Ensembl ID ENSG00000198563 Gene ID 7919 Accession 13917
Gene Symbol DDX39B Alias BAT1;UAP56;D6S81E Full Name DExD-box helicase 39B
Position 6 : 31530219 - 31542448 Length 12230 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011]

ENSG00000198563 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000198563 1.57 2.08e-39 KIRC
ENSG00000198563 0.98 1.07e-15 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000198563 tumor 21329510
ENSG00000198563 prostate cancer 28025139
ENSG00000198563 cancer 30176153
ENSG00000198563 tumor 31681747
ENSG00000198563 cancer 31783195
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000198563 SARC 0.0053 high
ENSG00000198563 PAAD 0.024 low
ENSG00000198563 UCEC 0.0013 high
ENSG00000198563 THCA 0.021 high
ENSG00000198563 ACC 0.035 high
ENSG00000198563 HNSC 0.0071 low
ENSG00000198563 READ 0.00027 low
ENSG00000198563 LUAD 0.0072 low
ENSG00000198563 PCPG 0.015 high
ENSG00000198563 THYM 0.018 low
ENSG00000198563 BRCA 0.041 low
ENSG00000198563 COAD 0.0062 high
ENSG00000198563 DLBC 0.04 high
ENSG00000198563 PRAD 0.019 high
ENSG00000198563 GBM 0.028 low
ENSG00000198563 CESC 0.0096 high
ENSG00000198563 LIHC 0.017 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000198563 DLBC Del 1.473551 0.166909 0.534071 0.125000
ENSG00000198563 UVM Amp 1.976306 0.243776 1.147565 0.537500