Ensembl ID ENSG00000196924 Gene ID 2316 Accession 3754
Gene Symbol FLNA Alias FLN;FMD;MNS;OPD;ABPX;CSBS;CVD1;FGS2;FLN1;NHBP;OPD1;OPD2;XLVD;XMVD;FLN-A;ABP-280 Full Name filamin A
Position X : 154348524 - 154374634 Length 26111 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

ENSG00000196924 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000196924 1.02 5.20e-15 HNSC
ENSG00000196924 -3.3 1.99e-25 BLCA
ENSG00000196924 -2.1 1.11e-27 COAD
ENSG00000196924 -2.5 1.49e-13 READ
ENSG00000196924 -1.5 8.00e-22 PRAD
ENSG00000196924 2.47 5.68e-11 GBM
ENSG00000196924 -1.9 1.56e-11 STAD
ENSG00000196924 -2.5 5.59e-43 UCEC
ENSG00000196924 2.41 1.39e-14 CHOL
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000196924 tumor 10545520
ENSG00000196924 tumor 15530862
ENSG00000196924 tumor 16291724
ENSG00000196924 prostate cancer 17420725
ENSG00000196924 bladder cancer 17606711
ENSG00000196924 cancer 18598695
ENSG00000196924 prostate cancer 19188148
ENSG00000196924 breast cancer 19594548
ENSG00000196924 pancreatic cancer 19690385
ENSG00000196924 breast cancer 19808958
ENSG00000196924 bladder tumors 20139371
ENSG00000196924 breast cancer 20179208
ENSG00000196924 tumor 20473907
ENSG00000196924 cancer 20520840
ENSG00000196924 cancers 20550479
ENSG00000196924 cancer 20697352
ENSG00000196924 breast cancer 20937704
ENSG00000196924 lung tumors 21036706
ENSG00000196924 tumors 21267586
ENSG00000196924 tumour 21421289
ENSG00000196924 cancer 21503879
ENSG00000196924 cancer 21533873
ENSG00000196924 breast cancer 21931851
ENSG00000196924 cancer 22051193
ENSG00000196924 tumor 22203038
ENSG00000196924 tumours 22249249
ENSG00000196924 tumors 22259062
ENSG00000196924 cancer 22315094
ENSG00000196924 tumors 22419889
ENSG00000196924 breast cancers 22595522
ENSG00000196924 tumor 22741587
ENSG00000196924 tumor 22857000
ENSG00000196924 prostate cancer 22993077
ENSG00000196924 cancer 23007402
ENSG00000196924 breast cancer 23289018
ENSG00000196924 breast cancer 23340249
ENSG00000196924 cancer 23388158
ENSG00000196924 tumor 23593504
ENSG00000196924 GBM 23935471
ENSG00000196924 cancer 24108109
ENSG00000196924 breast cancer 24137390
ENSG00000196924 nasopharyngeal cancer 24218340
ENSG00000196924 gastric cancer 24241900
ENSG00000196924 prostate cancer 24390612
ENSG00000196924 tumor 24550283
ENSG00000196924 somatotroph tumor 24828612
ENSG00000196924 tumor 24858105
ENSG00000196924 tumor 24870795
ENSG00000196924 tumors 24908328
ENSG00000196924 cancer 25033545
ENSG00000196924 pituitary tumors 25068602
ENSG00000196924 tumor 25084809
ENSG00000196924 intestinal tumor 25242330
ENSG00000196924 cancers 25244493
ENSG00000196924 breast cancer 25454514
ENSG00000196924 cancer 25481874
ENSG00000196924 cancer 25609711
ENSG00000196924 cancer 25717257
ENSG00000196924 prostate cancer 25759396
ENSG00000196924 lung cancer 25944616
ENSG00000196924 tumor 25961669
ENSG00000196924 cancer 26134617
ENSG00000196924 Cancers 26341089
ENSG00000196924 phyllodes tumor 26437033
ENSG00000196924 ovarian cancer 26446354
ENSG00000196924 triple-negative breast cancer 26546439
ENSG00000196924 tumor 26683373
ENSG00000196924 bladder cancer 26707877
ENSG00000196924 tumours 26733502
ENSG00000196924 tumors 26733942
ENSG00000196924 cancer 26774150
ENSG00000196924 tumour 27124473
ENSG00000196924 prostate cancer 27206800
ENSG00000196924 cervical cancer 27347840
ENSG00000196924 cancer 27485544
ENSG00000196924 cancer 27738102
ENSG00000196924 parathyroid tumors 27872158
ENSG00000196924 cancer 28031525
ENSG00000196924 tumour 28187790
ENSG00000196924 tumor 28231263
ENSG00000196924 AML 28253492
ENSG00000196924 prostate cancer 28344825
ENSG00000196924 cancer 28559546
