Ensembl ID ENSG00000198589 Gene ID 987 Accession 1742
Gene Symbol LRBA Alias BGL;LBA;CDC4L;CVID8;LAB300;uc.147 Full Name LPS responsive beige-like anchor protein
Position 4 : 150264435 - 151015727 Length 751293 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

ENSG00000198589 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000198589 -1.2 1.28e-51 KIRC
ENSG00000198589 -0.6 7.29e-11 HNSC
ENSG00000198589 0.59 7.37e-12 BRCA
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000198589 breast cancer 10754487
ENSG00000198589 cancer 11064130
ENSG00000198589 breast tumor 11400111
ENSG00000198589 tumor 11785098
ENSG00000198589 tumours 12865915
ENSG00000198589 cancer 15064745
ENSG00000198589 Tumors 16505417
ENSG00000198589 tumors 17196107
ENSG00000198589 breast tumor 23496902
ENSG00000198589 tumor 23819905
ENSG00000198589 tumor 26180901
ENSG00000198589 cancer 28650955
ENSG00000198589 Cancer 28720148
ENSG00000198589 tumor 28915667
ENSG00000198589 colorectal cancer 29844832
ENSG00000198589 Cancer 30737563
ENSG00000198589 tumor 6087390
ENSG00000198589 tumors 7763051
ENSG00000198589 breast cancer 7913659
ENSG00000198589 tumors 8095853
ENSG00000198589 tumors 8251648
ENSG00000198589 breast-cancer 9178804
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000198589 MESO 0.00088 low
ENSG00000198589 UVM 0.0094 high
ENSG00000198589 PAAD 0.019 high
ENSG00000198589 UCEC 0.0042 low
ENSG00000198589 ACC 0.0076 low
ENSG00000198589 LGG 0.0012 high
ENSG00000198589 LUSC 0.029 high
ENSG00000198589 READ 0.01 low
ENSG00000198589 KIRP 0.0012 low
ENSG00000198589 KICH 0.038 high
ENSG00000198589 LUAD 0.012 low
ENSG00000198589 PCPG 0.006 low
ENSG00000198589 COAD 0.0034 low
ENSG00000198589 UCS 0.0028 low
ENSG00000198589 ESCA 0.044 low
ENSG00000198589 OV 0.041 high
ENSG00000198589 DLBC 0.026 high
ENSG00000198589 PRAD 0.036 high
ENSG00000198589 LAML 0.044 high
ENSG00000198589 SKCM 0.028 high
ENSG00000198589 CESC 0.037 high
ENSG00000198589 LIHC 0.03 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000198589 LUSC Del 5.664279 0.119070 0.385940 0.638723
ENSG00000198589 LUAD Del 0.628469 0.049936 0.282931 0.312016
ENSG00000198589 LGG Del 6.700109 0.085683 0.458661 0.243665
ENSG00000198589 CESC Del 1.583292 0.084043 0.460765 0.366102
ENSG00000198589 HNSC Del 4.051077 0.085451 0.358143 0.344828
ENSG00000198589 LIHC Del 1.267848 0.075200 0.532339 0.413514
ENSG00000198589 BLCA Del 2.943849 0.110919 0.369965 0.389706
ENSG00000198589 STAD Del 2.481349 0.084206 0.325415 0.396825
ENSG00000198589 UCEC Del 2.079676 0.064075 0.464012 0.205937
ENSG00000198589 KIRC Del 1.053382 0.027066 0.328858 0.151515
ENSG00000198589 OV Del 5.712182 0.255236 0.611548 0.659758