Ensembl ID ENSG00000197345 Gene ID 219927 Accession 14479
Gene Symbol MRPL21 Alias L21mt;bL21m;MRP-L21 Full Name mitochondrial ribosomal protein L21
Position 11 : 68891276 - 68903835 Length 12560 bases Strand Minus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

ENSG00000197345 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000197345 MRPL21 0.73 2.86e-20 BRCA
ENSG00000197345 MRPL21 1.19 1.09e-21 LUSC
ENSG00000197345 MRPL21 0.73 4.45e-14 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000197345 MRPL21 tumor 18973137
ENSG00000197345 MRPL21 tumor 19034969
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000197345 MRPL21 STAD 0.042 low
ENSG00000197345 MRPL21 CHOL 0.012 high
ENSG00000197345 MRPL21 UVM 0.0066 high
ENSG00000197345 MRPL21 UCEC 0.012 high
ENSG00000197345 MRPL21 THCA 0.039 low
ENSG00000197345 MRPL21 ACC 0.0017 high
ENSG00000197345 MRPL21 LGG 0.0052 low
ENSG00000197345 MRPL21 LUSC 0.039 low
ENSG00000197345 MRPL21 HNSC 0.00058 high
ENSG00000197345 MRPL21 READ 0.0052 low
ENSG00000197345 MRPL21 LUAD 0.011 high
ENSG00000197345 MRPL21 BRCA 0.047 low
ENSG00000197345 MRPL21 OV 0.0026 high
ENSG00000197345 MRPL21 LAML 0.0045 high
ENSG00000197345 MRPL21 GBM 0.017 low
ENSG00000197345 MRPL21 SKCM 0.0012 high
ENSG00000197345 MRPL21 CESC 0.032 low
ENSG00000197345 MRPL21 LIHC 0.024 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000197345 MRPL21 CHOL Amp 0.963900 0.494305 1.505423 0.194444
ENSG00000197345 MRPL21 LUSC Amp 19.253906 0.535789 0.868798 0.315369
ENSG00000197345 MRPL21 LUAD Amp 4.072123 0.188328 0.462221 0.331395
ENSG00000197345 MRPL21 CESC Amp 3.463617 0.224662 0.744716 0.132203
ENSG00000197345 MRPL21 ESCA Amp 43.128537 1.595205 1.463345 0.483696
ENSG00000197345 MRPL21 SKCM Amp 8.755062 0.331985 0.940472 0.174387
ENSG00000197345 MRPL21 HNSC Amp 94.692874 1.067884 1.292425 0.371648
ENSG00000197345 MRPL21 LIHC Amp 10.673994 0.298078 1.109798 0.129730
ENSG00000197345 MRPL21 BLCA Amp 10.646353 0.401555 0.722484 0.281863
ENSG00000197345 MRPL21 BRCA Amp 79.530258 0.713569 1.090963 0.301852
ENSG00000197345 MRPL21 STAD Amp 4.195851 0.220776 0.608059 0.235828
ENSG00000197345 MRPL21 PRAD Amp 3.978082 0.091066 0.594138 0.095528
ENSG00000197345 MRPL21 UCEC Amp 1.553393 0.123654 0.618515 0.111317
ENSG00000197345 MRPL21 OV Amp 2.039454 0.375566 0.644062 0.352332