Ensembl ID ENSG00000196924 Gene ID 2316 Accession 3754
Gene Symbol FLNA Alias FLN;FMD;MNS;OPD;ABPX;CSBS;CVD1;FGS2;FLN1;NHBP;OPD1;OPD2;XLVD;XMVD;FLN-A;ABP-280 Full Name filamin A
Position X : 154348524 - 154374634 Length 26111 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

ENSG00000196924 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000196924 FLNA 1.02 5.20e-15 HNSC
ENSG00000196924 FLNA -3.3 1.99e-25 BLCA
ENSG00000196924 FLNA -2.1 1.11e-27 COAD
ENSG00000196924 FLNA -2.5 1.49e-13 READ
ENSG00000196924 FLNA -1.5 8.00e-22 PRAD
ENSG00000196924 FLNA 2.47 5.68e-11 GBM
ENSG00000196924 FLNA -1.9 1.56e-11 STAD
ENSG00000196924 FLNA -2.5 5.59e-43 UCEC
ENSG00000196924 FLNA 2.41 1.39e-14 CHOL
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000196924 FLNA tumor 10545520
ENSG00000196924 FLNA tumor 15530862
ENSG00000196924 FLNA tumor 16291724
ENSG00000196924 FLNA prostate cancer 17420725
ENSG00000196924 FLNA bladder cancer 17606711
ENSG00000196924 FLNA cancer 18598695
ENSG00000196924 FLNA prostate cancer 19188148
ENSG00000196924 FLNA breast cancer 19594548
ENSG00000196924 FLNA pancreatic cancer 19690385
ENSG00000196924 FLNA breast cancer 19808958
ENSG00000196924 FLNA bladder tumors 20139371
ENSG00000196924 FLNA breast cancer 20179208
ENSG00000196924 FLNA tumor 20473907
ENSG00000196924 FLNA cancer 20520840
ENSG00000196924 FLNA cancers 20550479
ENSG00000196924 FLNA cancer 20697352
ENSG00000196924 FLNA breast cancer 20937704
ENSG00000196924 FLNA lung tumors 21036706
ENSG00000196924 FLNA tumors 21267586
ENSG00000196924 FLNA tumour 21421289
ENSG00000196924 FLNA cancer 21503879
ENSG00000196924 FLNA cancer 21533873
ENSG00000196924 FLNA breast cancer 21931851
ENSG00000196924 FLNA cancer 22051193
ENSG00000196924 FLNA tumor 22203038
ENSG00000196924 FLNA tumours 22249249
ENSG00000196924 FLNA tumors 22259062
ENSG00000196924 FLNA cancer 22315094
ENSG00000196924 FLNA tumors 22419889
ENSG00000196924 FLNA breast cancers 22595522
ENSG00000196924 FLNA tumor 22741587
ENSG00000196924 FLNA tumor 22857000
ENSG00000196924 FLNA prostate cancer 22993077
ENSG00000196924 FLNA cancer 23007402
ENSG00000196924 FLNA breast cancer 23289018
ENSG00000196924 FLNA breast cancer 23340249
ENSG00000196924 FLNA cancer 23388158
ENSG00000196924 FLNA tumor 23593504
ENSG00000196924 FLNA GBM 23935471
ENSG00000196924 FLNA cancer 24108109
ENSG00000196924 FLNA breast cancer 24137390
ENSG00000196924 FLNA nasopharyngeal cancer 24218340
ENSG00000196924 FLNA gastric cancer 24241900
ENSG00000196924 FLNA prostate cancer 24390612
ENSG00000196924 FLNA tumor 24550283
ENSG00000196924 FLNA somatotroph tumor 24828612
ENSG00000196924 FLNA tumor 24858105
ENSG00000196924 FLNA tumor 24870795
ENSG00000196924 FLNA tumors 24908328
ENSG00000196924 FLNA cancer 25033545
ENSG00000196924 FLNA pituitary tumors 25068602
ENSG00000196924 FLNA tumor 25084809
ENSG00000196924 FLNA intestinal tumor 25242330
ENSG00000196924 FLNA cancers 25244493
ENSG00000196924 FLNA breast cancer 25454514
ENSG00000196924 FLNA cancer 25481874
ENSG00000196924 FLNA cancer 25609711
ENSG00000196924 FLNA cancer 25717257
ENSG00000196924 FLNA prostate cancer 25759396
ENSG00000196924 FLNA lung cancer 25944616
ENSG00000196924 FLNA tumor 25961669
ENSG00000196924 FLNA cancer 26134617
ENSG00000196924 FLNA Cancers 26341089
ENSG00000196924 FLNA phyllodes tumor 26437033
ENSG00000196924 FLNA ovarian cancer 26446354
ENSG00000196924 FLNA triple-negative breast cancer 26546439
ENSG00000196924 FLNA tumor 26683373
ENSG00000196924 FLNA bladder cancer 26707877
ENSG00000196924 FLNA tumours 26733502
ENSG00000196924 FLNA tumors 26733942
ENSG00000196924 FLNA cancer 26774150
ENSG00000196924 FLNA tumour 27124473
ENSG00000196924 FLNA prostate cancer 27206800
ENSG00000196924 FLNA cervical cancer 27347840
ENSG00000196924 FLNA cancer 27485544
ENSG00000196924 FLNA cancer 27738102
ENSG00000196924 FLNA parathyroid tumors 27872158
ENSG00000196924 FLNA cancer 28031525
ENSG00000196924 FLNA tumour 28187790
ENSG00000196924 FLNA tumor 28231263
ENSG00000196924 FLNA AML 28253492
ENSG00000196924 FLNA prostate cancer 28344825
ENSG00000196924 FLNA cancer 28559546
ENSG00000196924 FLNA Cancer 28697756
ENSG00000196924 FLNA cancer 28721388
ENSG00000196924 FLNA tumours 28727243
ENSG00000196924 FLNA cancer 28778796
ENSG00000196924 FLNA prostate cancer 28855378
ENSG00000196924 FLNA cancer 28881998
ENSG00000196924 FLNA cancer 29023197
ENSG00000196924 FLNA cancer 29052140
ENSG00000196924 FLNA cancer 29065889
ENSG00000196924 FLNA cancer 29100390
ENSG00000196924 FLNA tumors 29288417
ENSG00000196924 FLNA cancer 29596499
ENSG00000196924 FLNA Tumor 29599325
ENSG00000196924 FLNA endometrial cancer 29615978
ENSG00000196924 FLNA Prostate Cancer 29682400
ENSG00000196924 FLNA breast cancer 29720730
ENSG00000196924 FLNA gastric cancer 29862660
ENSG00000196924 FLNA pituitary tumors 29931263
ENSG00000196924 FLNA Breast Cancer 30074213
ENSG00000196924 FLNA pituitary tumor 30098401
ENSG00000196924 FLNA colon cancer 30155352
ENSG00000196924 FLNA tumor 30301907
ENSG00000196924 FLNA breast cancer 30405761
ENSG00000196924 FLNA tumor 30446677
ENSG00000196924 FLNA tumours 30511242
ENSG00000196924 FLNA pituitary tumors 30589642
ENSG00000196924 FLNA tumor 30623593
ENSG00000196924 FLNA tumor 30718563
ENSG00000196924 FLNA tumor 30799513
ENSG00000196924 FLNA GBM 30867563
ENSG00000196924 FLNA tumour 30872976
ENSG00000196924 FLNA colorectal cancer 31002357
ENSG00000196924 FLNA prostate cancer 31013716
ENSG00000196924 FLNA tumor 31268639
ENSG00000196924 FLNA cancer 31358530
ENSG00000196924 FLNA tumor 31384171
ENSG00000196924 FLNA gastric cancer 31452262
ENSG00000196924 FLNA colorectal cancer 31485594
ENSG00000196924 FLNA tumor 31495056
ENSG00000196924 FLNA tumor 31574507
ENSG00000196924 FLNA colorectal cancer 31632499
ENSG00000196924 FLNA phyllodes tumors 31647027
ENSG00000196924 FLNA Ovarian Cancer 31681605
ENSG00000196924 FLNA breast cancer 31747409
ENSG00000196924 FLNA breast cancer 31811830
ENSG00000196924 FLNA cancer 31870551
ENSG00000196924 FLNA tumor 9490735
ENSG00000196924 FLNA Tumor 9921973
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000196924 FLNA chronic myelomonocytic leukemia missense_variant 3.158% (3/95) 1 entry
ENSG00000196924 FLNA small cell lung carcinoma frameshift_variant 4.938% (16/324) 2 entries
ENSG00000196924 FLNA skin melanoma missense_variant 2.689% (26/967) 2 entries
ENSG00000196924 FLNA rectal adenocarcinoma missense_variant 3.084% (7/227) 3 entries
ENSG00000196924 FLNA breast ductal adenocarcinoma missense_variant 2.995% (18/601) 2 entries
ENSG00000196924 FLNA lung adenocarcinoma stop_gained 2.921% (34/1164) 1 entry
ENSG00000196924 FLNA Breast Carcinoma by Gene Expression Profile missense_variant 10.53% (2/19) 2 entries
ENSG00000196924 FLNA small cell lung carcinoma missense_variant 4.938% (16/324) 4 entries
ENSG00000196924 FLNA breast ductal adenocarcinoma sequence_alteration 2.995% (18/601) 2 entries
ENSG00000196924 FLNA skin melanoma stop_gained 2.689% (26/967) 1 entry
ENSG00000196924 FLNA prostate adenocarcinoma sequence_alteration 0.2751% (4/1454) 1 entry
ENSG00000196924 FLNA gastric intestinal type adenocarcinoma missense_variant 4.706% (4/85) 2 entries
ENSG00000196924 FLNA breast phyllodes tumor frameshift_variant 34.88% (30/86) 1 entry
ENSG00000196924 FLNA colorectal adenocarcinoma stop_gained 10.46% (119/1138) 1 entry
ENSG00000196924 FLNA colorectal adenocarcinoma frameshift_variant 10.46% (119/1138) 2 entries
ENSG00000196924 FLNA HER2 Positive Breast Carcinoma missense_variant 4.63% (5/108) 1 entry
ENSG00000196924 FLNA esophageal squamous cell carcinoma missense_variant 2.074% (14/675) 6 entries
ENSG00000196924 FLNA small cell lung carcinoma sequence_alteration 4.938% (16/324) 2 entries
ENSG00000196924 FLNA acute myeloid leukemia sequence_alteration 0.7913% (8/1011) 1 entry
ENSG00000196924 FLNA central nervous system primitive neuroectodermal neoplasm missense_variant 1.802% (8/444) 2 entries
ENSG00000196924 FLNA acute myeloid leukemia missense_variant 0.7913% (8/1011) 1 entry
ENSG00000196924 FLNA clear cell renal carcinoma conservative_inframe_deletion 0.895% (11/1229) 2 entries
ENSG00000196924 FLNA colon adenocarcinoma stop_gained 5.163% (38/736) 1 entry
ENSG00000196924 FLNA hepatocellular carcinoma missense_variant 1.44% (13/903) 1 entry
ENSG00000196924 FLNA breast phyllodes tumor conservative_inframe_deletion 34.88% (30/86) 1 entry
ENSG00000196924 FLNA breast phyllodes tumor missense_variant 34.88% (30/86) 1 entry
ENSG00000196924 FLNA head and neck squamous cell carcinoma missense_variant 0.4792% (3/626) 1 entry
ENSG00000196924 FLNA gastric adenocarcinoma missense_variant 3.405% (19/558) 1 entry
ENSG00000196924 FLNA colon adenocarcinoma frameshift_variant 5.163% (38/736) 2 entries
ENSG00000196924 FLNA female breast carcinoma missense_variant 2.247% (6/267) 1 entry
ENSG00000196924 FLNA basal cell carcinoma sequence_alteration 20.69% (12/58) 1 entry
ENSG00000196924 FLNA esophageal adenocarcinoma missense_variant 0.6849% (3/438) 1 entry
ENSG00000196924 FLNA esophageal squamous cell carcinoma sequence_alteration 2.074% (14/675) 2 entries
ENSG00000196924 FLNA nasopharyngeal squamous cell carcinoma missense_variant 1.198% (2/167) 1 entry
ENSG00000196924 FLNA lung adenocarcinoma missense_variant 2.921% (34/1164) 5 entries
ENSG00000196924 FLNA Merkel cell skin cancer missense_variant 10.0% (3/30) 1 entry
ENSG00000196924 FLNA Cervical Small Cell Carcinoma missense_variant 33.33% (2/6) 1 entry
ENSG00000196924 FLNA melanoma stop_gained 10.89% (11/101) 1 entry
ENSG00000196924 FLNA basal cell carcinoma missense_variant 20.69% (12/58) 1 entry
ENSG00000196924 FLNA colon adenocarcinoma missense_variant 5.163% (38/736) 5 entries
ENSG00000196924 FLNA lung adenocarcinoma sequence_alteration 2.921% (34/1164) 1 entry
ENSG00000196924 FLNA Ampulla of Vater Carcinoma missense_variant 2.353% (2/85) 1 entry
ENSG00000196924 FLNA squamous cell lung carcinoma missense_variant 2.231% (17/762) 1 entry
ENSG00000196924 FLNA oral squamous cell carcinoma missense_variant 2.439% (5/205) 3 entries
ENSG00000196924 FLNA breast carcinoma missense_variant 1.559% (22/1411) 1 entry
ENSG00000196924 FLNA colorectal adenocarcinoma missense_variant 10.46% (119/1138) 4 entries
ENSG00000196924 FLNA female breast carcinoma sequence_alteration 2.247% (6/267) 1 entry
ENSG00000196924 FLNA melanoma missense_variant 10.89% (11/101) 2 entries
ENSG00000196924 FLNA cecum adenocarcinoma missense_variant 8.73% (11/126) 1 entry
ENSG00000196924 FLNA colorectal adenocarcinoma sequence_alteration 10.46% (119/1138) 3 entries
ENSG00000196924 FLNA prostate carcinoma missense_variant 0.7042% (3/426) 1 entry
ENSG00000196924 FLNA diffuse large B-cell lymphoma missense_variant 1.316% (4/304) 2 entries
ENSG00000196924 FLNA skin melanoma sequence_alteration 2.689% (26/967) 1 entry
ENSG00000196924 FLNA colon adenocarcinoma sequence_alteration 5.163% (38/736) 4 entries
ENSG00000196924 FLNA gastric intestinal type adenocarcinoma frameshift_variant 4.706% (4/85) 1 entry
ENSG00000196924 FLNA chronic myelomonocytic leukemia sequence_alteration 3.158% (3/95) 1 entry
ENSG00000196924 FLNA Mixed Lobular and Ductal Breast Carcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000196924 FLNA diffuse large B-cell lymphoma sequence_alteration 1.316% (4/304) 1 entry
ENSG00000196924 FLNA Brain Stem Glioblastoma missense_variant 1.786% (1/56) 1 entry
ENSG00000196924 FLNA rectal adenocarcinoma sequence_alteration 3.084% (7/227) 1 entry
ENSG00000196924 FLNA melanoma sequence_alteration 10.89% (11/101) 1 entry
ENSG00000196924 FLNA chronic myelomonocytic leukemia amino_acid_insertion 3.158% (3/95) 1 entry
ENSG00000196924 FLNA embryonal rhabdomyosarcoma missense_variant 1.316% (1/76) 1 entry
ENSG00000196924 FLNA breast phyllodes tumor amino_acid_insertion 34.88% (30/86) 1 entry
ENSG00000196924 FLNA Gallbladder Adenocarcinoma sequence_alteration 2.299% (2/87) 1 entry
ENSG00000196924 FLNA breast carcinoma stop_gained 1.559% (22/1411) 1 entry
ENSG00000196924 FLNA ovarian mucinous adenocarcinoma sequence_alteration 7.692% (1/13) 1 entry
ENSG00000196924 FLNA colonic neoplasm missense_variant 5.556% (1/18) 1 entry
ENSG00000196924 FLNA colonic neoplasm sequence_alteration 5.556% (1/18) 1 entry
ENSG00000196924 FLNA female breast carcinoma stop_gained 2.247% (6/267) 1 entry
ENSG00000196924 FLNA endometrial carcinoma missense_variant 8.696% (2/23) 1 entry
ENSG00000196924 FLNA large cell lung carcinoma missense_variant 5.556% (1/18) 1 entry
ENSG00000196924 FLNA Pancreatic Acinar Cell Carcinoma missense_variant 5.0% (1/20) 1 entry
ENSG00000196924 FLNA endometrial carcinoma frameshift_variant 8.696% (2/23) 1 entry
ENSG00000196924 FLNA oral squamous cell carcinoma conservative_inframe_deletion 2.439% (5/205) 1 entry
ENSG00000196924 FLNA ovarian mucinous adenocarcinoma missense_variant 7.692% (1/13) 1 entry
ENSG00000196924 FLNA ovarian serous adenocarcinoma missense_variant 0.1486% (1/673) 1 entry
ENSG00000196924 FLNA Fibroadenoma missense_variant 2.941% (1/34) 1 entry
ENSG00000196924 FLNA Ampulla of Vater Carcinoma sequence_alteration 2.353% (2/85) 1 entry
ENSG00000196924 FLNA adrenal cortex carcinoma sequence_alteration 0.6098% (1/164) 1 entry
ENSG00000196924 FLNA basal cell carcinoma frameshift_variant 20.69% (12/58) 1 entry
ENSG00000196924 FLNA kidney Wilms tumor sequence_alteration 0.3145% (1/318) 1 entry
ENSG00000196924 FLNA T-cell acute lymphoblastic leukemia missense_variant 0.1684% (1/594) 1 entry
ENSG00000196924 FLNA primary peritoneal carcinoma (disease) missense_variant 100.0% (1/1) 1 entry
ENSG00000196924 FLNA Invasive Breast Carcinoma missense_variant 2.174% (1/46) 1 entry
ENSG00000196924 FLNA lung carcinoid tumor stop_gained 9.091% (1/11) 1 entry
ENSG00000196924 FLNA head and neck squamous cell carcinoma sequence_alteration 0.4792% (3/626) 1 entry
ENSG00000196924 FLNA oral squamous cell carcinoma stop_gained 2.439% (5/205) 1 entry
ENSG00000196924 FLNA chronic lymphocytic leukemia missense_variant 0.2252% (2/888) 1 entry
ENSG00000196924 FLNA Merkel cell skin cancer sequence_alteration 10.0% (3/30) 1 entry
ENSG00000196924 FLNA osteosarcoma sequence_alteration 1.724% (2/116) 1 entry
ENSG00000196924 FLNA kidney Wilms tumor missense_variant 0.3145% (1/318) 1 entry
ENSG00000196924 FLNA bile duct adenocarcinoma missense_variant 0.5291% (1/189) 1 entry
ENSG00000196924 FLNA mucosal melanoma sequence_alteration 7.143% (1/14) 1 entry
ENSG00000196924 FLNA Gallbladder Adenocarcinoma missense_variant 2.299% (2/87) 1 entry
ENSG00000196924 FLNA acute lymphoblastic leukemia missense_variant 0.3115% (1/321) 1 entry
ENSG00000196924 FLNA laryngeal squamous cell carcinoma sequence_alteration 3.846% (1/26) 1 entry
ENSG00000196924 FLNA Borderline Ovarian Mucinous Tumor missense_variant 12.5% (1/8) 1 entry
ENSG00000196924 FLNA esophageal adenocarcinoma sequence_alteration 0.6849% (3/438) 1 entry
ENSG00000196924 FLNA esophageal squamous cell carcinoma frameshift_variant 2.074% (14/675) 1 entry
ENSG00000196924 FLNA osteosarcoma missense_variant 1.724% (2/116) 1 entry
ENSG00000196924 FLNA embryonal rhabdomyosarcoma sequence_alteration 1.316% (1/76) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000196924 FLNA MESO 0.00077 high
ENSG00000196924 FLNA SARC 0.018 low
ENSG00000196924 FLNA STAD 0.0041 high
ENSG00000196924 FLNA CHOL 0.012 high
ENSG00000196924 FLNA UVM 0.026 high
ENSG00000196924 FLNA PAAD 0.0086 high
ENSG00000196924 FLNA LUSC 0.034 high
ENSG00000196924 FLNA HNSC 0.0063 high
ENSG00000196924 FLNA READ 0.0093 high
ENSG00000196924 FLNA THYM 0.028 high
ENSG00000196924 FLNA COAD 0.0037 high
ENSG00000196924 FLNA ESCA 0.0066 low
ENSG00000196924 FLNA BLCA 0.00034 high
ENSG00000196924 FLNA LAML 0.001 high
ENSG00000196924 FLNA SKCM 0.028 high
ENSG00000196924 FLNA CESC 0.018 high
ENSG00000196924 FLNA LIHC 0.049 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency