.04 low
ENSG00000198791 CNOT7 READ 0.023 low
ENSG00000198791 CNOT7 KIRP 0.0018 high
ENSG00000198791 CNOT7 LUAD 0.0051 low
ENSG00000198791 CNOT7 PCPG 0.024 high
ENSG00000198791 CNOT7 THYM 0.0041 low
ENSG00000198791 CNOT7 COAD 6e-04 low
ENSG00000198791 CNOT7 OV 0.0061 low
ENSG00000198791 CNOT7 LAML 0.0072 low
ENSG00000198791 CNOT7 GBM 0.036 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000198791 CNOT7 LUSC Del 2.176844 0.085143 0.445280 0.662675
ENSG00000198791 CNOT7 LUAD Del 1.670628 0.063784 0.452514 0.503876
ENSG00000198791 CNOT7 READ Del 6.752864 0.181098 0.679885 0.606061
ENSG00000198791 CNOT7 COAD Del 9.974226 0.112586 0.676026 0.450111
ENSG00000198791 CNOT7 PAAD Del 0.896125 0.049425 0.400665 0.326087
ENSG00000198791 CNOT7 HNSC Del 1.781898 0.066369 0.421219 0.519157
ENSG00000198791 CNOT7 LIHC Del 3.970644 0.110313 0.711361 0.686486
ENSG00000198791 CNOT7 BLCA Del 5.235643 0.136127 0.518111 0.600490
ENSG00000198791 CNOT7 BRCA Del 14.855524 0.132224 0.588872 0.528704
ENSG00000198791 CNOT7 PRAD Del 10.735355 0.153816 0.567174 0.530488
ENSG00000198791 CNOT7 UCEC Del 4.490950 0.084764 0.671068 0.211503
ENSG00000198791 CNOT7 OV Del 22.527374 0.399963 0.749898 0.696028