ENSG00000196924 Cancer 28697756
ENSG00000196924 cancer 28721388
ENSG00000196924 tumours 28727243
ENSG00000196924 cancer 28778796
ENSG00000196924 prostate cancer 28855378
ENSG00000196924 cancer 28881998
ENSG00000196924 cancer 29023197
ENSG00000196924 cancer 29052140
ENSG00000196924 cancer 29065889
ENSG00000196924 cancer 29100390
ENSG00000196924 tumors 29288417
ENSG00000196924 cancer 29596499
ENSG00000196924 Tumor 29599325
ENSG00000196924 endometrial cancer 29615978
ENSG00000196924 Prostate Cancer 29682400
ENSG00000196924 breast cancer 29720730
ENSG00000196924 gastric cancer 29862660
ENSG00000196924 pituitary tumors 29931263
ENSG00000196924 Breast Cancer 30074213
ENSG00000196924 pituitary tumor 30098401
ENSG00000196924 colon cancer 30155352
ENSG00000196924 tumor 30301907
ENSG00000196924 breast cancer 30405761
ENSG00000196924 tumor 30446677
ENSG00000196924 tumours 30511242
ENSG00000196924 pituitary tumors 30589642
ENSG00000196924 tumor 30623593
ENSG00000196924 tumor 30718563
ENSG00000196924 tumor 30799513
ENSG00000196924 GBM 30867563
ENSG00000196924 tumour 30872976
ENSG00000196924 colorectal cancer 31002357
ENSG00000196924 prostate cancer 31013716
ENSG00000196924 tumor 31268639
ENSG00000196924 cancer 31358530
ENSG00000196924 tumor 31384171
ENSG00000196924 gastric cancer 31452262
ENSG00000196924 colorectal cancer 31485594
ENSG00000196924 tumor 31495056
ENSG00000196924 tumor 31574507
ENSG00000196924 colorectal cancer 31632499
ENSG00000196924 phyllodes tumors 31647027
ENSG00000196924 Ovarian Cancer 31681605
ENSG00000196924 breast cancer 31747409
ENSG00000196924 breast cancer 31811830
ENSG00000196924 cancer 31870551
ENSG00000196924 tumor 9490735
ENSG00000196924 Tumor 9921973
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000196924 chronic myelomonocytic leukemia missense_variant 3.158% (3/95) 1 entry
ENSG00000196924 small cell lung carcinoma frameshift_variant 4.938% (16/324) 2 entries
ENSG00000196924 skin melanoma missense_variant 2.689% (26/967) 2 entries
ENSG00000196924 rectal adenocarcinoma missense_variant 3.084% (7/227) 3 entries
ENSG00000196924 breast ductal adenocarcinoma missense_variant 2.995% (18/601) 2 entries
ENSG00000196924 lung adenocarcinoma stop_gained 2.921% (34/1164) 1 entry
ENSG00000196924 Breast Carcinoma by Gene Expression Profile missense_variant 10.53% (2/19) 2 entries
ENSG00000196924 small cell lung carcinoma missense_variant 4.938% (16/324) 4 entries
ENSG00000196924 breast ductal adenocarcinoma sequence_alteration 2.995% (18/601) 2 entries
ENSG00000196924 skin melanoma stop_gained 2.689% (26/967) 1 entry
ENSG00000196924 prostate adenocarcinoma sequence_alteration 0.2751% (4/1454) 1 entry
ENSG00000196924 gastric intestinal type adenocarcinoma missense_variant 4.706% (4/85) 2 entries
ENSG00000196924 breast phyllodes tumor frameshift_variant 34.88% (30/86) 1 entry
ENSG00000196924 colorectal adenocarcinoma stop_gained 10.46% (119/1138) 1 entry
ENSG00000196924 colorectal adenocarcinoma frameshift_variant 10.46% (119/1138) 2 entries
ENSG00000196924 HER2 Positive Breast Carcinoma missense_variant 4.63% (5/108) 1 entry
ENSG00000196924 esophageal squamous cell carcinoma missense_variant 2.074% (14/675) 6 entries
ENSG00000196924 small cell lung carcinoma sequence_alteration 4.938% (16/324) 2 entries
ENSG00000196924 acute myeloid leukemia sequence_alteration 0.7913% (8/1011) 1 entry
ENSG00000196924 central nervous system primitive neuroectodermal neoplasm missense_variant 1.802% (8/444) 2 entries
ENSG00000196924 acute myeloid leukemia missense_variant 0.7913% (8/1011) 1 entry
ENSG00000196924 clear cell renal carcinoma conservative_inframe_deletion 0.895% (11/1229) 2 entries
