Ensembl ID ENSG00000197694 Gene ID 6709 Accession 11273
Gene Symbol SPTAN1 Alias DEE5;NEAS;EIEE5;SPTA2 Full Name spectrin alpha, non-erythrocytic 1
Position 9 : 128552558 - 128633662 Length 81105 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

ENSG00000197694 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000197694 SPTAN1 -0.5 2.37e-21 KIRC
ENSG00000197694 SPTAN1 -1.1 8.43e-55 LUSC
ENSG00000197694 SPTAN1 -1.7 3.66e-11 GBM
ENSG00000197694 SPTAN1 0.64 2.88e-23 LIHC
ENSG00000197694 SPTAN1 -0.6 4.14e-13 UCEC
ENSG00000197694 SPTAN1 -0.8 4.92e-35 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000197694 SPTAN1 gastric cancer 12127692
ENSG00000197694 SPTAN1 gastric cancer 15025954
ENSG00000197694 SPTAN1 tumors 16773180
ENSG00000197694 SPTAN1 tumors 17280605
ENSG00000197694 SPTAN1 colon cancer 24456667
ENSG00000197694 SPTAN1 GBM 26873924
ENSG00000197694 SPTAN1 lung cancer 28938540
ENSG00000197694 SPTAN1 prostate cancer 29643985
ENSG00000197694 SPTAN1 colorectal cancer 30856214
ENSG00000197694 SPTAN1 tumors 31186638
ENSG00000197694 SPTAN1 lung cancer 31423239
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000197694 SPTAN1 MESO 0.00045 low
ENSG00000197694 SPTAN1 STAD 0.019 low
ENSG00000197694 SPTAN1 CHOL 0.026 low
ENSG00000197694 SPTAN1 THCA 0.0045 low
ENSG00000197694 SPTAN1 LUSC 0.0071 high
ENSG00000197694 SPTAN1 HNSC 0.037 low
ENSG00000197694 SPTAN1 READ 0.0016 low
ENSG00000197694 SPTAN1 LUAD 0.029 low
ENSG00000197694 SPTAN1 PCPG 0.00045 high
ENSG00000197694 SPTAN1 THYM 0.027 high
ENSG00000197694 SPTAN1 BRCA 0.017 low
ENSG00000197694 SPTAN1 ESCA 0.014 high
ENSG00000197694 SPTAN1 OV 0.009 high
ENSG00000197694 SPTAN1 BLCA 0.0017 high
ENSG00000197694 SPTAN1 SKCM 0.038 high
ENSG00000197694 SPTAN1 CESC 0.021 high
ENSG00000197694 SPTAN1 LIHC 0.002 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000197694 SPTAN1 TGCT Del 0.819568 0.058463 0.362198 0.406667
ENSG00000197694 SPTAN1 UCEC Del 1.116313 0.053429 0.536543 0.243043
ENSG00000197694 SPTAN1 OV Del 1.840279 0.199701 0.570854 0.559585