Ensembl ID ENSG00000197894 Gene ID 128 Accession 253
Gene Symbol ADH5 Alias FDH;ADHX;ADH-3;AMEDS;BMFS7;FALDH;GSNOR;GSH-FDH;HEL-S-60p Full Name alcohol dehydrogenase 5 (class III), chi polypeptide
Position 4 : 99070978 - 99088788 Length 17811 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

ENSG00000197894 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000197894 ADH5 -0.6 8.54e-27 KIRC
ENSG00000197894 ADH5 -0.9 8.99e-110 BRCA
ENSG00000197894 ADH5 -0.6 1.25e-12 COAD
ENSG00000197894 ADH5 -0.5 1.09e-11 PRAD
ENSG00000197894 ADH5 -1.9 4.37e-31 CHOL
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000197894 ADH5 pancreatic cancer 18095160
ENSG00000197894 ADH5 tumors 26854735
ENSG00000197894 ADH5 pancreatic tumor 28769575
ENSG00000197894 ADH5 tumor 29552190
ENSG00000197894 ADH5 squamous cell cancer 29808834
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000197894 ADH5 MESO 0.0012 low
ENSG00000197894 ADH5 STAD 0.0019 high
ENSG00000197894 ADH5 PAAD 0.0076 high
ENSG00000197894 ADH5 UCEC 0.00017 low
ENSG00000197894 ADH5 HNSC 0.014 high
ENSG00000197894 ADH5 KIRP 2e-04 low
ENSG00000197894 ADH5 LUAD 0.044 low
ENSG00000197894 ADH5 THYM 0.017 low
ENSG00000197894 ADH5 COAD 0.02 low
ENSG00000197894 ADH5 UCS 0.0068 high
ENSG00000197894 ADH5 ESCA 0.049 low
ENSG00000197894 ADH5 BLCA 0.043 low
ENSG00000197894 ADH5 CESC 0.017 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000197894 ADH5 ESCA Del 0.882966 0.102381 0.401530 0.538043
ENSG00000197894 ADH5 LIHC Del 3.476117 0.104461 0.553704 0.462162
ENSG00000197894 ADH5 OV Del 6.354570 0.262529 0.633450 0.704663