Ensembl ID ENSG00000196961 Gene ID 160 Accession 561
Gene Symbol AP2A1 Alias ADTAA;CLAPA1;AP2-ALPHA Full Name adaptor related protein complex 2 subunit alpha 1
Position 19 : 49767001 - 49807114 Length 40114 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

ENSG00000196961 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000196961 AP2A1 0.38 8.69e-14 KIRC
ENSG00000196961 AP2A1 0.47 6.12e-21 BRCA
ENSG00000196961 AP2A1 -1.4 1.91e-12 GBM
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000196961 AP2A1 tumor 23551967
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000196961 AP2A1 MESO 0.019 high
ENSG00000196961 AP2A1 SARC 0.002 high
ENSG00000196961 AP2A1 STAD 0.027 high
ENSG00000196961 AP2A1 PAAD 0.025 low
ENSG00000196961 AP2A1 LGG 0.0048 high
ENSG00000196961 AP2A1 LUSC 0.0064 high
ENSG00000196961 AP2A1 KIRP 0.0029 high
ENSG00000196961 AP2A1 LUAD 0.0036 high
ENSG00000196961 AP2A1 THYM 0.037 high
ENSG00000196961 AP2A1 BRCA 0.021 high
ENSG00000196961 AP2A1 UCS 0.014 high
ENSG00000196961 AP2A1 ESCA 0.00021 low
ENSG00000196961 AP2A1 OV 3e-04 high
ENSG00000196961 AP2A1 DLBC 0.029 low
ENSG00000196961 AP2A1 BLCA 0.0035 high
ENSG00000196961 AP2A1 LAML 0.00014 high
ENSG00000196961 AP2A1 SKCM 0.00032 high
ENSG00000196961 AP2A1 LIHC 0.013 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000196961 AP2A1 LUSC Del 3.447901 0.098757 0.365840 0.273453
ENSG00000196961 AP2A1 LUAD Del 2.743129 0.074485 0.319289 0.370155
ENSG00000196961 AP2A1 LGG Del 16.877680 0.138866 0.662312 0.506823
ENSG00000196961 AP2A1 CESC Del 0.865705 0.070464 0.427979 0.118644
ENSG00000196961 AP2A1 ACC Amp 0.687386 0.244624 1.016950 0.633333
ENSG00000196961 AP2A1 SARC Del 2.883678 0.176931 0.446573 0.322957
ENSG00000196961 AP2A1 GBM Del 10.943060 0.130969 0.505270 0.168111
ENSG00000196961 AP2A1 PAAD Del 0.704455 0.045307 0.291729 0.114130
ENSG00000196961 AP2A1 UCEC Del 1.225270 0.054836 0.458238 0.113173
ENSG00000196961 AP2A1 OV Del 14.249935 0.337697 0.568707 0.514680