ENSG00000196924 colon adenocarcinoma stop_gained 5.163% (38/736) 1 entry
ENSG00000196924 hepatocellular carcinoma missense_variant 1.44% (13/903) 1 entry
ENSG00000196924 breast phyllodes tumor conservative_inframe_deletion 34.88% (30/86) 1 entry
ENSG00000196924 breast phyllodes tumor missense_variant 34.88% (30/86) 1 entry
ENSG00000196924 head and neck squamous cell carcinoma missense_variant 0.4792% (3/626) 1 entry
ENSG00000196924 gastric adenocarcinoma missense_variant 3.405% (19/558) 1 entry
ENSG00000196924 colon adenocarcinoma frameshift_variant 5.163% (38/736) 2 entries
ENSG00000196924 female breast carcinoma missense_variant 2.247% (6/267) 1 entry
ENSG00000196924 basal cell carcinoma sequence_alteration 20.69% (12/58) 1 entry
ENSG00000196924 esophageal adenocarcinoma missense_variant 0.6849% (3/438) 1 entry
ENSG00000196924 esophageal squamous cell carcinoma sequence_alteration 2.074% (14/675) 2 entries
ENSG00000196924 nasopharyngeal squamous cell carcinoma missense_variant 1.198% (2/167) 1 entry
ENSG00000196924 lung adenocarcinoma missense_variant 2.921% (34/1164) 5 entries
ENSG00000196924 Merkel cell skin cancer missense_variant 10.0% (3/30) 1 entry
ENSG00000196924 Cervical Small Cell Carcinoma missense_variant 33.33% (2/6) 1 entry
ENSG00000196924 melanoma stop_gained 10.89% (11/101) 1 entry
ENSG00000196924 basal cell carcinoma missense_variant 20.69% (12/58) 1 entry
ENSG00000196924 colon adenocarcinoma missense_variant 5.163% (38/736) 5 entries
ENSG00000196924 lung adenocarcinoma sequence_alteration 2.921% (34/1164) 1 entry
ENSG00000196924 Ampulla of Vater Carcinoma missense_variant 2.353% (2/85) 1 entry
ENSG00000196924 squamous cell lung carcinoma missense_variant 2.231% (17/762) 1 entry
ENSG00000196924 oral squamous cell carcinoma missense_variant 2.439% (5/205) 3 entries
ENSG00000196924 breast carcinoma missense_variant 1.559% (22/1411) 1 entry
ENSG00000196924 colorectal adenocarcinoma missense_variant 10.46% (119/1138) 4 entries
ENSG00000196924 female breast carcinoma sequence_alteration 2.247% (6/267) 1 entry
ENSG00000196924 melanoma missense_variant 10.89% (11/101) 2 entries
ENSG00000196924 cecum adenocarcinoma missense_variant 8.73% (11/126) 1 entry
ENSG00000196924 colorectal adenocarcinoma sequence_alteration 10.46% (119/1138) 3 entries
ENSG00000196924 prostate carcinoma missense_variant 0.7042% (3/426) 1 entry
ENSG00000196924 diffuse large B-cell lymphoma missense_variant 1.316% (4/304) 2 entries
ENSG00000196924 skin melanoma sequence_alteration 2.689% (26/967) 1 entry
ENSG00000196924 colon adenocarcinoma sequence_alteration 5.163% (38/736) 4 entries
ENSG00000196924 gastric intestinal type adenocarcinoma frameshift_variant 4.706% (4/85) 1 entry
ENSG00000196924 chronic myelomonocytic leukemia sequence_alteration 3.158% (3/95) 1 entry
ENSG00000196924 Mixed Lobular and Ductal Breast Carcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000196924 diffuse large B-cell lymphoma sequence_alteration 1.316% (4/304) 1 entry
ENSG00000196924 Brain Stem Glioblastoma missense_variant 1.786% (1/56) 1 entry
ENSG00000196924 rectal adenocarcinoma sequence_alteration 3.084% (7/227) 1 entry
ENSG00000196924 melanoma sequence_alteration 10.89% (11/101) 1 entry
ENSG00000196924 chronic myelomonocytic leukemia amino_acid_insertion 3.158% (3/95) 1 entry
ENSG00000196924 embryonal rhabdomyosarcoma missense_variant 1.316% (1/76) 1 entry
ENSG00000196924 breast phyllodes tumor amino_acid_insertion 34.88% (30/86) 1 entry
ENSG00000196924 Gallbladder Adenocarcinoma sequence_alteration 2.299% (2/87) 1 entry
ENSG00000196924 breast carcinoma stop_gained 1.559% (22/1411) 1 entry
