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Ensembl ID | ENSG00000198625 | Gene ID | 4194 | Accession | 6974 |
Gene Symbol | MDM4 | Alias | HDMX;MDMX;MRP1;BMFS6 | Full Name | MDM4 regulator of p53 |
Position | 1 : 204516379 - 204558120 | Length | 41742 bases | Strand | Plus strand |
Status | Confidence | Main interacting RNAs | N.A. | RBP type | Canonical_RBPs |
Summary | This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011] |
ENSG00000198625 Expression In 33 Tumors
Ensembl ID | Gene symbol | Log2 Foldchange | Pvaue | Cancer |
---|---|---|---|---|
ENSG00000198625 | 0.94 | 2.04e-21 | KIRC | |
ENSG00000198625 | 0.76 | 5.53e-15 | LIHC |
Ensembl ID | Gene symbol | Cancer types | Pubmed ID |
---|---|---|---|
ENSG00000198625 | tumor | 10075736 | |
ENSG00000198625 | tumors | 10626796 | |
ENSG00000198625 | tumors | 11528400 | |
ENSG00000198625 | tumor | 11953423 | |
ENSG00000198625 | Cancer | 12640683 | |
ENSG00000198625 | tumor | 12761890 | |
ENSG00000198625 | tumor | 12860999 | |
ENSG00000198625 | tumor | 14660608 | |
ENSG00000198625 | tumors | 16319692 | |
ENSG00000198625 | tumor | 16905541 | |
ENSG00000198625 | tumour | 17080083 | |
ENSG00000198625 | Tumor | 17110929 | |
ENSG00000198625 | tumour | 17128209 | |
ENSG00000198625 | tumor | 17251377 | |
ENSG00000198625 | tumors | 17327702 | |
ENSG00000198625 | tumour | 17369843 | |
ENSG00000198625 | tumor | 17437278 | |
ENSG00000198625 | cancers | 17499002 | |
ENSG00000198625 | tumors | 17651783 | |
ENSG00000198625 | tumor | 17704807 | |
ENSG00000198625 | tumor | 17875722 | |
ENSG00000198625 | tumor | 17938582 | |
ENSG00000198625 | tumor | 18172009 | |
ENSG00000198625 | tumor | 18211953 | |
ENSG00000198625 | familial breast cancer | 18279506 | |
ENSG00000198625 | thyroid tumor | 18335186 | |
ENSG00000198625 | tumor | 18356162 | |
ENSG00000198625 | bladder cancers | 18451213 | |
ENSG00000198625 | tumor | 18520179 | |
ENSG00000198625 | tumor | 18785023 | |
ENSG00000198625 | tumor | 18826207 | |
ENSG00000198625 | GBM | 19115005 | |
ENSG00000198625 | tumor | 19255450 | |
ENSG00000198625 | cancer | 19273224 | |
ENSG00000198625 | cancers | 19441944 | |
ENSG00000198625 | tumor | 19497887 | |
ENSG00000198625 | ovarian cancer | 19521340 | |
ENSG00000198625 | tumor | 19721810 | |
ENSG00000198625 | cancer | 19727615 | |
ENSG00000198625 | breast cancer | 19762336 | |
ENSG00000198625 | ovarian cancers | 19887911 | |
ENSG00000198625 | cancers | 19910468 | |
ENSG00000198625 | tumors | 20056466 | |
ENSG00000198625 | tumors | 20080970 | |
ENSG00000198625 | GBM | 20169195 | |
ENSG00000198625 | cancers | 20190571 | |
ENSG00000198625 | cancer | 20226197 | |
ENSG00000198625 | tumours | 20229506 | |
ENSG00000198625 | testicular germ cell tumors | 20372076 | |
ENSG00000198625 | tumor | 20406234 | |
ENSG00000198625 | AML | 20423286 | |
ENSG00000198625 | tumors | 20461752 | |
ENSG00000198625 | tumour | 20515689 | |
ENSG00000198625 | tumor | 20520810 | |
ENSG00000198625 | tumor | 20660730 | |
ENSG00000198625 | cancer | 20666148 | |
ENSG00000198625 | tumors | 20680659 | |
ENSG00000198625 | cancers | 20844677 | |
ENSG00000198625 | tumor | 21075301 | |
ENSG00000198625 | cancers | 21075910 | |
ENSG00000198625 | ovarian cancer | 21084273 | |
ENSG00000198625 | tumour | 21145600 | |
ENSG00000198625 | cancer | 21146529 | |
ENSG00000198625 | cancer | 21151896 | |
ENSG00000198625 | tumor | 21200141 | |
ENSG00000198625 | gastric cancer | 21205074 | |
ENSG00000198625 | cancer | 21295684 | |
ENSG00000198625 | tumors | 21391910 | |
ENSG00000198625 | cancer | 21423613 | |
ENSG00000198625 | colorectal cancer | 21503588 | |
ENSG00000198625 | cancer | 21540763 | |
ENSG00000198625 | tumor | 21541195 | |
ENSG00000198625 | cancer | 21562588 | |
ENSG00000198625 | GBM | 21569311 | |
ENSG00000198625 | tumors | 21674059 | |
ENSG00000198625 | breast cancer | 21750655 | |
ENSG00000198625 | GBM | 21807073 | |
ENSG00000198625 | cancer | 21820342 | |
ENSG00000198625 | cancer | 21823114 | |
ENSG00000198625 | tumors | 21910853 | |
ENSG00000198625 | oral cancer | 22052649 | |
ENSG00000198625 | tumor | 22120712 | |
ENSG00000198625 | tumor | 22180099 | |
ENSG00000198625 | tumor | 22279397 | |
ENSG00000198625 | breast cancers | 22313396 | |
ENSG00000198625 | cancers | 22331558 | |
ENSG00000198625 | tumor | 22336108 | |
ENSG00000198625 | cancer | 22370483 | |
ENSG00000198625 | tumors | 22408446 | |
ENSG00000198625 | breast cancer | 22490292 | |
ENSG00000198625 | tumor | 22500917 | |
ENSG00000198625 | breast cancers | 22654484 | |
ENSG00000198625 | tumors | 22675482 | |
ENSG00000198625 | cancers | 22745160 | |
ENSG00000198625 | tumors | 22825724 | |
ENSG00000198625 | tumours | 22845047 | |
ENSG00000198625 | cancers | 22870278 | |
ENSG00000198625 | tumors | 22916154 | |
ENSG00000198625 | cancers | 22949826 | |
ENSG00000198625 | cancer | 23035244 | |
ENSG00000198625 | tumor | 23071490 | |
ENSG00000198625 | tumor | 23233862 | |
ENSG00000198625 | cancer | 23303139 | |
ENSG00000198625 | breast cancer | 23535733 | |
ENSG00000198625 | breast cancer | 23536562 | |
ENSG00000198625 | breast cancer | 23544013 | |
ENSG00000198625 | cancer | 23565502 | |
ENSG00000198625 | cancer | 23724042 | |
ENSG00000198625 | tumors | 23765217 | |
ENSG00000198625 | breast cancer | 23793604 | |
ENSG00000198625 | tumor | 23861893 | |
ENSG00000198625 | cancer | 23946421 | |
ENSG00000198625 | tumors | 23994448 | |
ENSG00000198625 | tumor | 24018792 | |
ENSG00000198625 | tumors | 24027430 | |
ENSG00000198625 | tumors | 24078862 | |
ENSG00000198625 | cancer | 24124625 | |
ENSG00000198625 | breast cancer | 24126697 | |
ENSG00000198625 | cancers | 24127580 | |
ENSG00000198625 | basal-like breast cancer | 24176171 | |
ENSG00000198625 | tumours | 24253812 | |
ENSG00000198625 | cancer | 24278348 | |
ENSG00000198625 | tumor | 24321497 | |
ENSG00000198625 | TN breast cancer | 24325915 | |
ENSG00000198625 | tumour | 24330579 | |
ENSG00000198625 | tumor | 24336076 | |
ENSG00000198625 | breast cancer | 24359602 | |
ENSG00000198625 | cancers | 24445145 | |
ENSG00000198625 | tumors | 24488925 | |
ENSG00000198625 | tumor | 24498027 | |
ENSG00000198625 | cancers | 24608433 | |
ENSG00000198625 | tumor | 24625390 | |
ENSG00000198625 | tumor | 24648050 | |
ENSG00000198625 | tumors | 24756955 | |
ENSG00000198625 | cancer | 24874471 | |
ENSG00000198625 | cancer | 24931984 | |
ENSG00000198625 | tumor | 24958282 | |
ENSG00000198625 | Bladder Cancer | 25026175 | |
ENSG00000198625 | cancer | 25105592 | |
ENSG00000198625 | tumor | 25113507 | |
ENSG00000198625 | cancer | 25114582 | |
ENSG00000198625 | cancer | 25201201 | |
ENSG00000198625 | tumor | 25203442 | |
ENSG00000198625 | tumors | 25341038 | |
ENSG00000198625 | tumor | 25350876 | |
ENSG00000198625 | cancer | 25372739 | |
ENSG00000198625 | cancer | 25405759 | |
ENSG00000198625 | cancers | 25455730 | |
ENSG00000198625 | tumor | 25465288 | |
ENSG00000198625 | tumor | 25469175 | |
ENSG00000198625 | gastric cancer | 25479941 | |
ENSG00000198625 | tumor | 25547493 | |
ENSG00000198625 | cancer | 25621298 | |
ENSG00000198625 | GBM | 25653168 | |
ENSG00000198625 | prostate cancer | 25670033 | |
ENSG00000198625 | tumor | 25703327 | |
ENSG00000198625 | tumors | 25726527 | |
ENSG00000198625 | tumors | 25814188 | |
ENSG00000198625 | cancer | 25961923 | |
ENSG00000198625 | cancers | 25974965 | |
ENSG00000198625 | breast cancer | 25994018 | |
ENSG00000198625 | Cancer | 26001071 | |
ENSG00000198625 | tumour | 26095524 | |
ENSG00000198625 | cancers | 26119925 | |
ENSG00000198625 | Small Cell Lung Cancer | 26274820 | |
ENSG00000198625 | tumors | 26328271 | |
ENSG00000198625 | tumor | 26328274 | |
ENSG00000198625 | tumor | 26363315 | |
ENSG00000198625 | cancer | 26416355 | |
ENSG00000198625 | GBM | 26428461 | |
ENSG00000198625 | cancer | 26471763 | |
ENSG00000198625 | cancer | 26513747 | |
ENSG00000198625 | tumors | 26567881 | |
ENSG00000198625 | tumor | 26595814 | |
ENSG00000198625 | tumors | 26625772 | |
ENSG00000198625 | tumor | 26646257 | |
ENSG00000198625 | salivary gland cancer | 26661925 | |
ENSG00000198625 | cancers | 26858935 | |
ENSG00000198625 | endometrial cancer | 26867771 | |
ENSG00000198625 | tumor | 26876197 | |
ENSG00000198625 | cancers | 26883108 | |
ENSG00000198625 | cancer | 26891980 | |
ENSG00000198625 | tumors | 26909605 | |
ENSG00000198625 | tumors | 26943571 | |
ENSG00000198625 | colorectal cancer | 26957954 | |
ENSG00000198625 | cancers | 26965628 | |
ENSG00000198625 | Cancer | 27022975 | |
ENSG00000198625 | tumors | 27037420 | |
ENSG00000198625 | cancers | 27145840 | |
ENSG00000198625 | tumors | 27187415 | |
ENSG00000198625 | cancers | 27282385 | |
ENSG00000198625 | cancer | 27287767 | |
ENSG00000198625 | tumors | 27302609 | |
ENSG00000198625 | tumor | 27308591 | |
ENSG00000198625 | tumor | 27308631 | |
ENSG00000198625 | cancers | 27329033 | |
ENSG00000198625 | cancers | 27371671 | |
ENSG00000198625 | tumor | 27375027 | |
ENSG00000198625 | breast cancer | 27432230 | |
ENSG00000198625 | non-small cell lung cancer | 27462918 | |
ENSG00000198625 | tumor | 27609158 | |
ENSG00000198625 | tumor | 27621617 | |
ENSG00000198625 | cancers | 27626496 | |
ENSG00000198625 | cancer | 27646776 | |
ENSG00000198625 | cancer | 27659536 | |
ENSG00000198625 | cancer | 27687591 | |
ENSG00000198625 | tumors | 27694836 | |
ENSG00000198625 | cancer | 27738340 | |
ENSG00000198625 | cancer | 27742919 | |
ENSG00000198625 | tumor | 27748758 | |
ENSG00000198625 | tumors | 27776972 | |
ENSG00000198625 | GBM | 27798635 | |
ENSG00000198625 | Bladder Cancer | 27798881 | |
ENSG00000198625 | tumors | 27897991 | |
ENSG00000198625 | ovarian tumor | 28031409 | |
ENSG00000198625 | tumors | 28032389 | |
ENSG00000198625 | tumor | 28048940 | |
ENSG00000198625 | cancers | 28050229 | |
ENSG00000198625 | tumor | 28056866 | |
ENSG00000198625 | cancer | 28069666 | |
ENSG00000198625 | breast cancer | 28096293 | |
ENSG00000198625 | cancers | 28096294 | |
ENSG00000198625 | breast cancers | 28097652 | |
ENSG00000198625 | pancreatic cancer | 28099906 | |
ENSG00000198625 | gastric cancer | 28099948 | |
ENSG00000198625 | tumor | 28126486 | |
ENSG00000198625 | tumor | 28153049 | |
ENSG00000198625 | Breast Cancer | 28164646 | |
ENSG00000198625 | Cancers | 28230750 | |
ENSG00000198625 | tumor | 28265066 | |
ENSG00000198625 | tumor | 28270148 | |
ENSG00000198625 | cancers | 28296148 | |
ENSG00000198625 | tumor | 28351930 | |
ENSG00000198625 | cancer | 28430625 | |
ENSG00000198625 | tumor | 28460439 | |
ENSG00000198625 | tumor | 28480326 | |
ENSG00000198625 | cancer | 28482147 | |
ENSG00000198625 | Thyroid Cancer | 28547953 | |
ENSG00000198625 | non-small cell lung cancer | 28567715 | |
ENSG00000198625 | GBM | 28654422 | |
ENSG00000198625 | cancer | 28673313 | |
ENSG00000198625 | cancer | 28754146 | |
ENSG00000198625 | tumor | 28774266 | |
ENSG00000198625 | tumors | 28904012 | |
ENSG00000198625 | tumor | 28916339 | |
ENSG00000198625 | cancer | 28925398 | |
ENSG00000198625 | cancers | 28927521 | |
ENSG00000198625 | Cancer | 28939739 | |
ENSG00000198625 | tumor | 29065514 | |
ENSG00000198625 | tumors | 29156829 | |
ENSG00000198625 | Cancer | 29158845 | |
ENSG00000198625 | cancer | 29207086 | |
ENSG00000198625 | breast cancer | 29262616 | |
ENSG00000198625 | Prostate Cancer | 29311926 | |
ENSG00000198625 | AML | 29343974 | |
ENSG00000198625 | cancer | 29348869 | |
ENSG00000198625 | breast cancers | 29372105 | |
ENSG00000198625 | tumor | 29393891 | |
ENSG00000198625 | tumor | 29416795 | |
ENSG00000198625 | lung tumor | 29423041 | |
ENSG00000198625 | colon cancer | 29434862 | |
ENSG00000198625 | Susceptibility to Breast Cancer | 29439926 | |
ENSG00000198625 | prostate cancer | 29464071 | |
ENSG00000198625 | breast cancer | 29552226 | |
ENSG00000198625 | AML | 29571049 | |
ENSG00000198625 | tumor | 29593251 | |
ENSG00000198625 | cancers | 29643228 | |
ENSG00000198625 | breast cancer | 29697201 | |
ENSG00000198625 | tumor | 29713287 | |
ENSG00000198625 | tumors | 29753010 | |
ENSG00000198625 | prostate cancer | 29762656 | |
ENSG00000198625 | tumour | 29796170 | |
ENSG00000198625 | pancreas cancer | 29805525 | |
ENSG00000198625 | AML | 29857559 | |
ENSG00000198625 | tumors | 29866007 | |
ENSG00000198625 | tumor | 29905531 | |
ENSG00000198625 | tumour | 29946150 | |
ENSG00000198625 | tumor | 29963263 | |
ENSG00000198625 | tumor | 30018188 | |
ENSG00000198625 | tumor | 30021196 | |
ENSG00000198625 | Tumors | 30026328 | |
ENSG00000198625 | cancer | 30038284 | |
ENSG00000198625 | cancer | 30045945 | |
ENSG00000198625 | DLBCL | 30158596 | |
ENSG00000198625 | GBMs | 30200436 | |
ENSG00000198625 | tumors | 30216042 | |
ENSG00000198625 | tumour | 30255959 | |
ENSG00000198625 | tumors | 30279357 | |
ENSG00000198625 | cancer | 30320185 | |
ENSG00000198625 | triple-negative breast cancer | 30462562 | |
ENSG00000198625 | cancer | 30488540 | |
ENSG00000198625 | prostate cancer | 30526857 | |
ENSG00000198625 | cancer | 30555549 | |
ENSG00000198625 | Cancer | 30555571 | |
ENSG00000198625 | cancer | 30597480 | |
ENSG00000198625 | tumors | 30598450 | |
ENSG00000198625 | cancers | 30603043 | |
ENSG00000198625 | tumor | 30642351 | |
ENSG00000198625 | breast cancer | 30642840 | |
ENSG00000198625 | cancer | 30672125 | |
ENSG00000198625 | cancer | 30689920 | |
ENSG00000198625 | tumour | 30696074 | |
ENSG00000198625 | Malignant Rhabdoid Tumors | 30755442 | |
ENSG00000198625 | tumor | 30761293 | |
ENSG00000198625 | tumor | 30809370 | |
ENSG00000198625 | AMLs | 30813354 | |
ENSG00000198625 | tumors | 30816522 | |
ENSG00000198625 | cancer | 30822185 | |
ENSG00000198625 | tumor | 30846484 | |
ENSG00000198625 | cancers | 30886745 | |
ENSG00000198625 | tumor | 30906631 | |
ENSG00000198625 | colon cancer | 30921731 | |
ENSG00000198625 | breast cancer | 30956778 | |
ENSG00000198625 | breast cancer | 30988301 | |
ENSG00000198625 | cancer | 31000522 | |
ENSG00000198625 | colon cancer | 31007746 | |
ENSG00000198625 | cancer | 31100649 | |
ENSG00000198625 | Cancer | 31160308 | |
ENSG00000198625 | tumor | 31217907 | |
ENSG00000198625 | renal cancer | 31250570 | |
ENSG00000198625 | tumors | 31310659 | |
ENSG00000198625 | cancer | 31322272 | |
ENSG00000198625 | tumor | 31339548 | |
ENSG00000198625 | breast cancer | 31390185 | |
ENSG00000198625 | tumor | 31410780 | |
ENSG00000198625 | tumor | 31439820 | |
ENSG00000198625 | Tumor | 31462704 | |
ENSG00000198625 | tumor | 31489110 | |
ENSG00000198625 | tumors | 31513313 | |
ENSG00000198625 | tumor | 31547268 | |
ENSG00000198625 | tumor | 31692881 | |
ENSG00000198625 | cancer | 31755361 | |
ENSG00000198625 | Breast Cancer | 31892970 | |
ENSG00000198625 | Cancer | 31911865 | |
ENSG00000198625 | GBM | 31963499 |
Ensembl ID | Gene symbol | Cancer | P-value | Which worse | show |
---|---|---|---|---|---|
ENSG00000198625 | SARC | 0.045 | low | ||
ENSG00000198625 | PAAD | 0.0095 | low | ||
ENSG00000198625 | THCA | 0.0088 | high | ||
ENSG00000198625 | LGG | 3e-04 | high | ||
ENSG00000198625 | HNSC | 0.00089 | low | ||
ENSG00000198625 | LUAD | 0.0052 | low | ||
ENSG00000198625 | PCPG | 0.001 | high | ||
ENSG00000198625 | THYM | 0.00077 | low | ||
ENSG00000198625 | UCS | 0.047 | low | ||
ENSG00000198625 | ESCA | 0.016 | high | ||
ENSG00000198625 | OV | 0.037 | low | ||
ENSG00000198625 | KIRC | 0.00067 | high | ||
ENSG00000198625 | PRAD | 0.0094 | high | ||
ENSG00000198625 | BLCA | 0.00037 | low | ||
ENSG00000198625 | GBM | 0.033 | low |
Ensembl ID | Gene symbol | Cancer | CNV type | -log10(q-value) | G-score | average amplitude | frequency |
---|---|---|---|---|---|---|---|
ENSG00000198625 | LUAD | Amp | 2.661575 | 0.162920 | 0.512768 | 0.718992 | |
ENSG00000198625 | LGG | Amp | 16.179105 | 0.214153 | 1.282296 | 0.085770 | |
ENSG00000198625 | READ | Amp | 0.715534 | 0.123563 | 0.599637 | 0.296970 | |
ENSG00000198625 | SARC | Del | 0.863167 | 0.125958 | 0.432179 | 0.256809 | |
ENSG00000198625 | GBM | Amp | 75.198822 | 0.741521 | 1.313178 | 0.277296 | |
ENSG00000198625 | SKCM | Amp | 5.127938 | 0.245653 | 0.733190 | 0.558583 | |
ENSG00000198625 | LIHC | Amp | 5.361515 | 0.213694 | 0.858349 | 0.729730 | |
ENSG00000198625 | DLBC | Amp | 1.969232 | 0.304799 | 0.569904 | 0.333333 | |
ENSG00000198625 | BRCA | Amp | 15.753234 | 0.315669 | 0.803931 | 0.766667 | |
ENSG00000198625 | UCEC | Amp | 3.579839 | 0.160656 | 0.860646 | 0.430427 | |
ENSG00000198625 | KIRC | Amp | 1.250397 | 0.040501 | 0.516731 | 0.115530 | |
ENSG00000198625 | OV | Amp | 0.971068 | 0.338425 | 0.668996 | 0.511226 |