Ensembl ID ENSG00000198492 Gene ID 51441 Accession 31675
Gene Symbol YTHDF2 Alias DF2;CAHL;HGRG8;NY-REN-2 Full Name YTH N6-methyladenosine RNA binding protein F2
Position 1 : 28736621 - 28769775 Length 33155 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]

ENSG00000198492 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000198492 YTHDF2 0.44 3.04e-14 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000198492 YTHDF2 pancreatic cancers 29135329
ENSG00000198492 YTHDF2 liver cancer 29171881
ENSG00000198492 YTHDF2 gastric cancer 29382422
ENSG00000198492 YTHDF2 prostate cancer 29423080
ENSG00000198492 YTHDF2 cancer 30039919
ENSG00000198492 YTHDF2 pancreatic cancer 30062093
ENSG00000198492 YTHDF2 tumor 30423408
ENSG00000198492 YTHDF2 tumor 30766746
ENSG00000198492 YTHDF2 cancer 30810537
ENSG00000198492 YTHDF2 breast cancer 30922314
ENSG00000198492 YTHDF2 Cancer 31031138
ENSG00000198492 YTHDF2 AML 31142332
ENSG00000198492 YTHDF2 tumor 31239444
ENSG00000198492 YTHDF2 tumor 31243897
ENSG00000198492 YTHDF2 tumor 31474572
ENSG00000198492 YTHDF2 lung cancer 31504235
ENSG00000198492 YTHDF2 cancers 31653849
ENSG00000198492 YTHDF2 cancer 31720080
ENSG00000198492 YTHDF2 liver cancer 31735169
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000198492 YTHDF2 MESO 0.0089 low
ENSG00000198492 YTHDF2 SARC 0.00018 high
ENSG00000198492 YTHDF2 UVM 0.023 high
ENSG00000198492 YTHDF2 UCEC 0.046 low
ENSG00000198492 YTHDF2 THCA 0.04 high
ENSG00000198492 YTHDF2 ACC 0.0012 high
ENSG00000198492 YTHDF2 READ 0.00017 low
ENSG00000198492 YTHDF2 KICH 0.00026 high
ENSG00000198492 YTHDF2 LUAD 0.0065 low
ENSG00000198492 YTHDF2 THYM 0.038 low
ENSG00000198492 YTHDF2 COAD 0.017 low
ENSG00000198492 YTHDF2 KIRC 4e-04 low
ENSG00000198492 YTHDF2 PRAD 0.0011 high
ENSG00000198492 YTHDF2 BLCA 0.0079 low
ENSG00000198492 YTHDF2 LAML 0.033 low
ENSG00000198492 YTHDF2 SKCM 0.03 low
ENSG00000198492 YTHDF2 CESC 0.013 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000198492 YTHDF2 CHOL Del 19.591890 1.016488 0.689078 0.777778
ENSG00000198492 YTHDF2 LUSC Del 2.295972 0.086655 0.379445 0.423154
ENSG00000198492 YTHDF2 LUAD Del 0.885599 0.053923 0.281691 0.240310
ENSG00000198492 YTHDF2 KIRP Del 5.880231 0.071425 0.593303 0.173611
ENSG00000198492 YTHDF2 READ Del 8.573917 0.209968 0.446148 0.454545
ENSG00000198492 YTHDF2 COAD Del 18.148334 0.157716 0.450613 0.354767
ENSG00000198492 YTHDF2 GBM Del 0.719508 0.052162 0.484232 0.069324
ENSG00000198492 YTHDF2 PAAD Del 2.921608 0.085318 0.351449 0.342391
ENSG00000198492 YTHDF2 ESCA Del 1.377757 0.115914 0.346512 0.369565
ENSG00000198492 YTHDF2 HNSC Del 1.177357 0.059940 0.352440 0.170498
ENSG00000198492 YTHDF2 LIHC Del 15.439142 0.205118 0.535992 0.378378
ENSG00000198492 YTHDF2 PCPG Del 1.785593 0.080865 0.672574 0.623457
ENSG00000198492 YTHDF2 BRCA Del 22.042024 0.154679 0.413465 0.392593
ENSG00000198492 YTHDF2 STAD Del 4.786632 0.106547 0.356611 0.258503
ENSG00000198492 YTHDF2 UCEC Del 9.602834 0.117706 0.512350 0.131725
ENSG00000198492 YTHDF2 MESO Del 1.796419 0.167997 0.558487 0.241379
ENSG00000198492 YTHDF2 KIRC Del 6.538055 0.053107 0.419245 0.179924
ENSG00000198492 YTHDF2 UVM Del 1.063142 0.073079 0.771498 0.312500
ENSG00000198492 YTHDF2 OV Del 19.909576 0.381452 0.556103 0.383420