ENSG00000196924 ovarian mucinous adenocarcinoma sequence_alteration 7.692% (1/13) 1 entry
ENSG00000196924 colonic neoplasm missense_variant 5.556% (1/18) 1 entry
ENSG00000196924 colonic neoplasm sequence_alteration 5.556% (1/18) 1 entry
ENSG00000196924 female breast carcinoma stop_gained 2.247% (6/267) 1 entry
ENSG00000196924 endometrial carcinoma missense_variant 8.696% (2/23) 1 entry
ENSG00000196924 large cell lung carcinoma missense_variant 5.556% (1/18) 1 entry
ENSG00000196924 Pancreatic Acinar Cell Carcinoma missense_variant 5.0% (1/20) 1 entry
ENSG00000196924 endometrial carcinoma frameshift_variant 8.696% (2/23) 1 entry
ENSG00000196924 oral squamous cell carcinoma conservative_inframe_deletion 2.439% (5/205) 1 entry
ENSG00000196924 ovarian mucinous adenocarcinoma missense_variant 7.692% (1/13) 1 entry
ENSG00000196924 ovarian serous adenocarcinoma missense_variant 0.1486% (1/673) 1 entry
ENSG00000196924 Fibroadenoma missense_variant 2.941% (1/34) 1 entry
ENSG00000196924 Ampulla of Vater Carcinoma sequence_alteration 2.353% (2/85) 1 entry
ENSG00000196924 adrenal cortex carcinoma sequence_alteration 0.6098% (1/164) 1 entry
ENSG00000196924 basal cell carcinoma frameshift_variant 20.69% (12/58) 1 entry
ENSG00000196924 kidney Wilms tumor sequence_alteration 0.3145% (1/318) 1 entry
ENSG00000196924 T-cell acute lymphoblastic leukemia missense_variant 0.1684% (1/594) 1 entry
ENSG00000196924 primary peritoneal carcinoma (disease) missense_variant 100.0% (1/1) 1 entry
ENSG00000196924 Invasive Breast Carcinoma missense_variant 2.174% (1/46) 1 entry
ENSG00000196924 lung carcinoid tumor stop_gained 9.091% (1/11) 1 entry
ENSG00000196924 head and neck squamous cell carcinoma sequence_alteration 0.4792% (3/626) 1 entry
ENSG00000196924 oral squamous cell carcinoma stop_gained 2.439% (5/205) 1 entry
ENSG00000196924 chronic lymphocytic leukemia missense_variant 0.2252% (2/888) 1 entry
ENSG00000196924 Merkel cell skin cancer sequence_alteration 10.0% (3/30) 1 entry
ENSG00000196924 osteosarcoma sequence_alteration 1.724% (2/116) 1 entry
ENSG00000196924 kidney Wilms tumor missense_variant 0.3145% (1/318) 1 entry
ENSG00000196924 bile duct adenocarcinoma missense_variant 0.5291% (1/189) 1 entry
ENSG00000196924 mucosal melanoma sequence_alteration 7.143% (1/14) 1 entry
ENSG00000196924 Gallbladder Adenocarcinoma missense_variant 2.299% (2/87) 1 entry
ENSG00000196924 acute lymphoblastic leukemia missense_variant 0.3115% (1/321) 1 entry
ENSG00000196924 laryngeal squamous cell carcinoma sequence_alteration 3.846% (1/26) 1 entry
ENSG00000196924 Borderline Ovarian Mucinous Tumor missense_variant 12.5% (1/8) 1 entry
ENSG00000196924 esophageal adenocarcinoma sequence_alteration 0.6849% (3/438) 1 entry
ENSG00000196924 esophageal squamous cell carcinoma frameshift_variant 2.074% (14/675) 1 entry
ENSG00000196924 osteosarcoma missense_variant 1.724% (2/116) 1 entry
ENSG00000196924 embryonal rhabdomyosarcoma sequence_alteration 1.316% (1/76) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000196924 MESO 0.00077 high
ENSG00000196924 SARC 0.018 low
ENSG00000196924 STAD 0.0041 high
ENSG00000196924 CHOL 0.012 high
ENSG00000196924 UVM 0.026 high
ENSG00000196924 PAAD 0.0086 high
ENSG00000196924 LUSC 0.034 high
ENSG00000196924 HNSC 0.0063 high
ENSG00000196924 READ 0.0093 high
ENSG00000196924 THYM 0.028 high
ENSG00000196924 COAD 0.0037 high
ENSG00000196924 ESCA 0.0066 low
ENSG00000196924 BLCA 0.00034 high
ENSG00000196924 LAML 0.001 high
ENSG00000196924 SKCM 0.028 high
ENSG00000196924 CESC 0.018 high
ENSG00000196924 LIHC 0.049 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency